Results 81 to 90 of about 2,420,887 (329)
A comprehensive large scale biomedical knowledge graph for AI powered data driven biomedical research [PDF]
, 2023 Yuan Zhang +19 more
openalex +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Российские биомедицинские исследования, 2023 Одной из наиболее актуальных проблем современного здравоохранения является старение населения планеты и распространение ассоциированных со старением заболеваний.
И.А. Баранов +2 more
doaj
Undergraduate Research Fellows to Present Scientific Research at Annual SURF Conference on July 28 [PDF]
, 2017 Culminating a 10-week fellowship, 19 RWU students will present diverse research on the impact of climate change on the environment and biomedical ...
Public Affairs, Roger Williams University
core +1 more source
Statistics and Biomedical Research
Environmental Health Perspectives, 1979 Medical observations of leukemia or Hodgkin's disease clusters in time and space have led statisticians to invent techniques to evaluate the probability that these occurrences were due to chance. A difficult computation in human genetics was simplified by a matrix devised by a non-genetical statistician, and readily adapted to newly emerging computer ...
openaire +2 more sources
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Humanidades Médicas, 2003 La ética de la experimentación con seres humanos no es sólo una de las áreas fundamentales de la bioética, sino también una de las problemáticas que le dieron origen.
Carlos M Albornoz López del Castillo +3 more
doaj
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source