Results 31 to 40 of about 516,992 (264)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

User oriented access to secure biomedical resources through the grid [PDF]

, 2006
The life science domain is typified by heterogeneous data sets that are evolving at an exponential rate. Numerous post-genomic databases and areas of post-genomic life science research have been established and are being actively explored. Whilst many of
Watt, J, Ajayi, O, Jiang, J, Ajayi, O., Sinnott, R, Jiang, J., Sinnott, R.O., Stell, A, Stell, A.J., Watt, J.   +9 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Review of diverse optical fibers used in biomedical research and clinical practice

, 2014
Optical fiber technology has significantly bolstered the growth of photonics applications in basic life sciences research and in biomedical diagnosis, therapy, monitoring, and surgery.
Xiong, Fei, Cui, Ying, Shum, Perry Ping, Keiser, Gerd   +3 more
core   +1 more source

Creating clinically relevant, integrated cases in the biomedical and pharmaceutical sciences

The FASEB Journal, 2013
There is a body of convincing evidence that providing problem‐solving exercises in the form of patient cases can enhance student learning in the biomedical sciences. The challenge for basic scientists, however, is creating cases that are not only clinically relevant and scientifically based but also integrate concepts from various disciplines to ...
Robert Soltis, Nita Pandit
openaire   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Evaluation of a biomedical science clinical training curriculum [PDF]

, 2004
The thesis is concerned with quality in clinical education. It explores issues pertaining to the effectiveness of a biomedical science clinical training program through an evaluation.
Wong, Maria Wan-Yin
core  

Security and confidentiality approach for the Clinical E-Science Framework (CLEF)

, 2003
CLEF is an MRC sponsored project in the E-Science programme that aims to establish policies and infrastructure for the next generation of integrated clinical and bioscience research.
Detmer, D., Singleton, P., J Mackay, D Detmer, Royal Marsden Nhs Trust, D. Detmer, Ingram, D., D. Ingram, P. Singleton, Milan, J., Kalra, D., J Milan, A. Rector, D. Kalra, D Kalra, P Singleton, A Rector, Rector, A., Mackay, J., Kalra Singleton Ingram, J. Milan, D Ingram, J. MacKay   +22 more
core   +1 more source

Statistics in Biomedical Laboratory and Clinical Science: Applications, Issues and Pitfalls

Medical Principles and Practice, 2008
This review is directed at biomedical scientists who want to gain a better understanding of statistics: what tests to use, when, and why. In my view, even during the planning stage of a study it is very important to seek the advice of a qualified biostatistician.
openaire   +2 more sources