Results 81 to 90 of about 502,307 (287)
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The ClassA Framework: HRV Based Assessment of SNS and PNS Dynamics Without LF-HF Controversies
Frontiers in Physiology, 2019 The powers of the low frequency (LF) and high frequency (HF) components of heart rate variability (HRV) have become the de facto standard metrics in the assessment of the stress response, and the related activities of the sympathetic nervous system (SNS)
Tricia Adjei +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Current Directions in Biomedical Engineering, 2019 This work presents a new system concept for the prevention, diagnosis and interactive treatment of neck pain. It comprises two measurement units worn at the head and the torso, a smartphone/tablet and a medical assistance software.
Tadayon Puian +3 more
doaj +1 more source
Efficient design of FIR filter based low-pass differentiators for biomedical signal processing
Current Directions in Biomedical Engineering, 2016 This paper describes an alternative design of linear phase low-pass differentiators with a finite impulse response (type III FIR filter). To reduce the number of necessary filter coefficients, the differentiator’s transfer function is approximated by a ...
Wulf Michael +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
A comprehensive survey on the biomedical signal processing methods for the detection of COVID-19. [PDF]
Ann Med Surg (Lond), 2022 Anand S, Sharma V, Pourush R, Jaiswal S.
europepmc +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Ultra-Resolution Spectral Correction Based on Adaptive Linear Neuron for Biomedical Signal Processing. [PDF]
Front Public Health, 2021 Chen B, Zheng B, Sun W.
europepmc +1 more source