Results 191 to 200 of about 2,145,918 (335)

Evaluation of stress-inducible hsp90 gene expression as a potential molecular biomarker in Xenopus laevis [PDF]

, 1996
Adnan Hussein Ali, P.H. Krone, Derek Pearson, John J. Heikkila   +3 more
openalex   +1 more source

Biomarker selection in R: the BioMark package [PDF]

, 2012
BioMark is an R package implementing two meta-strategies for finding biomarkers. For two-class discrimination problems, Higher Criticism is available, an approach to define optimal cutoffs for methods like t testing for high-dimensional data. In this work, HC has been extended to multivariate methods, allowing, e.g., selection of biomarkers based on ...
Wehrens, Herman Ronald Maria Johan, Franceschi, Pietro   +1 more
openaire   +2 more sources

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

General practitioners' perspectives on blood biomarkers for Alzheimer's disease. [PDF]

Alzheimers Dement (Amst)
Claessen T, Visser FCW, van Munster BC, van der Flier WM, Jiménez-Mausbach M, van Harten AC, Teunissen CE, Visser LNC.   +7 more
europepmc   +1 more source

Biomarker Geochemistry of Triassic and Upper Jurassic Organic-Rich Shales and Associated Oil Staining, Barents Sea and Svalbard

, 1992
T. L. Leith
openalex   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Organisational impact and patient management models for biomarker integration in multiple sclerosis care in Italy: the 0Tolerance project. [PDF]

BMJ Neurol Open
Ragonese P, Buscarinu MC, Cellerino M, Colombo E, Frau J, Frigo M, Puthenparampil M, Rigoni E, Zancan V, Pinto L, Parretti S, Gazzaniga L.   +11 more
europepmc   +1 more source

Fluctuations of terrestrial and marine biomarkers in the western tropical Pacific during the last 23,300 years [PDF]

, 1997
Naohiko Ohkouchi, Kimitaka Kawamura, Asahiko Taira   +2 more
openalex   +1 more source

Age‐Related Changes in Myeloid Cells and Their Impact on Subcutaneous Melanoma Growth in Mice

Aging and Cancer, EarlyView.
Our findings reveal that age‐related changes in subcutaneous melanoma growth and immunotherapy response are context‐dependent. In models where tumor growth and treatment resistance increase with age, this effect is partly driven by enhanced immunosuppression from myeloperoxidase‐active Gr‐1⁺ myeloid cells.
Kaitlyn M. Landreth, Dylan D. Thomas, Remi Nohoesu, Angisha Basnet, F. Heath Damron, Mary Garland‐Kledzik, Emel Sen Kilic, Tracy W. Liu   +7 more
wiley   +1 more source