Results 11 to 20 of about 421,156 (296)

Monoclonal antibodies for COVID-19 therapy and SARS-CoV-2 detection

Journal of Biomedical Science, 2022
The coronavirus disease 2019 (COVID-19) pandemic is an exceptional public health crisis that demands the timely creation of new therapeutics and viral detection.
Yu-Chyi Hwang, Ruei-Min Lu, Shih-Chieh Su, Pao-Yin Chiang, Shih-Han Ko, Feng-Yi Ke, Kang-Hao Liang, Tzung-Yang Hsieh, Han-Chung Wu   +8 more
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Bridging the gap between emerging models and humans by learning from polio animal studies: A systematic review

Clinical and Translational Discovery, 2022
Disease modelling plays a fundamental role in biomedical research, even more in virology where the virus depends strictly on its host for replication. Although animal models are extensively used in virology, there is an increasing demand for animal‐free ...
Giulia Moreni, Ikrame Aknouch, Morris Ras, Lieke Brouwer, René Spijker, Carlemi Calitz, Koert J. Stittelaar, Adithya Sridhar, Katja C. Wolthers, Dasja Pajkrt   +9 more
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Translating translation: Regulated protein translation as a biomedical intervention [PDF]

Fly, 2009
Altering the cellular response to internal and external stressors is essential for survival, hence the process of translation is exquisitely regulated to rapidly change the proteomic profile upon physiological challenges. We recently reported that genetic and pharmacological manipulation of translation may be beneficial in the treatment of Parkinson ...
Luke S, Tain, Alexander J, Whitworth
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Orally administered branaplam does not impact neurogenesis in juvenile mice, rats, and dogs

Biology Open, 2021
Branaplam is a therapeutic agent currently in clinical development for the treatment of infants with type 1 spinal muscular atrophy (SMA). Since preclinical studies showed that branaplam had cell-cycle arrest effects, we sought to determine whether ...
Diethilde Theil, Reginald Valdez, Katy Darribat, Arno Doelemeyer, Rajeev Sivasankaran, Andreas Hartmann   +5 more
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Toward A Universal Biomedical Data Translator [PDF]

Clinical and Translational Science, 2018
Myriad biomedical data are available today and bring with them a need to "translate" those data into meaningful information that can be used to accelerate clinical and translational science and drive innovations in clinical care and drug discovery. We describe the work of The Biomedical Data Translator Consortium to develop a platform that supports the
Fecho, Karamarie, Ahalt, Stanley C., Altman, Russ B., Balhoff, Jim, Bizon, Chris, Brukiewich, Richard, Burtt, Noel, Chute, Christopher G., Clemons, Paul A., Cox, Steve, Dancik, Vlado, Dumontier, Michel, Glusman, Gustavo, Guha, Rajarshi, Haendel, Melissa, Ideker, Trey, Mungall, Christopher, Peden, David B., Su, Andrew, Tatonetti, Nicholas, Tropsha, Alexander, Weng, Chunhua, Yu, Michael   +22 more
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Monoclonal antibodies against S2 subunit of spike protein exhibit broad reactivity toward SARS-CoV-2 variants

Journal of Biomedical Science, 2022
Background The variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) harbor diverse spike (S) protein sequences, which can greatly influence the efficacies of therapeutics.
Shih-Han Ko, Wan-Yu Chen, Shih-Chieh Su, Hsiu-Ting Lin, Feng-Yi Ke, Kang-Hao Liang, Fu-Fei Hsu, Monika Kumari, Chi-Yu Fu, Han-Chung Wu   +9 more
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Optimization and Improvement of qPCR Detection Sensitivity of SARS-CoV-2 in Saliva

Microbiology Spectrum, 2023
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a major public health threat globally, especially during the beginning of the pandemic in 2020.
Hui-Ying Ko, Yao-Tsun Li, Ya-Yuan Li, Ming-Tsai Chiang, Yi-Ling Lee, Wen-Chun Liu, Chun-Che Liao, Chih-Shin Chang, Yi-Ling Lin   +8 more
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Understanding the role of APOE Gene Polymorphisms in Minimal Atrophy Alzheimer’s Disease by mixture of expert models [PDF]

E3S Web of Conferences, 2021
Alzheimer’s disease (AD) is a heterogeneous disease. Exploring the characteristics of each AD subtype is the key to disentangling the heterogeneity. Minimal atrophy AD (MAD) is a common AD subtype that yields conflicting results.
Lin Lan, Zhang Ge, Zhang Baiwen, Wu Shuicai   +3 more
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Progress toward a universal biomedical data translator

Clinical and Translational Science, 2022
AbstractClinical, biomedical, and translational science has reached an inflection point in the breadth and diversity of available data and the potential impact of such data to improve human health and well‐being. However, the data are often siloed, disorganized, and not broadly accessible due to discipline‐specific differences in terminology and ...
Fecho, Karamarie, Thessen, Anne E., Baranzini, Sergio E., Bizon, Chris, Hadlock, Jennifer J., Huang, Sui, Roper, Ryan T., Southall, Noel, Ta, Casey, Watkins, Paul B., Williams, Mark D., Xu, Hao, Byrd, William, Dančík, Vlado, Duby, Marc P., Dumontier, Michel, Glusman, Gustavo, Harris, Nomi L., Hinderer, Eugene W., Hyde, Greg, Johs, Adam, Su, Andrew I., Qin, Guangrong, Zhu, Qian, Dougherty, Jennifer, Huang, Conrad, Magis, Andrew, Smith, Brett, Celebi, Remzi, Chen, Zhehuan, Azevedo, Ricardo De Miranda, Emonet, Vincent, Lee, Jay, Weng, Chunhua, Yilmaz, Arif, Kim, Keum Joo, Santos, Eugene, Tonstad, Lucas, Veenhuis, Luke, Yakaboski, Chase, Acevedo, Liliana, Carrell, Steven, Deutsch, Eric, Glen, Amy, Hoffman, Andrew, Koslicki, David, Kvarfordt, Lindsey, Liu, Zheng, Liu, Shaopeng, Ma, Chunyu, Mendoza, Luis, Muluka, Arun Teja, Womack, Finn, Wood, Erica, Roach, Jared, Goel, Prateek, Weber, Rosina, Williams, Andrew, Gormley, Joseph, Zisk, Tom, Hanspers, Kristina, Hoatlin, Maureen, Pico, Alexander, Riutta, Anders, Callaghan, Jackson, Xu, Colleen, Ahalt, Stanley C., Balhoff, Jim, Edwards, Stephen, Haaland, Perry, Knowles, Michael, Krishnamurthy, Ashok, Mandal, Meisha, Peden, David B., Pfaff, Emily, Schurman, Shepherd, Shrivastava, Shalki, Yi, Hong, Reilly, Jason, Kanwar, Richa, Cox, Steven, Vaidya, Gaurav, Wang, Max, Alkanaq, Ahmed, Costanzo, Maria, Koesterer, Ryan, Flannick, Jason, Burtt, Noel, Kluge, Alexandria, Rubin, Irit, Strasser, Michael “ Michi”, Chung, Lawrence, Kang, Jimin, Mantilla, Michelle, Muller, Sandrine, Persaud, Bria, Wei, Qi, Baumgartner, Andrew, Dai, Cheng, Duvvuri, Venkata, Mauldin, Denise, Shmulevich, Ilya, Brandon, Namdi, Greyber, Alon, Kebede, Yaphet, Korn, Daniel, Mesbah, Abrar, Owen, Phil, Sakaguchi, Rayn, Seitanakis, Sarah, Tropsha, Alexander, Viola, Adam, Hubal, Robert, Mersmann, Marian, Morton, Kenny, Yao, Yao, Lin, Jason, Avila, Ricardo, Wu, Chunlei, Cano, Marco Alvarado, Gardner, Vicki, Issabekova, Tursynay, McMurry, Julie, Schaper, Kevin, Baumgartner, William, Cohen, Kevin, Gatica, Edgar, Hunter, Lawrence, Price, Guthrie, He, Kaiwen, Henrickson, Jeff, Mamidi, Tarun, Might, Matthew, Osborne, John, Patton, Michael, Rosenblatt, Greg, Tran‐Nguyen, Thi, Crouse, Andrew, Belhu, Basazin, Conlin, Tom, Huellas‐Bruskiewicz, Kenneth, Rudavsky‐Brody, Nathaniel, Shrestha, Manil, Stillwell, Lisa, von Grotthuss, Marcin, Wang, Patrick, Xin, Jiwen Kevin, Zhou, Xinghua, Champion, James, Scott, Erik, Sharma, Priya, Sinha, Meghamala, Raj, Shruti, Mease, Philip, Peene, R. Carter, McClelland, Jason, Schmitt, Charles P., Leigh, Margaret, Corkill, Dan, Zhou, Eric, Alden, John, Massung, Jeffrey, Brandes, Mac Kenzie, Amin, Nada, Chen, Mei‐Jan, Crowder, Camerron, Crumbley, Mary E., Fehrmann, Nathaniel, Foksinska, Aleksandra M., Jenkins, Lindsay, He, Kaiwen, Huls, Forest B., Jarrell, Matthew, Pollard, Elizabeth, Rucka, Sienna, Southern, Nicholas, Tinglin, Jillian, Whitlock, Jordan, Zheng, Marissa   +178 more
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Switching from blonanserin tablets to blonanserin transdermal patches improves tardive dyskinesia: A case report

Neuropsychopharmacology Reports, 2021
Tardive dyskinesia (TD) is a common side effect of antipsychotics, and it remains a persistent and challenging problem. The blonanserin transdermal patch, developed in Japan and launched in September 2019, is the first antipsychotic transdermal treatment.
Shintaro Sakai, Yoshiro Morimoto, Yusuke Matsuzaka, Takeshi Nakano, Shinji Kanegae, Akira Imamura, Hiroki Ozawa   +6 more
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