Results 51 to 60 of about 83,797 (319)

Measuring the energy landscape roughness and the transition state location of biomolecules using single molecule mechanical unfolding experiments

, 2006
Single molecule mechanical unfolding experiments are beginning to provide profiles of the complex energy landscape of biomolecules. In order to obtain reliable estimates of the energy landscape characteristics it is necessary to combine the experimental ...
Changbong Hyeon, D Thirumalai, Derenyi I, Evans E, Fisher T E, Hummer G, Lide D R, Lu H, Ritort F, Zwanzig R   +9 more
core   +1 more source

Applying forces to elastic network models of large biomolecules using a haptic feedback device [PDF]

, 2011
Elastic network models of biomolecules have proved to be relatively good at predicting global conformational changes particularly in large systems. Software that facilitates rapid and intuitive exploration of conformational change in elastic network ...
Hayward, Steven, Laycock, Stephen, Stocks, Matthew   +2 more
core   +1 more source

Biomolecule screen identifies several inhibitors of Salmonella enterica surface colonization

Frontiers in Bioengineering and Biotechnology
Salmonella enterica is a foodborne pathogen commonly found in agricultural facilities; its prevalence, as well as increasing levels of disinfectant- and antibiotic-resistance, has significant costs for agriculture as well as human health. In an effort to
Joseph Headrick, Amital Ohayon, Shannon Elliott, Jacob Schultz, Erez Mills, Erik Petersen   +5 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Refolding dynamics of stretched biopolymers upon force quench

, 2009
Single molecule force spectroscopy methods can be used to generate folding trajectories of biopolymers from arbitrary regions of the folding landscape.
Bell, C. Hyeon, Camacho, Camacho, Cecconi, Chandrasekhar, D. L. Pincus, D. Thirumalai, Dill, Dudko, Fernandez, Fu, G. Morrison, Hyeon, Klimov, Onuchic, Sali, Shakhnovich   +17 more
core   +2 more sources

Collective behavior of oscillating electric dipoles [PDF]

, 2017
The present work reports about the dynamics of a collection of randomly distributed, and randomly oriented, oscillators in 3D space, coupled by an interaction potential falling as $1/r^3$, where r stands for the inter-particle distance.
Donato, Irene, Gori, Matteo, Olmi, Simona, Pettini, Marco   +3 more
core   +4 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Biomolecule surface patterning may enhance membrane association

, 2012
Under dehydration conditions, amphipathic Late Embryogenesis Abundant (LEA) proteins fold spontaneously from a random conformation into alpha-helical structures and this transition is promoted by the presence of membranes.
Browne J., Garay-Arroyo A., Gkeka P., Goyal K., Illya G., Nigel K. H. Slater, Panchal R. G., Pogodin S., Pogodin S., Pogodin S., Pogodin S., Popova A. V., Sergey Pogodin, Tolleter D., Tunnacliffe A., Vladimir A. Baulin, Wise M. J., Yang L.   +17 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Bioadditive manufacturing of hybrid tissue scaffolds for controlled release kinetics [PDF]

, 2012
Development of engineered tissue scaffolds with superior control over cell-protein interactions is still very much infancy. Advancing through heterogeneous multifold scaffolds with controlled release fashion enables synchronization of regenerating tissue
Khoda, AKMB, Koç, Bahattin, Özbolat, İbrahim T.   +2 more
core   +1 more source