Results 161 to 170 of about 2,936,789 (384)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Pleural fluid C-C class chemokines 22 and pleural effusion due to heart failure: a prospective and double-blind diagnostic accuracy test

BMJ Open Respiratory Research
Background Previous studies have indicated that C-C class chemokine ligand 22 (CCL22) is involved in the pathogenesis of tuberculous pleural effusion and malignant pleural effusion.
Li Yan, Zhi-De Hu, Qianghua Zhou, Wen Zhao, José M Porcel, Su-Na Cha, Yan Niu, Jian-Xun Wen, Cheng Yan, Hong-Zhe Zhu, Ying-Jun Wang, Ling Hai, Ting-Wang Jiang, Wen-Qi Zheng   +13 more
doaj   +1 more source

Mortality Prediction Utilizing Blood Biomarkers to Predict the Severity of COVID-19 Using Machine Learning Technique [PDF]

, 2021
Tawsifur Rahman, Fajer Al‐Ishaq, Fatima S. Al-Mohannadi, Reem Mubarak, Maryam Al-Hitmi, Khandaker Reajul Islam, Amith Khandakar, Ali Ait Hssain, Somaya Al-Máadeed, Susu M. Zughaier, Muhammad E. H. Chowdhury   +10 more
openalex   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Noninvasive serum biomarkers for liver fibrosis in NAFLD: current and future [PDF]

, 2022
Tina Reinson, Ryan Buchanan, Christopher D. Byrne   +2 more
openalex   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Robust training of recurrent neural networks to handle missing data for disease progression modeling [PDF]

, 2018
Disease progression modeling (DPM) using longitudinal data is a challenging task in machine learning for healthcare that can provide clinicians with better tools for diagnosis and monitoring of disease.
Cardoso, M. Jorge, Ghazi, Mostafa Mehdipour, Modat, Marc, Nielsen, Mads, Ourselin, Sebastien, Pai, Akshay, Sørensen, Lauge   +6 more
core   +1 more source

Prediction-based classification for longitudinal biomarkers

, 2010
Assessment of circulating CD4 count change over time in HIV-infected subjects on antiretroviral therapy (ART) is a central component of disease monitoring.
Azzoni, Livio, Foulkes, Andrea S., Johnson, Margaret A., Li, Xiaohong, Montaner, Luis J., Mounzer, Karam, Smith, Colette   +6 more
core   +1 more source

Citrullinated histone H3, a biomarker for neutrophil extracellular trap formation, predicts the risk of mortality in patients with cancer [PDF]

, 2019
Ella Grilz, Lisa‐Marie Mauracher, Florian Posch, Oliver Königsbrügge, Sabine Zöchbauer‐Müller, Christine Marosi, Iréne Lang, Ingrid Pabinger, Cihan Ay   +8 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source