Results 31 to 40 of about 578,412 (294)
Early stage Health Technology Assessment (HTA) of biomedical devices. The MATCH experience [PDF]
, 2013 Early stage Health Technology Assessment (HTA) of biomedical devices requires different methods than those usually employed for pharmaceuticals. This paper reviews widely used methods for HTA, discusses their limits for early stage evaluation of biomedical devices and presents two methods for early stage HTA being developed in the Multidisciplinary ...
Pecchia, Leandro, Craven, Michael P.
openaire +2 more sources
BMJ Open, 2020 Introduction Janus kinases (JAK) inhibitors demonstrated to be effective in the treatment of adult patients with moderate-to-severe active rheumatoid arthritis (RA) but have been associated with serious cardiovascular and serious events.
Francisco Batel-Marques +3 more
doaj +1 more source
The Application of Integrated Knowledge-based Systems for the Biomedical Risk Assessment Intelligent Network (BRAIN) [PDF]
, 1993 One of NASA's goals for long duration space flight is to maintain acceptable levels of crew health, safety, and performance. One way of meeting this goal is through the Biomedical Risk Assessment Intelligent Network (BRAIN), an integrated network of both
Culbert, Chris +8 more
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Health Technology Assessment: informed by science or in the service of politics?
Revista de Saúde Pública, 2021 The youth of Health Technology Assessment (HTA), as an institutional policy at the national level, signals the need to reflect on how its implementation took place under the perspective of its insertion in health policy and the scientific field.
Patrícia Coelho De Soárez
doaj +2 more sources
Developing students' information and research skills via Blackboard [PDF]
, 2007 This paper summarizes work undertaken at De Montfort University (Leicester, UK) to develop students’ information and research skills using the Blackboard Virtual Learning Environment.
DaCosta, Jacqui, Jones, Becky
core +4 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Sociology of low expectations: Recalibration as innovation work in biomedicine [PDF]
, 2015 "This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the ...
Brown Nik +11 more
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Number needed to treat (NNT) in clinical literature: an appraisal
BMC Medicine, 2017 Background The number needed to treat (NNT) is an absolute effect measure that has been used to assess beneficial and harmful effects of medical interventions.
Diogo Mendes +2 more
doaj +1 more source