Results 61 to 70 of about 578,412 (294)

Effectiveness in clinical practice versus efficacy of dipeptidyl peptidase-4 inhibitors in clinical trials for type 2 diabetes: protocol for systematic review

BMJ Open, 2019
Introduction Data supporting the use of oral antidiabetic drugs mainly rely on data from premarketing clinical trials. Real-world data studies are crucial to evaluate effectiveness of drugs.
Francisco Batel-Marques, Diogo Pereira, Diogo Mendes, Ana Penedones   +3 more
doaj   +1 more source

Enhancing Scientific Communication Skills: a Real-World Simulation in a Tertiary-Level Life Science Class Using E-Learning Technology in Biomedical Literature Perception, Reflective Review Writing on a Clinical Issue, and Self and Peer Assessments [PDF]

Research in Science Education, 2018
This educational study aimed to explore the feasibility and acceptance of a literacy exercise adopted from the realworld of scientific publishing in a cell and tissue biology course. For that purpose, a tertiary-level multimodality science course, which integrated a blended learning faculty and student lectures, journal club, and wet laboratory ...
Elisabeth Eppler, Jan Meyer, Steffen Serowy, Karl Link, Barbara Pauk, Luis Filgueira   +5 more
openaire   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Aceptabilidad de una intervención basada en Salud Móvil para modificar estilos de vida en prehipertensos de Argentina, Guatemala y Perú: un estudio piloto

Revista Peruana de Medicina Experimental y Salud Pública
Objetivos. Evaluar la aceptabilidad y factibilidad de una intervención basada en salud móvil, para la adopción de estilos de vida saludables en personas prehipertensas que viven en zonas urbanas de bajos recursos en Argentina, Guatemala y Perú ...
Andrea Beratarrechea, Francisco Diez-Canseco, Ariel Fernández, Rebeca Kanter, Paola Letona, Homero Martinez, J. Jaime Miranda, Manuel Ramirez-Zea, Adolfo Rubinstein   +8 more
doaj   +2 more sources

Impact Factor: outdated artefact or stepping-stone to journal certification?

, 2011
A review of Garfield's journal impact factor and its specific implementation as the Thomson Reuters Impact Factor reveals several weaknesses in this commonly-used indicator of journal standing.
A Andrade, A Bonillo Perales, A Coleman, A Fassoulaki, A Lomnicki, A Schubert, A Tal, AI Pudovkin, Anonymous, AP Kurmis, AP Kurmis, AR Weale, AW Jones, AW Jones, B Cashore, B Statzner, B Stiftel, B Timuralp, BD Cameron, BM Althouse, C Chen, C Johnson, C McGarty, C Minelli, C Neuhaus, C Scully, CM Ketcham, CP Robert, CR Bain, CW Holsapple, D Ho, D Leutner, D Poomkottayil, D Schoonbaert, D Ugolini, DB Resnik, DB Resnik, DC Greenwood, DE Drew, DN Laband, DR Smith, DW Straub, E Archambault, E Garfield, E Garfield, E Garfield, E Garfield, E Postma, E Wager, EJ Favaloro, EM Sonderstrup-Andersen, EV Bernstam, F Godlee, F Habibzadeh, F Preti, F-T Krell, FJ Bath, FN Dost, G Abramo, G Jacobs, G Knothe, G Lehmkuhl, G Maier, G Racki, G Walter, G Williams, G Winkmann, G Winkmann, G Yu, G Yu, GE Hunt, H Brown, H Goldstein, H Moed, H Sompel Van de, H Xiao, HB Hansen, HF Moed, I Chalmers, I Hames, J Awrey, J Bollen, J Cheek, J Davies, J Horner, J Kapeller, J Mehrad, J Mehrad, J Moller, J Reedijk, J Roberts, J Schopfel, J Woelfel, JA Dempsey, JB Cohen, Jerome K. Vanclay, JJ Ramsden, JK Vanclay, JL Wulff, JM Campanario, JM Campanario, JM Campanario, JP Skovsgaard, JS Kotiaho, JYA Foo, JYA Foo, K Metze, K Simons, K Soreide, KG Altmann, L Bornmann, L Eaton, L Gollogly, L Leydesdorff, L McKeever, L Rieseberg, L Rieseberg, LL Gluud, LL Lange, M Callaham, M Callaham, M Chew, M Driel Van, M Errami, M Errami, M Frank, M Jahangiriana, M Patterson, M Porter, M Rossner, M Rossner, M Taylor, M-J Johnstone, MA Hernan, MA Ruiz, MC Calver, ME Falagas, ME McVeigh, MF Fox, MJ Cobo, MJ Tobin, MV Simkin, N Haslam, N Rezaei-Ghaleh, N Sombatsompop, N Sombatsompop, P Abraham, P Campbell, P Dong, P Jacso, P Jörgensen, P Owlia, PA Lawrence, PA Todd, PA Todd, PC Gøtzsche, PLoS Medicine Editors, PO Seglen, PO Seglen, PO Seglen, R Adler, R Coleman, R Meneghini, R Rousseau, R Rousseau, R Saunders, R Zetterstrom, RA Brumback, RA Brumback, RJ Epstein, RJ Stein, RP Vlosky, RW Glynn, S Butakov, S Chapman, S Lock, S Meyer zu Eissen, S Saha, S Wang, S Woolgar, SE Gwilym, SJ Bensman, SJ Bensman, SJ Bensman, SL Lau, T Braun, TC Ha, TH Berquist, TL Ogden, TN Leeuwen Van, TP Kurmis, TV Perneger, V Barbour, V Kumar, V Larivière, VA Cartwright, W Glänzel, W Glänzel, W Yue, WH Starbuck, WR Schumm, WT Obremskey   +201 more
core   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Somatosensory and nociceptive changes in chronic post-stroke shoulder pain [PDF]

, 2008
Preliminary results from a cross-sectional study that investigated the relation between the presence of post-stroke shoulder pain and somatosensory and nociceptive changes are presented.
Buitenweg, J.R., Dongen, R.T.M. van, Geurts, A.C.H., IJzerman, M.J., Renzenbrink, G.J., Roosink, M.   +5 more
core   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Evaluación de tecnologías diagnósticas: conceptos básicos en un estudio con muestreo transversal Assessing a diagnostic test: basic concepts in a study with naturalistic sampling

Revista Colombiana de Obstetricia y Ginecología, 2007
Los estudios de evaluación de pruebas diagnósticas son un diseño científico que nos ayuda a determinar la validez y la reproducibilidad de los procedimientos que pueden ser usados en la práctica clínica por médicos y otros profesionales de salud. Este es
María Isabel Castro-Jiménez, Daladier Cabrera-Rodríguez, Miguel Ángel Castro-Jiménez   +2 more
doaj  

Artificial Intelligence Search Tools for Evidence Synthesis: Comparative Analysis and Implementation Recommendations

Cochrane Evidence Synthesis and Methods
To inform implementation recommendations for novel or emerging technologies, Research Information Services at Canada's Drug Agency conducted a multimodal research project involving a literature review, a retrospective comparative analysis, and a focus ...
Robin Featherstone, Melissa Walter, Danielle MacDougall, Eric Morenz, Sharon Bailey, Robyn Butcher, Caitlyn Ford, Hannah Loshak, David Kaunelis   +8 more
doaj   +1 more source