Results 11 to 20 of about 3,762 (133)

Vitamin D Supplementation and Mortality in the Elderly: A Review of a Meta-Analysis of Randomized Controlled Trials Using the REB Method. [PDF]

Fundam Clin Pharmacol
ABSTRACT Background The results of randomized controlled trials (RCTs) regarding the effect of vitamin D supplementation on mortality reduction are conflicting. Objective The aim of this study was to assess the level of evidence through a sensitivity analysis of the meta‐analysis by Shah et al.
Kostakis N, Lega JC, Boussageon R.
europepmc   +2 more sources

Redefining Regulatory Proof: The End of the Two-Trial Paradigm. [PDF]

Fundam Clin Pharmacol
ABSTRACT The recent decision to establish a single pivotal trial as the default evidentiary standard for Food and Drug Administration (FDA) approval marks a substantive shift in the architecture of regulatory proof. This marks a shift from replication‐based validation to a coherence‐based model of sufficiency, beyond a procedural adjustment.
Lega JC, Provencher S, Falissard B, Locher C, Roustit M, Gougeon A, Boussageon R, Chevret S.   +7 more
europepmc   +2 more sources

From Inference to Ritual: Why Frequentist Statistics Became Hard to Understand and Teach in Medicine. [PDF]

J Eval Clin Pract
ABSTRACT Introduction Frequentist statistical tools still structure a large part of biomedical research, regulatory evaluation, and medical teaching, even though their correct interpretation remains uncertain among students, clinicians, and readers of the literature.
Lega JC, Chevret S.
europepmc   +2 more sources

Validating the 2022 WHO classification in thyroid carcinomas: Prospective evidence for predicting iodine resistance. [PDF]

Histopathology
This study assessed the 2022 WHO classification for predicting RAIR disease in thyroid carcinomas, comparing it to older classifications. In a retrospective study of 253 cases, we found the 2022 classification more effective, especially by identifying high‐grade carcinomas and tumour necrosis as critical predictive factors.
André E, Mebarki L, Ilie M, Subtil F, Bournaud C, Borson-Chazot F, Descotes F, Lifante JC, Bertholon-Grégoire M, Lasolle H, Decaussin-Petrucci M.   +10 more
europepmc   +2 more sources

Buchbesprechungen

Austrian Journal of Statistics, 2016
Mathematische Statistik II. (H. Witting, U. Müller-Funk) Schließende Statistik. (W. Polasek) The New Statistical Analysis of Data. (T.W. Anderson, J.D. Finn) Grundbegriffe der Biometrie. (R.J. Lorenz) Vorlesungen über Wahrscheinlichkeitstheorie.
Johann Pfanzagl, Andreas Quatember, Bernhard Böhm, Ulrike Leopold-Wildburger, Norbert Kusolitsch, Christine Duller, Walter Katzenbeisser, Karl Schableger, Rudolf Dutter   +8 more
doaj   +1 more source

Latent class distributional regression for the estimation of non-linear reference limits from contaminated data sources

BMC Bioinformatics, 2020
Background Medical decision making based on quantitative test results depends on reliable reference intervals, which represent the range of physiological test results in a healthy population.
Tobias Hepp, Jakob Zierk, Manfred Rauh, Markus Metzler, Andreas Mayr   +4 more
doaj   +1 more source

Assessment of Imputation Quality: Comparison of Phasing and Imputation Algorithms in Real Data

Frontiers in Genetics, 2021
Despite the widespread use of genotype imputation tools and the availability of different approaches, late developments of currently used programs have not been compared comprehensively. We therefore assessed the performance of 35 combinations of phasing
Katharina Stahl, Katharina Stahl, Damian Gola, Inke R. König, Inke R. König   +4 more
doaj   +1 more source

Biostatistik/Biometrie für Mediziner/-innen – unabdingbar oder entbehrlich? Wie bewerten praktizierende Human- und Zahnmediziner/-innen die Biostatistik/Biometrie? Eine Fragebogenstudie

GMS Medizinische Informatik, Biometrie und Epidemiologie, 2023
Background: The aim of this project was to explore how physicians and dentists in Germany evaluate biostatistics/biometry in general as well as their training in it.
Hartmann, Nina Alida, Vens, Maren, König, Inke Regina   +2 more
doaj   +1 more source

Pre- Versus Post-Breeding Population Projection Models? A Simple Fix to a Common Parametrization Error. [PDF]

Ecol Evol
Population Projection Models (PPMs) are essential tools in demographic studies for predicting the growth of structured populations. This work introduces a simple, robust method for constructing pre‐ and post‐breeding projection matrices called MAP for Matrices Alternated Products directly from empirical data, addressing common errors related to ...
Martin TLP, Gaillard JM, Bonenfant C.
europepmc   +2 more sources

Freier Zugang zu Dokumentationsformularen und Merkmalskatalogen im Gesundheitswesen. Memorandum „Open Metadata“

GMS Medizinische Informatik, Biometrie und Epidemiologie, 2014
[english] Currently, most of the documentation forms and item catalogs in healthcare are not accessible to the public. This applies both to clinical information systems and case report forms (CRFs) from studies. Open access to medical documentation forms
Dugas, Martin, Jöckel, Karl-Heinz, Gefeller, Olaf, Knaup-Gregori, Petra, Friede, Tim, Ammenwerth, Elske, Kieser, Meinhard, Prokosch, Hans-Ulrich   +7 more
doaj   +1 more source