Results 151 to 160 of about 90,813 (262)

From the Proteome to Therapeutics: A Multi‐Database Approach to Drug Discovery in Periodontitis—An Exploratory Pilot Study

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Introduction This explanatory pilot study presents a workflow to identify approved drugs, which could be repurposed for periodontitis therapy using salivary proteomics combined with drug‐target database screening. Methods Proteomic analyses of saliva using LC–MS/MS were conducted in two independent settings: a cohort (sub‐study I, N = 187) and
Taisir Bozo, Annette Murr, Birte Holtfreter, Sebastian‐Edgar Baumeister, Peter Meisel, Uwe Völker, Werner Weitschies, Henry Völzke, Philipp Kanzow, Elke Hammer, Manuela Gesell Salazar, Thomas Kocher   +11 more
wiley   +1 more source

FamPlex: a resource for entity recognition and relationship resolution of human protein families and complexes in biomedical text mining. [PDF]

BMC Bioinformatics, 2018
Bachman JA, Gyori BM, Sorger PK.
europepmc   +1 more source

Arabidopsis inositol polyphosphate kinase activities regulate COP9 deneddylation functions in phosphate homeostasis

Journal of Integrative Plant Biology, EarlyView.
Plant phosphate (Pi) homeostasis relies on coordinated activities of the inositol polyphosphate kinases IPK1 and ITPK1, which balance localized InsP7 biosynthesis to control COP9 signalosome (CSN)‐dependent deneddylation of cullin 1 (CUL1). Perturbation of this equilibrium affects the stability of SPX4, a key negative regulator of phosphate starvation ...
Yashika Walia, Medha Noopur, Ishana Bhattacharya, Bhaskar Chandra Sahoo, Mritunjay Kasera, Naga Jyothi Pullagurla, Smritikana Dutta, Guizhen Liu, Gabriel Schaaf, Henning Jessen, Debabrata Laha, Souvik Bhattacharjee, Saikat Bhattacharjee   +12 more
wiley   +1 more source

Pressing needs of biomedical text mining in biocuration and beyond: opportunities and challenges. [PDF]

Database (Oxford), 2016
Singhal A, Leaman R, Catlett N, Lemberger T, McEntyre J, Polson S, Xenarios I, Arighi C, Lu Z.   +8 more
europepmc   +1 more source

A Novel Framework for Biomedical Text Mining

Journal on Big Data, 2020
Janyl Jumadinova, Oliver Bonham-Carter, Hanzhong Zheng, Michael Camara, Dejie Shi   +4 more
openaire   +1 more source

Whose knowledge, whose cure? traditional medicine and the boundaries of WIPO's 2024 genetic resources treaty

The Journal of World Intellectual Property, EarlyView.
Abstract Traditional medicine—including complementary, integrative, Indigenous, and ancestral practices—remains a vital source of healthcare for billions worldwide, particularly in the Global South. Despite its widespread use and biomedical relevance, traditional medicinal knowledge has long been excluded from dominant intellectual property systems ...
Tolulope Anthony Adekola
wiley   +1 more source

Extracting vitalities: Cuts in Indigenous women's bodies‐territories (Brazil)

Medical Anthropology Quarterly, EarlyView.
Abstract In this article, I explore the connections between the medicalization of childbirth and environmental devastation through Guarani‐Mbyá understandings of life and the living. I argue that the cuts made to Guarani‐Mbyá women's vaginas (episiotomies) in Brazilian hospitals are experienced and situated on the same cosmopolitical level as the cuts ...
Maria Paula Prates
wiley   +1 more source

Community challenges in biomedical text mining over 10 years: success, failure and the future. [PDF]

Brief Bioinform, 2016
Huang CC, Lu Z.
europepmc   +1 more source

Computational analysis to assess hemodynamic forces in descending thoracic aortic aneurysms

The Journal of Physiology, EarlyView.
Abstract figure legend Left: Pre‐processing. First, we perform the segmentation of the Computer Tomography angiorgraphy (angio‐CT) scans of a healthy patient, obtaining the surface of a healthy thoracic aorta with a Type III aortic arch. Then, we build nine ideal configurations with Descending Thoracic Aortic Aneurysm (DTAA), varying the aortic arch ...
Francesca Duca, Daniele Bissacco, Luca Crugnola, Chiara Faitini, Maurizio Domanin, Francesco Migliavacca, Santi Trimarchi, Christian Vergara   +7 more
wiley   +1 more source

Vagus Nerve Stimulation Paired With Tones Alters the Auditory Cortex Proteome in a Rat Model of Rett Syndrome

Developmental Neurobiology, Volume 86, Issue 3, July 2026.
ABSTRACT Rett syndrome is a neurodevelopmental disorder caused by an X‐linked mutation of the MeCP2 gene. Individuals with Rett syndrome, as well as rodent models of this disorder, demonstrate abnormal cortical responses to sound, which impair auditory discrimination ability.
Isabella K. Myers, Fang Bian, Maria P. Solano, Yara El Zoghby, Diana Tavares‐Ferreira, Tanya Danaphongse, Crystal T. Engineer   +6 more
wiley   +1 more source