Results 51 to 60 of about 516,992 (264)

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

School of Veterinary Medicine & Biomedical Sciences: 2010 Annual Report

, 2010
On September 4, 2009, The Department of Veterinary Medicine and Biomedical Sciences was renamed the School of Veterinary Medicine and Biomedical Sciences.

core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Clinical and Biomedical Research: Positive prospects for the journal

, 2014
It is a great pleasure to present the second issue of Clinical and Biomedical Research and some of our work toward setting new standards for the journal.
Zavascki, Alexandre Prehn, Alexandre Prehn Zavascki   +1 more
core  

Trends in Citations to Books on Epidemiological and Statistical Methods in the Biomedical Literature [PDF]

, 2013
BackgroundThere are no analyses of citations to books on epidemiological and statistical methods in the biomedical literature. Such analyses may shed light on how concepts and methods changed while biomedical research evolved.
Jan P. Vandenbroucke (410557), Ioannidis, John P. A., Fernández, E, Vandenbroucke Jan P., Raj Bhopal (258306), Sergio Sanz (410558), Victora, Cesar, Porta Miquel, Sergio Sanz, Tomàs Lopez (410560), Miquel Porta, Fernández Muñoz, Esteve, Victora Cesar, Fernandez, Esteve, Cesar Victora (410559), Cesar Victora, Morabia Alfredo, Bhopal, Raj, Miquel Porta (199379), Sanz Sergio, Lopez Tomàs, Porta, Miquel, 1957-, Esteve Fernandez (3286209), Bhopal Raj, John P A Ioannidis, Esteve Fernandez, Morabia, A, Vandenbroucke, Jan P., Raj Bhopal, Alfredo Morabia, John P. A. Ioannidis (51405), Victora, C, Bhopal, R, Alfredo Morabia (64208), Fernandez Esteve, Sanz, Sergio, Morabia, Alfredo, Jan P Vandenbroucke, Lopez, Tomàs, Vandenbroucke, JP, Ioannidis, JPA, Porta, Miquel, Ioannidis John P. A., Tomàs Lopez   +43 more
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Statistics in the biomedical research and clinical strategy

, 2010
This paper presents some reflections on the biomedical and clinical research, from their origin to the present. A certain mathematic and statistic rationality may help to give a logical addition to the biomedical research and to change clinical strategy ...
Scardovi, Italo
core   +1 more source

Bridging medicine and biomedical technology: enhance translation of fundamental research to patient care [PDF]

, 2017
The ‘Bridging medicine and biomedical technology’ special all-congress session took place for the first time at the OSA Biophotonics Congress: Optics in Life Sciences in 2017 (http://www.osa.org/enus/meetings/osa_meetings/optics_in_the_life_sciences ...
Theo G. Seiler, Adam B. Raff, Apiou-Sbirlea, Gabriela, Gabriela Apiou-Sbirlea, Seiler, Günter Theodor Michael, Raff, Adam B.   +5 more
core   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source