Results 71 to 80 of about 418,008 (279)

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

The RNA Ontology (RNAO): An ontology for integrating RNA sequence and structure data [PDF]

, 2009
Biomedical Ontologies are intended to integrate diverse biomedical data to enable intelligent data-mining and facilitate translation of basic research into useful clinical knowledge.
Chris Mungall, Colin Batchelor, Craig Zirbel, Eric Westhof, Jane Richardson, Jesse Stombaugh, Karen Eilbeck, Neocles Leontis, Rob Knight, Thomas Bittner   +9 more
core   +1 more source

Anthropology, Brokerage and Collaboration in the development of a Tongan Public Psychiatry: Local Lessons for Global Mental Health [PDF]

, 2016
The Global Mental Health (GMH) movement has revitalised questions of the translatability of psychiatric concepts and the challenges of community engagement in countries where knowledge of the biomedical basis for psychiatric diagnosis is limited or ...
Campbell I. C., Churchward C. M., Cowling W. E., Desjarlais R., Fadgen T. P., Gordon T., Heaton M. M., Helu F., Janman P., Jilek W. G., Jilek W. G., Latukefu S., Leckie J., Littlewood R., Luhrmann T., Mike Poltorak, Minister of Health, Moala K., Morton H., Parsons C. D. F., Puloka M. H., Puloka M. H., Puloka M. H., Shore B., Thaman K. H., Vaiola Hospital Psychiatric Unit, Vaiola Hospital Psychiatric Unit, Vaiola Hospital Psychiatric Unit, Vaka S. L., Weiss P., Williams A. T., Williams A. T., World Health Organization (WHO), ‘Atenisi University   +33 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Indiana Consortium for Innovation in Biomedical Imaging [PDF]

, 2016
poster abstractThe Indiana Consortium for Innovation in Biomedical Imaging (Indiana-CIBI) has been established to leverage the biomedical imaging strengths of several major academic institutions throughout Indiana.
Holland, Mark R., Hutchins, Gary D.
core  

A novel closed-chest porcine model of chronic ischemic heart failure suitable for experimental research in cardiovascular disease [PDF]

, 2013
Cardiac pathologies are among the leading causes of mortality and morbidity in industrialized countries, with myocardial infarction (MI) representing one of the major conditions leading to heart failure (HF).
Antonio Amodeo, BIONDI ZOCCAI, GIUSEPPE, CALOGERO, ANTONELLA, CAVARRETTA, Elena, CHIMENTI, ISOTTA, DE FALCO, ELENA, Fabrizio D'Ascenzo, FRATI, GIACOMO, Luca Pacini, MANCONE, Massimo, Maria Emiliana Caristo, MARULLO, Antonino, Marzia Lotrionte, Omar Leoni, PERUZZI, MARIANGELA, PETROZZA, Vincenzo   +15 more
core   +3 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Preserving spatial and quantitative information in unpaired biomedical image-to-image translation

Cell Reports: Methods
Summary: Analysis of biological samples often requires integrating diverse imaging modalities to gain a comprehensive understanding. While supervised biomedical image translation methods have shown success in synthesizing images across different ...
Joshua Yedam You, Minho Eom, Tae-Ik Choi, Eun-Seo Cho, Jieun Choi, Minyoung Lee, Changyeop Shin, Jieun Moon, Eunji Kim, Pilhan Kim, Cheol-Hee Kim, Young-Gyu Yoon   +11 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Adverse effects of total hip arthroplasty on the hip abductor and adductor muscle lengths and moment arms during gait

Journal of Orthopaedic Surgery and Research, 2020
Background Precise evaluation of the hip abductor and adductor muscles function in total hip arthroplasty (THA) patients during gait could help prevent postoperative complications and optimize the rehabilitation training program.
Xiangjun Hu, Nan Zheng, Wei-Chun Hsu, Jingwei Zhang, Huiwu Li, Yunsu Chen, Kerong Dai, Tsung-Yuan Tsai   +7 more
doaj   +1 more source