Results 211 to 220 of about 2,936,789 (384)

Unraveling the role of hypoxia-inducible factors in cutaneous melanoma: from mechanisms to therapeutic opportunities

Cell Communication and Signaling
Hypoxia is a common feature of solid malignancies, including cutaneous melanoma (CM). Hypoxia-inducible factor (HIF)-1α and HIF-2α orchestrate cellular responses to hypoxia and coordinate a transcriptional program that promote several aggressive features
Arianna Bellazzo, Barbara Montico, Roberto Guerrieri, Francesca Colizzi, Agostino Steffan, Jerry Polesel, Elisabetta Fratta   +6 more
doaj   +1 more source

Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy

Nature Reviews. Cancer, 2016
S. Topalian, J. Taube, R. Anders, D. Pardoll   +3 more
semanticscholar   +1 more source

Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam, Ali Laith, Aslihan Gunel, Melda Yilmaz, Nazli Basak, Halil Idrisoglu, P. Hande Ozdinler   +6 more
wiley   +1 more source

Improvement of enzyme-linked immunosorbent assay for the multicolor detection of biomarkers

, 2016
Chao Li, Yucai Yang, Dan Wu, Tianqi Li, Yongmei Yin, Genxi Li   +5 more
openalex   +2 more sources

Holocene changes in sea-ice cover and polynya formation along the eastern North Greenland shelf: New insights from biomarker records

, 2020
Nicole Syring, Ruediger Stein, Kirsten Fahl, Maximilian Vahlenkamp, Marc Zehnich, Robert F. Spielhagen, Frank Niessen   +6 more
openalex   +2 more sources

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann, Michelle M. Sonsalla, Cora Luzinski, Fernando Zacahua, David A. Harris, Dudley W. Lamming, Albee Messing   +6 more
wiley   +1 more source

Validation of biomarkers of aging

Nature Medicine
M. Moqri, Chiara M S Herzog, J. Poganik, Kejun Ying, Jamie N. Justice, D. Belsky, A. Higgins-Chen, Brian H. Chen, Alan A. Cohen, Georg Fuellen, S. Hägg, R. Marioni, Martin Widschwendter, Kristen Fortney, Peter O. Fedichev, Alex Zhavoronkov, N. Barzilai, J. Lasky-Su, Douglas P. Kiel, Brian K. Kennedy, Steven R Cummings, P. Slagboom, Eric Verdin, A. Maier, V. Sebastiano, Michael P. Snyder, V. Gladyshev, S. Horvath, L. Ferrucci   +28 more
semanticscholar   +1 more source

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

Lancet Neurology, 2010
C. Jack, D. Knopman, W. Jagust, L. Shaw, P. Aisen, M. Weiner, R. Petersen, J. Trojanowski   +7 more
semanticscholar   +1 more source

Interleukin‐6 as a Key Biomarker in Facioscapulohumeral Dystrophy: Evidence From Longitudinal Analyses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini, Emanuela Martinuzzi, Sandra Dhifallah, Abderhmane Slioui, Angela Puma, Luisa Villa, Michele Cavalli, Andra Ezaru, Jérémy Garcia, Manuela Gambella, Federico Torre, Luca Jacopo Pavan, Nicolas Glaichenhaus, Sabrina Sacconi   +13 more
wiley   +1 more source

Biomarkers in cancer [PDF]

Clinical Chemistry and Laboratory Medicine (CCLM), 2021
openaire   +2 more sources