Results 61 to 70 of about 1,049,437 (293)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The biocompatibility of gallium-based liquid metals with blood and serum

iScience
Summary: Excellent biocompatibility of liquid metals is the basis for developing biomedical applications, such as implantable devices, drug delivery, and tumor therapy. Especially, a systematic study to reveal the influence of gallium-based liquid metals
Xinpeng Wang, Yingying He, Yudong Wu, Zhongshi Qi, Yongliang Wang, Junhang Ding, Jie Zhang, Yubo Fan, Hongzhang Wang   +8 more
doaj   +1 more source

A simulation study on the effects of neuronal ensemble properties on decoding algorithms for intracortical brain-machine interfaces [PDF]

, 2018
Background: Intracortical brain-machine interfaces (BMIs) harness movement information by sensing neuronal activities using chronic microelectrode implants to restore lost functions to patients with paralysis.
AP Georgopoulos, B Amirikian, Bongsoo Lee, C Chestek, CE Bouton, DM Taylor, E Salinas, G Santhanam, IH Stevenson, JE O’Doherty, Jeong-woo Sohn, JF Kalaska, JH Zar, JL Collinger, JM Carmena, JP Cunningham, JP Donoghue, LF Nicolas-Alonso, LR Hochberg, LR Hochberg, M Velliste, MA Lebedev, MD Serruya, Min-Ki Kim, PH Franses, PH Franses, RE Kass, S Koyama, S Musallam, S Waldert, SM Chase, SP Kim, SP Kim, Sung-Phil Kim, T Aflalo, V Gilja, W Shain, W Wu, X Zheng   +38 more
core   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Analysis of uncertainty and variability in finite element computational models for biomedical engineering:characterization and propagation

Frontiers in Bioengineering and Biotechnology, 2016
Computational modeling has become a powerful tool in biomedical engineering thanks to its potential to simulate coupled systems. However, real parameters are usually not accurately known and variability is inherent in living organisms. To cope with this,
Nerea Mangado, Gemma Piella, Jèrôme Noailly, Jordi Pons-Prats, Miguel Ángel González Ballester, Miguel Ángel González Ballester   +5 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Discovering Beaten Paths in Collaborative Ontology-Engineering Projects using Markov Chains [PDF]

, 2016
Biomedical taxonomies, thesauri and ontologies in the form of the International Classification of Diseases (ICD) as a taxonomy or the National Cancer Institute Thesaurus as an OWL-based ontology, play a critical role in acquiring, representing and ...
Musen, Mark A., Noy, Natalya F., Singer, Philipp, Strohmaier, Markus, Tudorache, Tania, Walk, Simon   +5 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Deep learning enhanced deciphering of brain activity maps for discovery of therapeutics for brain disorders

iScience
Summary: This study presents an artificial intelligence enhanced in vivo screening platform, DeepBAM, which enables deep learning of large-scale whole brain activity maps (BAMs) from living, drug-responsive larval zebrafish for neuropharmacological ...
Xianrui Zhang, Zhen Liu, Xuan Luo, Yi Cao, Wencong Zhang, Honglin Li, Wei Li, Shuk Han Cheng, Stephen J. Haggarty, Xin Wang, Peng Shi   +10 more
doaj   +1 more source

Multidisciplinary Learning Extends Communication Skill, and Helps Cross Cultural Understandings: Biomedical Engineering [PDF]

Journal of Systemics, Cybernetics and Informatics, 2017
The effects of multidisciplinary learning on extension of communication skill and on cross-cultural understandings have been discussed. "Biomedical engineering" is exemplified for the multidisciplinary field, which includes biology, medicine, engineering,
Shigehiro Hashimoto
doaj