Results 91 to 100 of about 123,356 (289)

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Application and Role of Ontologies in Biomedical Information Retrieval Systems

مجله انفورماتیک سلامت و زیست پزشکی, 2018
Introduction: Ontologies improve the quality of information retrieval (IR). Therefore, it is important to better know the process of ontology engineering and their application in IR.
Nader Alishan Karami, Mohsen Haji Zeinolabedini, Iraj Radad, Seyed Javad Ghazi-Mirsaeid   +3 more
doaj  

The Non-Coding RNA Ontology : a comprehensive resource for the unification of non-coding RNA biology [PDF]

, 2016
In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification.
Alan, Ruttenberg, Blake Judith, A., Dejing, Dou, Jingshan, Huang, Jun, Huan, Karen, Eilbeck, Natale Darren, A., Smith, Barry, Weili, Huang, Zimmermann Michael, T.   +9 more
core  

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source

The Ontology Lookup Service, a lightweight cross-platform tool for controlled vocabulary queries

BMC Bioinformatics, 2006
Background With the vast amounts of biomedical data being generated by high-throughput analysis methods, controlled vocabularies and ontologies are becoming increasingly important to annotate units of information for ease of search and retrieval.
Apweiler Rolf, Jones Philip, Côté Richard G, Hermjakob Henning   +3 more
doaj   +1 more source

An evolutionary approach to Function

, 2013
Background: Understanding the distinction between function and role is vexing and difficult. While it appears to be useful, in practice this distinction is hard to apply, particularly within biology.
Lord, Phillip
core   +1 more source

A Methodology for Biomedical Ontology Reuse [PDF]

, 2016
The abundance of biomedical ontologies is beneficial to the\ud development of biomedical related systems. However, existing biomedical\ud ontologies such as the National Cancer Institute Thesaurus (NCIT),\ud Foundational Model of Anatomy (FMA) and Systematized Nomenclature\ud of Medicine-Clinical Terms (SNOMED CT) are often too large to be\ud ...
Nur Zareen Zulkarnain, Farid Meziane, Gillian Crofts   +2 more
openaire   +1 more source

A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive‐Free, Topography‐Driven Osteogenesis

Advanced Healthcare Materials, EarlyView.
Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum, Leo A. H. Zeef, Lee A. Stevens, Marco A. N. Domingos, Susan J. Kimber, Mahetab H. Amer   +5 more
wiley   +1 more source

Improvement of PubMed Literature Searching using Biomedical Ontology [PDF]

, 2009
PubMed articles are annotated using the Medical Subject Headings (MeSH) to increase search efficiency. However, MeSH contains limited information on many biomedical domains (e.g., vaccine).
Yongqun He, Zuoshuang Xiang
core   +1 more source

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source