Results 271 to 280 of about 1,486,593 (315)
Some of the next articles are maybe not open access.
Biomarkers of Immunosuppression
Critical Care Clinics, 2020It is now recognized that sepsis is not a uniformly proinflammatory state. There is a well-recognized counter anti-inflammatory response that occurs in many patients. The timing and magnitude of this response varies considerably and thus makes its identification and manipulation more difficult.
Abinav K, Misra +2 more
openaire +2 more sources
From biomarker strategies to biomarker activities and back
Drug Discovery Today, 2010The pharmaceutical industry must find ways to improve the unacceptably high attrition rate during drug development. Clearly, pharma has moved away from treat-and-see testing of new drugs in patients, with a strong current focus on generating translational biomarkers early in the research process to enable more predictive evaluation of drug action in ...
Gool, A.J. van +2 more
openaire +4 more sources
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 1988
Abstract This article presents a conceptual discussion of some aspects involved in biomarkers in aging. A biomarker of aging is a biological parameter of an organism that either alone or in some multivariate composite will, in the absence of disease, better predict functional capability at some late age than will chronological age.
openaire +3 more sources
Abstract This article presents a conceptual discussion of some aspects involved in biomarkers in aging. A biomarker of aging is a biological parameter of an organism that either alone or in some multivariate composite will, in the absence of disease, better predict functional capability at some late age than will chronological age.
openaire +3 more sources
Clinica Chimica Acta, 2015
Sepsis is the most frequent cause of death in non-coronary intensive care units (ICUs). In the past 10 years, progress has been made in the early identification of septic patients and in their treatment and these improvements in support and therapy mean that the mortality is gradually decreasing but it still remains unacceptably high.
Miroslav, Prucha +2 more
openaire +2 more sources
Sepsis is the most frequent cause of death in non-coronary intensive care units (ICUs). In the past 10 years, progress has been made in the early identification of septic patients and in their treatment and these improvements in support and therapy mean that the mortality is gradually decreasing but it still remains unacceptably high.
Miroslav, Prucha +2 more
openaire +2 more sources
2021
Biomarkers have been used in sepsis to assist with the diagnosis of disease as well as determining the severity of disease, that is, prognosis. These biomarkers are based on the presence of discrete molecules within the blood. Unfortunately, in 2020, a single biomarker does not have sufficient sensitivity and specificity to definitively rule in or rule
Yachana, Kataria, Daniel, Remick
openaire +2 more sources
Biomarkers have been used in sepsis to assist with the diagnosis of disease as well as determining the severity of disease, that is, prognosis. These biomarkers are based on the presence of discrete molecules within the blood. Unfortunately, in 2020, a single biomarker does not have sufficient sensitivity and specificity to definitively rule in or rule
Yachana, Kataria, Daniel, Remick
openaire +2 more sources
Current Medicinal Chemistry, 2007
Chronic Obstructive Pulmonary Disease is characterized by an abnormal inflammatory response of the lungs to noxious particles and gases, caused primarily by cigarette smoking. Although COPD affects the lung, it also produces significant systemic consequences.
Eleni G, Tzortzaki +3 more
openaire +2 more sources
Chronic Obstructive Pulmonary Disease is characterized by an abnormal inflammatory response of the lungs to noxious particles and gases, caused primarily by cigarette smoking. Although COPD affects the lung, it also produces significant systemic consequences.
Eleni G, Tzortzaki +3 more
openaire +2 more sources
Molecular Aspects of Medicine
Several biomarkers have been proposed to identify frailty, a multisystemic age-related syndrome. However, the complex pathophysiology and the absence of a consensus on a comprehensive and universal definition make it challenging to pinpoint a singular biomarker or set of biomarkers that conclusively characterize frailty.
Mariam, El Assar +3 more
openaire +2 more sources
Several biomarkers have been proposed to identify frailty, a multisystemic age-related syndrome. However, the complex pathophysiology and the absence of a consensus on a comprehensive and universal definition make it challenging to pinpoint a singular biomarker or set of biomarkers that conclusively characterize frailty.
Mariam, El Assar +3 more
openaire +2 more sources
Critical Care Clinics, 2018
A biomarker is a characteristic by which a (patho)physiologic process can be identified. Biomarkers can be of diagnostic value (to discriminate infection from noninfectious conditions or to determine the causative pathogen), of prognostic value (assigning risk profiles and predict outcome), and in the future may be of theranostic value (aid in ...
van Engelen, Tjitske S. R. +3 more
openaire +3 more sources
A biomarker is a characteristic by which a (patho)physiologic process can be identified. Biomarkers can be of diagnostic value (to discriminate infection from noninfectious conditions or to determine the causative pathogen), of prognostic value (assigning risk profiles and predict outcome), and in the future may be of theranostic value (aid in ...
van Engelen, Tjitske S. R. +3 more
openaire +3 more sources