Results 41 to 50 of about 1,049,437 (293)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Chinese Guidelines for the Diagnosis and Management of Atrial Fibrillation
Cardiology DiscoveryAtrial fibrillation (AF) is the most common sustained cardiac arrhythmia, significantly impacting patients’ quality of life and increasing the risk of death, stroke, heart failure, and dementia.
Chinese Society of Cardiology, Chinese Medical Association; Heart Rhythm Committee of Chinese Society of Biomedical Engineering
doaj +1 more source
Development and Transfer of Innovative Problem Solving Strategies and Related Confidence in Biomedical Engineering [PDF]
, 2019 Twenty-nine biomedical engineering (BME) undergraduates participated in a challenge-based instruction biotransport course, offered by the UT Austin BME Department in an accelerated format, at the University of Cambridge.
Clegg, John R., Diller, Kenneth R.
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Problem-Oriented Modelling for Biomedical Engineering Systems
Applied Sciences, 2022 Technical system (TS) models are widely used for setting and solving problems for the improvement of biomedical engineering systems beyond simple parameter optimisation. They mostly focus on system elements, the change or replacement of which can provide
Ivan Kernytskyy +11 more
doaj +1 more source
, 2006 https://digitalcommons.fiu.edu/bme_stats/1006/thumbnail ...
Department of Biomedical Engineering, Florida International University
core
Evaluation of cervical posture improvement of children with cerebral palsy after physical therapy based on head movements and serious games [PDF]
, 2016 Background: This paper presents the preliminary results of a novel rehabilitation therapy for cervical and trunk control of children with cerebral palsy (CP) based on serious videogames and physical exercise. Materials: The therapy is based on the use of
Cincotti, Febo +7 more
core +3 more sources
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Biomedical Engineering And Its Potential For Employment in Indonesia
International Journal of Technology, 2014 Indonesia, as cited by the World Health Organization (WHO), is still listed as one of the countries who spend less of its GDP on health services, despite the urgent need to overcome the high rate of medical cases in several diseases.
Maria Elfani, Narendra Kurnia Putra
doaj +1 more source