Results 61 to 70 of about 502,307 (287)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Bandlets on Oriented Graphs: Application to Medical Image Enhancement

IEEE Access, 2019
In this paper, we introduce a new image modeling method by getting benefit from both sparsity and multiscale characteristics of transform-domain modeling, along with the geometrical representation of the graph-based models.
Rahele Kafieh, Hossein Rabbani, Gozde Unal   +2 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

6DOF Needle Pose Estimation for Robot-Assisted Vitreoretinal Surgery

IEEE Access, 2019
Vitreoretinal (VR) surgery is typical microsurgery with delicate and complex surgical procedures. The vision-based navigation for robot-assisted VR surgery has not been fully exploited because of the challenges that arise from illumination, high ...
Mingchuan Zhou, Xing Hao, Abouzar Eslami, Kai Huang, Caixia Cai, Chris P. Lohmann, Nassir Navab, Alois Knoll, M. Ali Nasseri   +8 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

An Energy-Efficient Biomedical Signal Processing Platform [PDF]

IEEE Journal of Solid-State Circuits, 2010
This paper presents an energy-efficient processing platform for wearable sensor nodes, designed to support diverse biological signals and algorithms. The platform features a 0.5V-1.0V 16b microcontroller, SRAM, and accelerators for biomedical signal processing.
Kwong, Joyce, Chandrakasan, Anantha P.
openaire   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Serious gaming and eye-tracking for the screening, monitoring, and diagnosis of neurodevelopmental disorders in children: a systematic literature review

Frontiers in Bioengineering and Biotechnology
Neurological development between the ages of 3–11 is crucial to the shaping of infrastructural capabilities like the executive functions that enable the child to achieve academically and socially.
Muhammad Farooq Shaikh, Ciara Higley, Cecilia Campanile, Rebecca Francis, Elyssa Panja, Silvia Santacaterina, Giacomo Pratesi, Davide Piaggio   +7 more
doaj   +1 more source

Development of a new sequential block finding strategy for detection of conserved sequences in riboswitches [PDF]

BioImpacts, 2018
Introduction: Some non-coding RNAs have an important role in the regulation of gene expression and consequently cellular function. Riboswitches are examples of these regulatory RNAs.
Faegheh Golabi, Mousa Shamsi, Mohammad Hosein Sedaaghi, Abolfazl Barzegar, Mohammad Saeid Hejazi   +4 more
doaj   +1 more source