Results 71 to 80 of about 677,625 (300)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Nano-Engineered Sensor Systems for Disease Diagnostics: Advances in Smart Healthcare Applications

Biosensors
Nano-engineered sensor systems represent a paradigm shift in disease diagnostics, offering unprecedented capabilities for precision medicine. This review methodically evaluates these advanced platforms, consolidating recent advancements across four ...
Tianjun Ma, Jianhai Sun, Ning Xue, Jamal N. A. Hassan, Adeel Abbas   +4 more
doaj   +1 more source

Remote monitoring of biodynamic activity using electric potential sensors [PDF]

, 2008
Previous work in applying the electric potential sensor to the monitoring of body electrophysiological signals has shown that it is now possible to monitor these signals without needing to make any electrical contact with the body.
C J Harl, Clippingdale A J, H Prance, Harland C J, Harland C J, Harland C J, Harland C J, Prance R J, R J Prance   +8 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Swellable Microneedles in Drug Delivery and Diagnostics

Pharmaceuticals
This manuscript explores the transformative potential of swellable microneedles (MNs) in drug delivery and diagnostics, addressing critical needs in medical treatment and monitoring. Innovations in hydrogel-integrated MN arrays facilitate controlled drug
Hossein Omidian, Sumana Dey Chowdhury
doaj   +1 more source

Wearable Biomedical Monitoring System Using TextileNet

2006 10th IEEE International Symposium on Wearable Computers, 2006
We developed and tested a biomedical monitoring system using TextileNet, a flexible conductive garment for wearable computing. TextileNet detects biological signals while simplifying communication and power supply wiring. TextileNet also acts as an electromagnetic interference (EMI) shield, which makes it possible to use simpler amplifiers in the ...
Masashi Toda, Junichi Akita, Shigeru Sakurazawa, Keisuke Yanagihara, Mihoko Kunita, Kunio Iwata   +5 more
openaire   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Micro-sized tunable liquid crystal optical filters

, 2017
Liquid Crystal Arrayed Microcavities (LCAM) is a new technology for ultra-narrow optical filtering (FWHM ~ 0.1 nm) that uses pico-liter volume Fabry-Perot type optical cavities filled with liquid crystal for tuning.
Atherton, David, Barber, Zeb, Barbour, Russell, Stoltzfus, Caleb   +3 more
core   +1 more source

Microwave imaging techniques for biomedical applications [PDF]

, 1999
Microwaves have been considered for medical applications involving the detection of organ movements and changes in tissue water content. More particularly cardiopulmonary interrogation via microwaves has resulted in various sensors monitoring ventricular
Bolomey, Jean Charles, Broquetas Ibars, Antoni, Geffrin, J M, Joachimowicz, N, Jofre Roca, Lluís, Joisel, A, Mallorquí Franquet, Jordi Joan, Vall-Llossera Ferran, Mercedes Magdalena, Vall·Llossera, M   +8 more
core   +1 more source