Results 41 to 50 of about 72,976 (216)
Advanced Science, EarlyView.This study shows that a local, data‐driven AI model can accurately predict diverse optical and chiroptical properties of [6]helicenes using information from close structural neighbours. Combined with genetic algorithms, it enables inverse design for tailored properties, establishing practical structure–property rules for efficient molecular discovery ...
Rafael G. Uceda +8 more
wiley +1 more source
Curcumin ameliorates autoimmune diabetes. Evidences in accelerated murine models of type 1 diabetes [PDF]
, 2014 Type 1 diabetes (T1DM) is a T cell-mediated autoimmune disease that selectively destroys pancreatic β cells. The only possible cure for T1DM is to control autoimmunity against β cell-specific antigens.
Antunica Noguerol, María de Las Nieves +8 more
core +1 more source
American Journal of Hematology, EarlyView.ABSTRACT The addition of midostaurin (MIDO) to intensive chemotherapy (IC) improves survival in younger adults with FLT3‐mutated acute myeloid leukemia (AML); however, real‐world data in elderly patients (≥ 60 years) are limited. This large, retrospective, multicenter study from three European registries (PETHEMA, FILO, DATAML) evaluated MIDO+IC (n ...
Gaspar Aspas Requena +31 more
wiley +1 more source
The effect of experience and of dots\u2019 density and duration on the detection of coherent motion in dogs [PDF]
, 2018 Knowledge about the mechanisms underlying canine vision is far from being exhaustive, especially that concerning post- retinal elaboration. One aspect that has received little attention is motion perception, and in spite of the common belief that dogs ...
Battaglini, Luca +5 more
core +1 more source
Epilepsia Open, EarlyView.Abstract Objective Sialidosis type I (ST‐1) is an autosomal‐recessive, very rare, progressive lysosomal storage disorder caused by pathogenic variants in NEU1. It is clinically characterized by progressive ataxia, myoclonic seizures (MS), bilateral tonic–clonic seizures (BTCS), and distinctive ophthalmological findings.
Janina Gburek‐Augustat +15 more
wiley +1 more source
REVISTA PRAXIS, 2018 Este artículo muestra que la justifcación del enfoque médico dominante, de que su actividad es científca porque parte de la evidencia de las pruebas, en muchos casos observacionales, es un acto de fe, que resulta completamente anacrónico en comparación con los debates científcos contemporáneos.
openaire +2 more sources
The cargo protein MAP17 (PDZK1IP1) regulates the cancer stem cell pool activating the Notch pathway by abducting NUMB [PDF]
, 2017 Purpose: Cancer stem cells (CSC) are self-renewing tumor cells, with the ability to generate diverse differentiated tumor cell subpopulations. They differ from normal stem cells in the deregulation of the mechanisms that normally control stem cell ...
Carnero Moya, Amancio +4 more
core +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Toxicological assessment is essential in NP approval for health and medical applications. Although 2D cell culture has been widely used, 3D models, especially spheroids, provide better predictive value for toxicological risk assessments since they replicate complex cellular interactions more accurately.
Bianca Montenegro +5 more
wiley +1 more source
A synthetic biology approach for consistent production of plant-made recombinant polyclonal antibodies against snake venom toxins [PDF]
, 2018 Antivenoms developed from the plasma of hyperimmunized animals are the only effective treatment available against snakebite envenomation but shortage of supply contributes to the high morbidity and mortality toll of this tropical disease.
Arnold +38 more
core +2 more sources
Complementary and Integrative Medicine for the Treatment of Tourette's Syndrome
Movement Disorders Clinical Practice, EarlyView.Abstract Background There is widespread interest in complementary and integrative medicine (CIM) among people with Tourette's syndrome (TS). Objective To perform a systematic review of evidence on the use of CIM to reduce tics and improve tic‐related quality of life.
Tamara Pringsheim +21 more
wiley +1 more source