Results 161 to 170 of about 157,658 (286)

DysRegNet: Patient‐specific and confounder‐aware dysregulated network inference towards precision therapeutics

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Gene regulation is frequently altered in diseases in unique and patient‐specific ways. Hence, personalised strategies have been proposed to infer patient‐specific gene‐regulatory networks. However, existing methods do not scale well because they often require recomputing the entire network per sample.
Johannes Kersting, Olga Lazareva, Zakaria Louadi, Jan Baumbach, David B. Blumenthal, Markus List   +5 more
wiley   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11‐ßhydroxysteroid dehydrogenase type 1 (11‐ßHSD1) that regenerates active glucocorticoids from circulating metabolites.
Sara Al Disi, Raimondo Ascione, Shazia Khan, Thomas Johnson, Eva Sammut, Vito Domenico Bruno, Daniel Baz Lopez, Carol‐Anne James, Joanna Simpson, Natalie Z. Homer, Michael Millar, Trisha Singh, Alex von Kreigsheim, Nick L. Mills, Brian R. Walker, Ruth Andrew, Scott P. Webster, Andrew Whittaker, Adrian Freeman, Gillian A. Gray   +19 more
wiley   +1 more source

Associating protein residues in the literature with structural data. [PDF]

Acta Crystallogr D Struct Biol
A software tool is introduced for associating text mentions of protein residues with their respective residues in a protein structure, with display in a molecular viewer.Protein structures are crucial in understanding the function, mechanism and disease‐causing variants of proteins within any living cell.
Vollmar M, Westrip S, Nair S, Balasubramaniyan B, Velankar S, Jones L, Strickland P.   +6 more
europepmc   +2 more sources

Hypoxia regulates Th17/Treg balance by altering chromatin accessibility and gene expression

The FEBS Journal, EarlyView.
T‐cell differentiation into Th17 or iTreg cells is key to inflammation control. Integrated RNA‐seq and ATAC‐seq analyses reveal that hypoxia induces more extensive gene expression changes in iTreg cells. Elevated levels of Hif1a and Stat3, along with increased accessibility to key transcription factor motifs, may predispose these cells toward ...
Mariana Cázares‐Olivera, Shiyang Song, Sofia Ylinen, Talha Qureshi, Bin Li, Zhi Chen   +5 more
wiley   +1 more source

Fertility Governance Through Cascaded Accountability: Building Inclusive Safety Nets for Vulnerable Workers

Gender, Work &Organization, EarlyView.
ABSTRACT This article examines how workplace fertility governance operates as a system of control, consent, and inequality shaped by organizational, cultural, and institutional forces. Drawing on feminist theory, we develop a multilevel framework of cascading accountability that integrates symbolic violence, biopolitics, chrononormativity, and ...
Meltem Yavuz Serçekman, Mustafa F. Özbilgin   +1 more
wiley   +1 more source

Mining Biomedical Texts to Generate Semantic Annotations

, 2007
This report focuses on text mining in the biomedical domain for the generation of semantic annotations based on a formal model which is ontology. We start by exposing the generic methodology for the generation of annotations from texts. Then, we present a state of the art on different knowledge extraction techniques used on biomedical texts. We propose
Khelif, Khaled, Dieng-Kuntz, Rose, Barbry, Pascal   +2 more
openaire   +1 more source

Extracting vitalities: Cuts in Indigenous women's bodies‐territories (Brazil)

Medical Anthropology Quarterly, EarlyView.
Abstract In this article, I explore the connections between the medicalization of childbirth and environmental devastation through Guarani‐Mbyá understandings of life and the living. I argue that the cuts made to Guarani‐Mbyá women's vaginas (episiotomies) in Brazilian hospitals are experienced and situated on the same cosmopolitical level as the cuts ...
Maria Paula Prates
wiley   +1 more source

Introduction to BLAH5 special issue: recent progress on interoperability of biomedical text mining. [PDF]

Genomics Inform, 2019
Kim JD, Cohen KB, Collier N, Lu Z, Rinaldi F.   +4 more
europepmc   +1 more source

A Systematic Review on Applications of Artificial Intelligence for Obesity Prevention

Obesity Reviews, EarlyView.
ABSTRACT This systematic review examines the applications of artificial intelligence (AI) in preventing obesity, addressing a critical public health issue that affects a substantial portion of the population. With obesity rates rising alarmingly, particularly in the United States, this review synthesizes findings from 46 studies published between 2008 ...
Atefehsadat Haghighathoseini, Shuo‐yu Lin, Ge Song, Ruopeng An, Hong Xue   +4 more
wiley   +1 more source