Results 81 to 90 of about 123,356 (289)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Constructing a lattice of Infectious Disease Ontologies from a Staphylococcus aureus isolate repository [PDF]
, 2012 A repository of clinically associated Staphylococcus aureus (Sa) isolates is used to semi‐automatically generate a set of application ontologies for specific subfamilies of Sa‐related disease.
Cowell, Lindsay G. +2 more
core +3 more sources
Advanced Engineering Materials, EarlyView.This article presents the NFDI‐MatWerk Ontology (MWO), a Basic Formal Ontology‐based framework for interoperable research data management in materials science and engineering (MSE). Covering consortium structures, research data management resources, services, and instruments, MWO enables semantic integration, Findable, Accessible, Interoperable, and ...
Hossein Beygi Nasrabadi +4 more
wiley +1 more source
Modulated evaluation metrics for drug-based ontologies
Journal of Biomedical Semantics, 2017 Background Research for ontology evaluation is scarce. If biomedical ontological datasets and knowledgebases are to be widely used, there needs to be quality control and evaluation for the content and structure of the ontology.
Muhammad Amith, Cui Tao
doaj +1 more source
Tissue Engineered Human Elastic Cartilage From Primary Auricular Chondrocytes for Ear Reconstruction
Advanced Functional Materials, EarlyView.Despite over three decades of research, no tissue‐engineered solution for auricular reconstruction in microtia patients has reached clinical translation. The key challenge lies in generating functional elastic cartilage ex vivo. Here, we integrate synergistic cell‐biomaterial strategies to engineer auricular grafts with mechanical and histological ...
Philipp Fisch +13 more
wiley +1 more source
Saliva Ontology: An ontology-based framework for a Salivaomics Knowledge Base
BMC Bioinformatics, 2010 Background The Salivaomics Knowledge Base (SKB) is designed to serve as a computational infrastructure that can permit global exploration and utilization of data and information relevant to salivaomics. SKB is created by aligning (1) the saliva biomarker
Smith Barry, David Wong T, Ai Jiye
doaj +1 more source
The management and integration of biomedical knowledge: Application in the health-e-child project (position paper) [PDF]
, 2006 The Health-e-Child project aims to develop an integrated healthcare platform for European paediatrics. In order to achieve a comprehensive view of children’s health, a complex integration of biomedical data, information, and knowledge ...
Bouquet +8 more
core +2 more sources
Advanced Functional Materials, EarlyView.A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam +8 more
wiley +1 more source
Architecture and usability of OntoKeeper, an ontology evaluation tool
BMC Medical Informatics and Decision Making, 2019 Background The existing community-wide bodies of biomedical ontologies are known to contain quality and content problems. Past research has revealed various errors related to their semantics and logical structure.
Muhammad Amith +6 more
doaj +1 more source
Discrete Dynamics in Nature and Society, 2020 Nowadays, most real-world decision problems consist of two or more incommensurable or conflicting objectives to be optimized simultaneously, so-called multiobjective optimization problems (MOPs).
Xingsi Xue, Xiaojing Wu, Junfeng Chen
doaj +1 more source