Results 351 to 360 of about 98,962 (385)
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2013
This chapter provides a high-level overview of the development of biopharmaceuticals from a toxicologic pathology perspective. Unlike their small molecule counterparts, biomolecules have well-defined physicochemical attributes, and often much more specific pharmacology.
Wendy G. Halpern, David Hutto
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This chapter provides a high-level overview of the development of biopharmaceuticals from a toxicologic pathology perspective. Unlike their small molecule counterparts, biomolecules have well-defined physicochemical attributes, and often much more specific pharmacology.
Wendy G. Halpern, David Hutto
openaire +4 more sources
Current Opinion in Biotechnology, 2000
The rapid maturation of the field of biopharmaceutical formulation is the result of the simultaneous development of a thermodynamic mechanism for protein-solvent interaction and identification of natural chemicals employed by nature to stabilize proteins in response to environmental stresses.
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The rapid maturation of the field of biopharmaceutical formulation is the result of the simultaneous development of a thermodynamic mechanism for protein-solvent interaction and identification of natural chemicals employed by nature to stabilize proteins in response to environmental stresses.
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Quality by design for biopharmaceuticals
Nature Biotechnology, 2009The US Food and Drug Administration's 'quality by design' approach is likely to transform the manufacture of biologics.
Helen Winkle, Anurag S. Rathore
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Application of microphysiological systems in biopharmaceutical research and development.
Lab on a Chip, 2020Within the last 10 years, several tissue microphysiological systems (MPS) have been developed and characterized for retention of morphologic characteristics and specific gene/protein expression profiles from their natural in vivo state.
N. Peterson +3 more
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A review of methods for solubility determination in biopharmaceutical drug characterization
Drug Development and Industrial Pharmacy, 2019The significance of thermodynamic solubility in biopharmaceutical compound or drug characterization as well as the importance of having methods that accurately establish it have been extensively addressed. Nonetheless, its precise determination continues
A. Veseli, S. Žakelj, A. Kristl
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Bioequivalence and the immunogenicity of biopharmaceuticals
Nature Reviews Drug Discovery, 2002The expiry of the first patents for recombinant-DNA-derived biopharmaceuticals will open the possibility of marketing generics, if they can be shown to be essentially similar to the innovator product. However, as shown by the problem of immunogenicity, the properties of biopharmaceuticals are dependent on many factors, including downstream processing ...
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Chondroitin Sulfate: Emerging biomaterial for biopharmaceutical purpose and tissue engineering.
Carbohydrate Polymers, 2022Reena Sharma +6 more
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Biotechnology and Biopharmaceutical Manufacturing, Processing, and Preservation
, 2020Chapters cover: o Large-Scale Freezing & Thawing of Biopharmaceutical Products, R. Wisniewski & V. Wu o Process Design for Large-Scale Chromatography of Biomolecules, R. Wisniewski, E. Boschetti, & A. Jungbauer o Lyophilization of Protein Pharmaceuticals,
K. Avis, Vincent L. Wu
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Artificial intelligence and machine learning applications in biopharmaceutical manufacturing.
Trends in Biotechnology, 2022A. Rathore +3 more
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Lab on a Chip, 2019
The lung is a complex organ; it is both the initial barrier for inhaled agents and the site of metabolism and therapeutic effect for a subset of systemically administered drugs.
G. Ainslie +7 more
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The lung is a complex organ; it is both the initial barrier for inhaled agents and the site of metabolism and therapeutic effect for a subset of systemically administered drugs.
G. Ainslie +7 more
semanticscholar +1 more source