Results 31 to 40 of about 12,850,910 (306)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Patient and public involvement in health technology decision-making processes in Brazil

Revista de Saúde Pública, 2020
OBJECTIVE The study aims to characterize and discuss the processes of patient and public involvement (PPI) in the Brazilian Health Regulatory Agency (Anvisa), the National Committee for Health Technology Incorporation (Conitec), and the National Agency ...
Ana Carolina de Freitas Lopes, Hillegonda Maria Dutilh Novaes, Patricia Coelho de Soárez   +2 more
doaj   +2 more sources

Technology Assessment in Business and Government [PDF]

, 1977
Hearings held by the Office of Technology Assessment (OTA) with the purpose of developing "a better understanding of how the processes of technology assessment have affected decisionmaking in the public and private sectors" (p.1)
United States. Congress. Office of Technology Assessment.
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Rectus sheath hematoma in patients receiving subcutaneous enoxaparin: A case series of five patients

Clinical Case Reports, 2020
Physicians must acknowledge the potential risk of RSH with enoxaparin. Switching home anticoagulation by enoxaparin upon hospital admission is common, but it may put patients at higher risk for RSH. Management guidelines are needed in this setting.
Diogo Mendes, Ana Penedones, Michele Martins, Susana Cavadas, Carlos Alves, Francisco Batel‐Marques   +5 more
doaj   +1 more source

The Implications of Cost-Effectiveness Analysis of Medical Technology [PDF]

, 1980
A case study by the Office of Technology Assessment (OTA) that "touches on only some of the aspects of technology assessment that might be undertaken with respect to multichannel chemistry analyzers" (p. 7)
United States. Congress. Office of Technology Assessment.
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Improvement of medical content in the curriculum of biomedical engineering based on assessment of students outcomes

BMC Medical Education, 2017
Background Improvement of medical content in Biomedical Engineering curricula based on a qualitative assessment process or on a comparison with another high-standard program has been approached by a number of studies. However, the quantitative assessment
Enas Abdulhay, Ruba Khnouf, Shireen Haddad, Areen Al-Bashir   +3 more
doaj   +1 more source

Discrimination between healthy and patients with Parkinson’s disease from hand resting activity using inertial measurement unit

BioMedical Engineering OnLine, 2021
Background Parkinson’s disease (PD) is a neurological disease that affects the motor system. The associated motor symptoms are muscle rigidity or stiffness, bradykinesia, tremors, and gait disturbances.
Luciano Brinck Peres, Bruno Coelho Calil, Ana Paula Sousa Paixão Barroso da Silva, Valdeci Carlos Dionísio, Marcus Fraga Vieira, Adriano de Oliveira Andrade, Adriano Alves Pereira   +6 more
doaj   +1 more source