Results 301 to 310 of about 98,962 (385)

Modeling of Disease Progression of Type 2 Diabetes Using Real‐World Data: Quantifying Competing Risks of Morbidity and Mortality

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 606-615, March 2025.
ABSTRACT Type 2 diabetes (T2D) is a progressive metabolic disorder that could be an underlying cause of long‐term complications that increase mortality. The assessment of the probability of such events could be essential for mortality risk management. This work aimed to establish a framework for risk predictions of macrovascular complications (MVC) and
Hanna Kunina, Stefan Franzén, Maria C. Kjellsson   +2 more
wiley   +1 more source

Paliperidone Acid-Based Cocrystal for Improving Biopharmaceutical Properties: In Vitro and In Vivo Evaluation. [PDF]

ACS Omega
Elmowafy M, Alruwaili NK, Alsaidan OA, Elkomy MH, Abdelgawad MA, Ibrahim MF, Zidan MF, Elbahwy IA, Barakat EH.   +8 more
europepmc   +1 more source

Membrane Separation and Purification in Production Process of Blood–derived Products and Biopharmaceuticals

, 2009
Takao Nishimura
openalex   +2 more sources

A Combined Modeling Approach to Predict the Effect of Gastric Emptying Delay on the Pharmacokinetics of Small Molecules

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Dulaglutide, a long‐acting glucagon‐like peptide‐1 (GLP‐1) receptor agonist, is approved for improving glycemic control and reducing cardiovascular risks in patients with type 2 diabetes mellitus (T2DM). This research investigates the effect of dulaglutide on gastric emptying and its impact on the pharmacokinetics (PK) of orally administered ...
Maria M. Posada, Karen B. Schneck, Bridget L. Morse, Luc R. A. Rougee, Lai San Tham, Jessica F. Rehmel, Brian Thompson, Stephen D. Stamatis, Stephen D. Hall, Gemma L. Dickinson   +9 more
wiley   +1 more source

Synthetic G-quadruplex components for predictable, precise two-level control of mammalian recombinant protein expression. [PDF]

Nucleic Acids Res
Pohle M, Curry E, Holden R, Gibson S, Brown A.   +4 more
europepmc   +1 more source

An Open‐Source Framework for Virtual Bioequivalence Modeling and Clinical Trial Design

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT To establish bioequivalence (BE) of a generic test formulation with respect to a reference listed drug, it is necessary to demonstrate a comparable rate and extent to which active ingredients reach the site of action. To decrease unnecessary human testing and simulate scenarios involving specific populations or challenges with recruitment or ...
Abdullah Hamadeh, Moriah Pellowe, Pierre Chelle, Cindy Hoi Ting Yeung, Julian Otalvaro, Walter Yamada, Jay Bartroff, Alona Kryshchenko, André Dallmann, Juri Solodenko, Jörg Lippert, Eleftheria Tsakalozou, Michael Neely, Andrea Edginton   +13 more
wiley   +1 more source

Elevating MHC I expression on tumor cells by nanovesicles loading tyrosine kinase inhibitors can improve the efficacy of cancer vaccines. [PDF]

Front Immunol
Xie H, Ma L, He X, Zhao S, Wang J, Zhu A, Liu C, Piskareva O, Deng C, Meng F, Liu M.   +10 more
europepmc   +1 more source

The Evolving Role of In Vitro–In Vivo Correlation in Model‐Informed Drug Development: A Multi‐Stakeholder Perspective

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT In vitro–in vivo correlation/relationship (IVIVC/R) models such as physiologically based biopharmaceutics modeling (PBBM) are crucial tools that link biopharmaceutical properties to clinical performance. They accelerate development, reduce costly experimental studies and clinical trials, and justify regulatory decisions for drug formulation ...
Marylore Chenel, Sylvain Fouliard, Emma Hansson, Karl Brendel, Matthieu Jacobs, Hans Lennernäs, Erik Sjögren, Martin Bergstrand   +7 more
wiley   +1 more source

Author Correction: Neutrophil extracellular traps mediate the crosstalk between plaque microenvironment and unstable carotid plaque formation. [PDF]

Exp Mol Med
Cao Y, Chen M, Jiao X, Li S, Wang D, Zhan Y, Li J, Hao Z, Li Q, Liu Y, Feng Y, Li R, Wang H, Liu M, Fu Q, Li Y.   +15 more
europepmc   +1 more source

Jujuboside B Induces Ferroptosis and Overcomes Radioresistance Through the PPARγ‐ATF3‐Gpx4 Signaling Pathway in Non‐Small Cell Lung Cancer

Phytotherapy Research, EarlyView.
Jujuboside B induces ferroptosis and overcomes radioresistance. ABSTRACT Jujuboside B (JJB) is a saponin extracted from the Ziziphus jujuba var. spinose and has been reported to have anticancer effects. However, the detailed mechanism of its anti‐cancer effect in non‐small cell lung cancer (NSCLC) remains unclear.
Tae Woo Kim, Seong‐Gyu Ko
wiley   +1 more source