Results 91 to 100 of about 2,344,465 (331)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Humanidades Médicas, 2003 La ética de la experimentación con seres humanos no es sólo una de las áreas fundamentales de la bioética, sino también una de las problemáticas que le dieron origen.
Carlos M Albornoz López del Castillo +3 more
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Bridging the gaps in biomedical research [PDF]
BMJ, 2005 Science is the environment of different traditions unequally distributed throughout the world. Historically its development is deeply rooted in social and cultural process and often imbued with aspects of power, authority or control. Totalitarian dictatorships gave us variety of examples in the past but not even in democracies such examples were ...
openaire +4 more sources
F1000 recommendations as a new data source for research evaluation: A comparison with citations [PDF]
, 2013 F1000 is a post-publication peer review service for biological and medical research. F1000 aims to recommend important publications in the biomedical literature, and from this perspective F1000 could be an interesting tool for research evaluation.
Costas, Rodrigo, Waltman, Ludo
core +2 more sources
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
پیاورد سلامت, 2014 Background and Aim: The importance of social networking sites (SNSs) is evident as a tool for research team working and for enabling researchers to share the results and experiences.
Zahra Batooli, Maryam Nazari
doaj +2 more sources
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Российские биомедицинские исследования, 2022 На сегодняшний день разработано значительное количество способов и методик лечения пограничных ожоговых ран, включающих широкий спектр как лекарственных средств, так и физиотерапевтических воздействий.
Александр Владимирович Семиглазов +5 more
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