Results 71 to 80 of about 225,042 (258)

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source

Artificial Intelligence for Organoids Multidimensional Assessment

SmartMat
Organoids are tissue analogues formed through in vitro three‐dimensional culture of stem cells, possessing specific spatial structures. Organoids have become integral to various biomedical fields, including disease pathogenesis, model construction ...
Yulin Mo, Jian Wang, Huijian Yang, Long Bai, Ke Xu, Jiacan Su   +5 more
doaj   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Eficácia e Segurança do Blinatumomabe no Tratamento da Leucemia Linfoblástica Aguda: Revisão Sistemática da Literatura

Revista Brasileira de Cancerologia
Introdução: As opções de tratamento convencionais para leucemia linfoblástica aguda (LLA) são a quimioterapia, a transfusão de sangue e o transplante de medula óssea.
Renan do Nascimento Gonçalves, Aline Nascimento, Raphael Duarte Chança, Laura Augusta Barufaldi   +3 more
doaj   +1 more source

Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto, Umberto Pensato, Ilaria Casetta, Giorgio U. Marcello, Angelo Barra, Anna Poggesi, Edoardo Carlesi, Sara Mancini, Andrea Ginestroni, Vittorio Miele, Alessandro Padovani, Andrea Morotti, Enrico Fainardi   +12 more
wiley   +1 more source

Bioética e avaliação tecnológica em saúde

Cadernos de Saúde Pública
A vigência simultânea do paradigma biotecnocientífico (que incentiva a incorporação tecnológica) e da cultura dos limites (que seleciona as tecnologias) constitui um grande desafio aos sistemas sanitários atuais, suscitando debates éticos e políticos ...
Fermin Roland Schramm, Claudia Caminha Escosteguy   +1 more
doaj   +2 more sources

Radiotherapy and diagnostic capacity in relation to the changing cancer burden in the Baltic States

Acta Oncologica
Background and purpose: Cancer mortality rates in the Baltic States (Estonia, Latvia, and Lithuania) exceeds the European Union (EU) average, in part due to limited access to radiation therapy (RT).
Erika Korobeinikova, Kristaps Paļskis, Manjit Dosanjh, Freddie Bray, Eduard Gershkevitsh, Inga Balode, Alvis Bernans, Gaļina Boka, Laimonas Jaruševičius, Zanda Liepa, Māris Mežeckis, Aista Plieskienė, Maija Radziņa, Romas Skomskis, Giedrė Smailytė, Sandra Stepiņa, Jonas Venius   +16 more
doaj   +1 more source

Assessment of Computerized Medical Equipment Management and Maintenance System from HTA perspective: Need and Approach

Health Technology Assessment in Action, 2021
For providing quality health care proper management of medical equipments is important. A computerized maintenance management system (CMMS) is a software package used by healthcare technology management (HTM) programs as a tool to manage, organize ...
Dr. Nitin Kumar Joshi, Pankaj Bhardwaj, Kuldeep Singh, Vibha Joshi, Praveen Suthar   +4 more
doaj