Sensitivity of multi-parametric quantitative magnetic resonance imaging for multiple sclerosis pathology. [PDF]
Schlaeger S+14 more
europepmc +1 more source
Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease.
M. Mori+5 more
semanticscholar +1 more source
Abnormal Synchronization Between Cortical Delta Power and Ripples in Hippocampal Sclerosis
ABSTRACT Objective Discriminating between epileptogenic and physiological ripples in the hippocampus is important for identifying epileptogenic (EP) zones; however, distinguishing these ripples on the basis of their waveforms is difficult. We hypothesized that the nocturnal synchronization of hippocampal ripples and cortical delta power could be used ...
Takamitsu Iwata+10 more
wiley +1 more source
Liquid biopsy-derived extracellular vesicle protein biomarkers for diagnosis and prognostic assessment of lung squamous cell carcinoma. [PDF]
Ma S+11 more
europepmc +1 more source
Phase 1, First‐In‐Human, Single‐/Multiple‐Ascending Dose Study of Iluzanebart in Healthy Volunteers
ABSTRACT Objective To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of iluzanebart, a fully human monoclonal antibody TREM2 (triggering receptor expressed on myeloid cells 2) agonist, after single‐ (SAD) and multiple‐ascending‐dose (MAD) administration.
Andreas Meier+8 more
wiley +1 more source
Impact of Methodological Assumptions and Covariates on the Cutoff Estimation in ROC Analysis. [PDF]
Ghosal S.
europepmc +1 more source
Combination Therapy With Vigabatrin and Prednisolone Versus Vigabatrin Alone for Infantile Spasms
ABSTRACT Objective The study evaluated the effectiveness of combination therapy with vigabatrin and prednisolone versus vigabatrin alone for treating infantile epileptic spasms syndrome (IESS). Methods This single‐center, single‐blind, randomized trial enrolled infants aged 2–14 months with new‐onset IESS, randomly assigned them (1:1) to receive either
Rachata Boonkrongsak+6 more
wiley +1 more source
Misinterpretation and misapplication of biomarkers in inflammatory bowel disease: how do we avoid this? [PDF]
Varley RB, Lee JC.
europepmc +1 more source
Universal Proteomic Signature After Exercise‐Induced Muscle Injury in Muscular Dystrophies
ABSTRACT Objective Several neuromuscular disorders (NMDs) are characterized by progressive muscle damage and are marked by the elevation of circulating muscle proteins from activity‐related injury. Despite a diverse array of genetic drivers, many NMDs share similar patterns of exercise intolerance and higher concentrations of muscle injury proteins ...
Mads G. Stemmerik+5 more
wiley +1 more source