Results 301 to 310 of about 101,810 (380)

Power priors for latent variable mediation models under small sample sizes

British Journal of Mathematical and Statistical Psychology, EarlyView.
Abstract Latent variable models typically require large sample sizes for acceptable efficiency and reliable convergence. Appropriate informative priors are often required for gainfully employing Bayesian analysis with small samples. Power priors are informative priors built on historical data, weighted to account for non‐exchangeability with the ...
Lihan Chen, Milica Miočević, Carl F. Falk   +2 more
wiley   +1 more source

Correction: Metastatic sites of baseline as predictors in recurrent or metastatic nasopharyngeal carinoma treated with PD-L1 inhibitor: a secondary analysis of multicenter, single-arm, phase II study (KL-A167). [PDF]

Cancer Immunol Immunother
Li Y, Min Y, Wei Z, Liu Z, Pei Y, Yang Y, Gao K, Song G, Xu S, He S, Ge J, Qing Y, Wei Y, Ai P, Chen Y, Peng X.   +15 more
europepmc   +1 more source

Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1

British Journal of Pharmacology, EarlyView.
Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim, Junhyuk Woo, Sungmin Pak, Joonho Paik, Gyu‐Sang Hong, Ji Hun Wi, Sanghee Lee, Cristina Fenollar‐Ferrer, Kyungreem Han, Young Kee Shin, Uhtaek Oh   +10 more
wiley   +1 more source

Physiologically Based Pharmacokinetic Modeling of Efavirenz Nanoparticles: from Animal Model to Human Extrapolation. [PDF]

ACS Omega
da Silva TM, Sarcinelli MA, Cunha Chaves MH, Dias AA, Patricio BFC, Prado LD, Tasso L, Duque MD, Rocha HVA.   +8 more
europepmc   +1 more source

Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11‐ßhydroxysteroid dehydrogenase type 1 (11‐ßHSD1) that regenerates active glucocorticoids from circulating metabolites.
Sara Al Disi, Raimondo Ascione, Shazia Khan, Thomas Johnson, Eva Sammut, Vito Domenico Bruno, Daniel Baz Lopez, Carol‐Anne James, Joanna Simpson, Natalie Z. Homer, Michael Millar, Trisha Singh, Alex von Kreigsheim, Nick L. Mills, Brian R. Walker, Ruth Andrew, Scott P. Webster, Andrew Whittaker, Adrian Freeman, Gillian A. Gray   +19 more
wiley   +1 more source

Correction: Association of lymphocyte subsets percentage with prognosis for recurrent or metastatic nasopharyngeal carcinoma patients receiving PD-L1 inhibitors. [PDF]

Cancer Immunol Immunother
Diao J, Wei Z, Pei Y, Ge J, Qing Y, Wei Y, Chen Y, Peng X.   +7 more
europepmc   +1 more source

Protectin D1 and maresin 1 attenuate airway hyperreactivity induced by IL‐13 in human isolated small bronchi

British Journal of Pharmacology, EarlyView.
Background and Purpose Interleukin (IL)‐13 is implicated in airway hyperreactivity (AHR), a key feature of asthma. We explored the potential anti‐AHR activity of selected specialised pro‐resolving mediators (SPMs) in IL‐13‐induced AHR models, using human bronchial smooth muscle cells (BSMCs) and human isolated bronchi.
Willem Abma, Sven‐Erik Dahlén, Craig E. Wheelock, Mikael Adner, Mamdoh Al‐Amerie, Erik Sachs, Kasra Vali Jalali, Leonardo De Maria, Henric Olsson, Jesper Säfholm   +9 more
wiley   +1 more source

Safety, tolerability and immunogenicity of a quadrivalent recombinant norovirus vaccine (Pichia pastoris) in participants six weeks of age or older: Phase I/IIa trial. [PDF]

Emerg Microbes Infect
Chen G, Shi L, Yu Q, Liu Q, Wang X, Liu Y, Ding F, Yuan L, Wang P, Zhou X, Zhang Y, Huang Z, Li J, Hu Z, Huang T.   +14 more
europepmc   +1 more source

Profiling of HCAR1 signalling reveals Gαi/o and Gαs activation without β‐arrestin recruitment and the discovery of an allosteric agonist

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lactate, historically viewed as a metabolic by‐product, has emerged as a signalling molecule via the G protein–coupled receptor Hydroxycarboxylic Acid Receptor 1 (HCAR1). The receptor is primarily expressed in adipocytes but also found in various other tissues.
Simon Lind, Shane C. Wright, Emilia Gvozdenovic, Kristina Nilsson, Kenneth L. Granberg, Michel Bouvier, Linda C. Johansson   +6 more
wiley   +1 more source

LiCl-driven direct synthesis of mono-protected esters from long-chain dicarboxylic fatty acids. [PDF]

RSC Adv
Kuang Y, Yang X, Qin T, Wang J, Guo P, Jiang C.   +5 more
europepmc   +1 more source