Results 181 to 190 of about 2,058,753 (356)

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Fluctuations of terrestrial and marine biomarkers in the western tropical Pacific during the last 23,300 years [PDF]

, 1997
Naohiko Ohkouchi, Kimitaka Kawamura, Asahiko Taira   +2 more
openalex   +1 more source

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

Late Quaternary high‐resolution biomarker and other sedimentary climate proxies in a Northeast Atlantic Core [PDF]

, 1997
Luiz Augusto dos Santos Madureira, Shirley A van Kreveld, G. Eglinton, Maureen H. Conte, Gerald Ganssen, J.E. van Hinte, Janneke J. Ottens   +6 more
openalex   +1 more source

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

Nondestructive biomarkers in ecotoxicology.

, 1994
María Cristina Fossi
openalex   +1 more source

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

In vivo mutations in human blood cells: biomarkers for molecular epidemiology.

, 1993
Richard J. Albertini, Janice A. Nicklas, James C. Fuscoe, T R Skopek, Richard F. Branda, John P. O’Neill   +5 more
openalex   +1 more source

GDP‐fucose transporter SLC35C1: a potential regulatory role in cytosolic GDP‐fucose and fucosylated glycan synthesis

FEBS Open Bio, EarlyView.
The inactivation of SLC35C1 (GDP‐fucose transporter) and enzymes involved in GDP‐fucose biosynthesis was studied. Fucose supplementation increases the level of GDP‐fucose to abnormal, millimolar values in the absence of the TSTA3 protein and SLC35C1 in contrast to the GMDS/SLC35C1 double mutant.
Edyta Skurska, Mariusz Olczak
wiley   +1 more source

Biomarker selection in R: the BioMark package [PDF]

, 2012
BioMark is an R package implementing two meta-strategies for finding biomarkers. For two-class discrimination problems, Higher Criticism is available, an approach to define optimal cutoffs for methods like t testing for high-dimensional data. In this work, HC has been extended to multivariate methods, allowing, e.g., selection of biomarkers based on ...
Wehrens, Herman Ronald Maria Johan, Franceschi, Pietro   +1 more
openaire   +2 more sources