Results 51 to 60 of about 228,668 (300)

Fatores associados a sintomas depressivos em idosos atendidos em ambulatório público de Geriatria

Revista Brasileira de Geriatria e Gerontologia
OBJETIVO: Investigar fatores biopsicossociais associados à presença de sintomatologia depressiva em idosos atendidos em ambulatório público de Geriatria, na cidade do Rio de Janeiro, Brasil.
Patrícia Diógenes Suassuna, Renato Peixoto Veras, Roberto Alves Lourenço, Célia Pereira Caldas   +3 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Patient and public involvement in health technology decision-making processes in Brazil

Revista de Saúde Pública, 2020
OBJECTIVE The study aims to characterize and discuss the processes of patient and public involvement (PPI) in the Brazilian Health Regulatory Agency (Anvisa), the National Committee for Health Technology Incorporation (Conitec), and the National Agency ...
Ana Carolina de Freitas Lopes, Hillegonda Maria Dutilh Novaes, Patricia Coelho de Soárez   +2 more
doaj   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Ontology-based document representation for biomedical information retrieval [PDF]

, 2007
In the current era of fast sequencing of entire genomes, more data is becoming available for analysis. This data analysis, in turn, leads to an increasing amount of scientfic publications.
Camous, Fabrice
core  

Conceptual model for early health technology assessment of current and novel heart valve interventions [PDF]

, 2016
Advances in the field of heart valve interventions, like tissue-engineered heart valves (TEHV). Prior to introduction in clinical practice, it is essential to perform early health technology assessment.
Kappetein, A.P. (Arie Pieter), DeJaegere, P.P.T. (Peter P. T.), Kluin, J., Bouten, CVC, Versteegh, MIM, Chamuleau, S.A.J., Kluin, J, Kappetein, Arie-Pieter, Huygens, Simone, Chamuleau, SAJ, Bogers, A.J.J.C., Molken, Maureen; id_orcid, Versteegh, M. (Michel), Huygens, S.A., Witsenburg, Maarten, Takkenberg, J.J.M., Rutten-van Mölken, M.P.H.M., Takkenberg, Hanneke, Bouten, C.V.C. (Carlijn), Kluin, J. (Jolanda), Takkenberg, J.J.M. (Hanneke), Mieghem, van, N.M.D.A., Bouten, C.V.C.; id_orcid, Rutten-van Mölken, M.P.M.H. (Maureen), Chamuleau, S.A.J. (Steven), Witsenburg, M. (Maarten), Bogers, Ad; id_orcid, Bouten, C.V.C., Versteegh, M.I.M., Bekkers, J.A. (Jos), DeJaegere, P.P.T., Jaegere, Peter, Molken, Maureen, Mieghem, Nicolas, Huygens, S.A. (Simone), Bogers, Ad, Mieghem, N.M. (Nicolas) van, Kappetein, A.P., Witsenburg, M., Bogers, A.J.J.C. (Ad), Bekkers, J.A., Bekkers, Jos   +41 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The future of best investing in vaccines: the Health Technology Assessment approach

, 2008
Over the past two decades, scientific research has led to the development of a huge number of new health technologies, among which new vaccines. The decision process underlying the introduction of a new vaccine will be of particular concern in the future
Specchia, Maria Lucia, Nicolotti, Nicola, Ricciardi, Walter, La Torre, Giuseppe, Chiaradia, Giacomina, De Waure, Chiara, Mannocci, Alice, Ricciardi, Gualtiero   +7 more
core   +1 more source

Discrimination between healthy and patients with Parkinson’s disease from hand resting activity using inertial measurement unit

BioMedical Engineering OnLine, 2021
Background Parkinson’s disease (PD) is a neurological disease that affects the motor system. The associated motor symptoms are muscle rigidity or stiffness, bradykinesia, tremors, and gait disturbances.
Luciano Brinck Peres, Bruno Coelho Calil, Ana Paula Sousa Paixão Barroso da Silva, Valdeci Carlos Dionísio, Marcus Fraga Vieira, Adriano de Oliveira Andrade, Adriano Alves Pereira   +6 more
doaj   +1 more source