Results 81 to 90 of about 2,344,465 (331)
Alliance for biomedical research in Europe
EMBO Molecular Medicine, 2011 Europe is facing one of the most challenging times in its history, with austerity measures being applied across member states that are leaving research programmes in uncertain territory. Funding for European research and development (R&D) programmes remains stagnant at 1.8% of European Union GDP, well short of the 3.0% that was committed to in the ...
Smith, Ulf +3 more
openaire +4 more sources
Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs
Molecular Oncology, EarlyView.In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza +3 more
wiley +1 more source
Undergraduate Research Fellows to Present Scientific Research at Annual SURF Conference on July 28 [PDF]
, 2017 Culminating a 10-week fellowship, 19 RWU students will present diverse research on the impact of climate change on the environment and biomedical ...
Public Affairs, Roger Williams University
core +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
СИБИРСКАЯ ЯЗВА: БИОЛОГИЧЕСКИЕ ОСОБЕННОСТИ ВОЗБУДИТЕЛЯ
Российские биомедицинские исследования, 2023 Сибирская язва (антракс) — заболевание, известное с древних времен. Оно относится к особо опасным инфекциям с высокой летальностью, достигающей при несвоевременной диагностике и отсутствии этиотропной терапии 90%, а при легочной форме инфекции — 100 ...
Н.С. Козлова +3 more
doaj
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer
Molecular Oncology, EarlyView.Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla +15 more
wiley +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Lasker Foundation: 2014 Annual Report [PDF]
, 2015 Lasker Foundation 2014 Annual Report, highlighting this years achievements which include, the leadership of the Foundation, current scientific advances and the importance of sustained support for biomedical ...
core