Results 51 to 60 of about 12,850,910 (306)

Artificial Intelligence Search Tools for Evidence Synthesis: Comparative Analysis and Implementation Recommendations

Cochrane Evidence Synthesis and Methods
To inform implementation recommendations for novel or emerging technologies, Research Information Services at Canada's Drug Agency conducted a multimodal research project involving a literature review, a retrospective comparative analysis, and a focus ...
Robin Featherstone, Melissa Walter, Danielle MacDougall, Eric Morenz, Sharon Bailey, Robyn Butcher, Caitlyn Ford, Hannah Loshak, David Kaunelis   +8 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Office of Technology Assessment (OTA) Resources, February 1995

, 1995
This collection of Office of Technology Assessment (OTA) Resources information briefs details assessments and documents completed by OTA and categorized into a variety of topics, including the proliferation of weapons of mass destruction, defense ...
Office of Technology Assessment
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ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Hepatotoxic effects of inhalation exposure to polycyclic aromatic hydrocarbons on lipid metabolism of C57BL/6 mice

Environment International, 2020
Inhalation from ambient air and cigarette smoke is a common route of human exposure to polycyclic aromatic hydrocarbons (PAHs). Little information is available regarding hepatotoxicities of inhaled PAHs so for.
Fang Li, Binbin Xiang, Yan Jin, Chao Li, Songlei Ren, Yongning Wu, Jingguang Li, Qian Luo   +7 more
doaj   +1 more source

Office of Technology Assessment List of Publications, April 1980

, 1980
A catalog of Office of Technology Assessment (OTA) documents published through ...
Office of Technology Assessment
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Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Office of Technology Assessment List of Publications, January 1987

, 1987
A catalog of Office of Technology Assessment (OTA) documents published through ...
Office of Technology Assessment
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Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Office of Technology Assessment List of Publications, January 1993

, 1993
A catalog of Office of Technology Assessment (OTA) documents published through ...
Office of Technology Assessment
core