Results 61 to 70 of about 764,785 (295)

Formal axioms in biomedical ontologies improve analysis and interpretation of associated data

bioRxiv, 2019
Motivation There are now over 500 ontologies in the life sciences. Over the past years, significant resources have been invested into formalizing these biomedical ontologies.
F. Z. Smaili, Xin Gao, R. Hoehndorf
semanticscholar   +1 more source

Relations as patterns: bridging the gap between OBO and OWL

BMC Bioinformatics, 2010
Background Most biomedical ontologies are represented in the OBO Flatfile Format, which is an easy-to-use graph-based ontology language. The semantics of the OBO Flatfile Format 1.2 enforces a strict predetermined interpretation of relationship ...
Hoehndorf Robert, Oellrich Anika, Dumontier Michel, Kelso Janet, Rebholz-Schuhmann Dietrich, Herre Heinrich   +5 more
doaj   +1 more source

Ontology for Biomedical Investigations

Nature Precedings, 2009
AbstractThe goal of OBI is to enable a formal representation of biomedical investigations that captures the experimental evidence on which their findings are based. The scope of OBI includes: materials made in and produced for investigations, research objectives, experimental protocols, roles of people in investigations and processing and publication ...
Bjoern Peters, Bjoern Peters, The OBI Consortium   +2 more
openaire   +2 more sources

Towards Context Driven Modularization of Large Biomedical Ontologies [PDF]

, 2009
Formal knowledge about human anatomy, radiology or diseases is necessary to support clinical applications such as medical image search. This machine processable knowledge can be acquired from biomedical domain ontologies, which however, are typically ...
Pinar Wennerberg, Sonja Zillner
core   +2 more sources

Open Biomedical Ontology-based Medline exploration [PDF]

BMC Bioinformatics, 2009
Abstract Background Effective Medline database exploration is critical for the understanding of high throughput experimental results and the development of novel hypotheses about the mechanisms underlying the targeted biological processes.
Xuan, Weijian, Dai, Manhong, Mirel, Barbara, Song, Jean, Athey, Brian, Watson, Stanley J, Meng, Fan   +6 more
openaire   +3 more sources

The SWAN biomedical discourse ontology

Journal of Biomedical Informatics, 2008
Developing cures for highly complex diseases, such as neurodegenerative disorders, requires extensive interdisciplinary collaboration and exchange of biomedical information in context. Our ability to exchange such information across sub-specialties today is limited by the current scientific knowledge ecosystem's inability to properly contextualize and ...
Ciccarese, Paolo Nunzio, Wu, Elizabeth, Wong, Gwen, Ocana, Marco, Kinoshita, June, Ruttenberg, Alan, Clark, Tim   +6 more
openaire   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Building a biomedical ontology recommender web service

Journal of Biomedical Semantics, 2010
Background Researchers in biomedical informatics use ontologies and terminologies to annotate their data in order to facilitate data integration and translational discoveries.
Jonquet Clement, Musen Mark A, Shah Nigam H   +2 more
doaj   +1 more source

OPPL-Galaxy, a Galaxy tool for enhancing ontology exploitation as part of bioinformatics workflows [PDF]

, 2013
Biomedical ontologies are key elements for building up the Life Sciences Semantic Web. Reusing and building biomedical ontologies requires flexible and versatile tools to manipulate them efficiently, in particular for enriching their axiomatic content ...
Antezana, E., Egaña Aranguren, Mikel, Fernández-Breis, Jesualdo Tomás, Mungall, C., Rodríguez González, A., Wilkinson, M.   +5 more
core   +4 more sources

The National Center for Biomedical Ontology [PDF]

Journal of the American Medical Informatics Association, 2012
The National Center for Biomedical Ontology is now in its seventh year. The goals of this National Center for Biomedical Computing are to: create and maintain a repository of biomedical ontologies and terminologies; build tools and web services to enable the use of ontologies and terminologies in clinical and translational research; educate their ...
Mark A, Musen, Natalya F, Noy, Nigam H, Shah, Patricia L, Whetzel, Christopher G, Chute, Margaret-Anne, Story, Barry, Smith   +6 more
openaire   +2 more sources