Results 31 to 40 of about 70,680 (286)
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source
Harnessing Macrophages for Controlled-Release Drug Delivery: Lessons From Microbes
Frontiers in Pharmacology, 2019 With the effectiveness of therapeutic agents ever decreasing and the increased incidence of multi-drug resistant pathogens, there is a clear need for administration of more potent, potentially more toxic, drugs. Alternatively, biopharmaceuticals may hold
Johan Georg Visser +2 more
doaj +1 more source
IMPROVING LAND MANAGEMENT AND PRODUCTIVITY OF CARDAMOM (AMOMUM COMPACTUM) BASED AGROFORESTRY SYSTEM FOR SUPPLY OF ANTI COVID 19 BIOPHARMACEUTICAL RAW MATERIALS [PDF]
Russian Journal of Agricultural and Socio-Economic Sciences, 2022 The aim of the study was to examine the benefit of combination of organic (manure) and an organic fertilizer (NPK) along with the use of biofertilizer to improve cardamon growth and performance as Covid-19 biopharmaceutical raw material.
Reziq M. +3 more
doaj
Immunogenicity of biopharmaceuticals [PDF]
Nephrology Dialysis Transplantation, 2006 The availability of biopharmaceuticals has been increasing over the past decade and as their patents expire, the emergence of biosimilar agents approaches. The primary issue of concern for the safety of these agents is the potential for immunogenicity.
Michele, Kessler +2 more
openaire +2 more sources
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
A theoretical framework for estimation of AUCs in complete and incomplete sampling designs. [PDF]
, 2009 Nonclinical in vivo animal studies have to be completed before starting clinical studies of the pharmacokinetic behavior of a drug in humans. The drug exposure in animal studies is often measured by the area under the concentration versus time curve (AUC)
Jaki, Thomas, Wolfsegger, Martin J.
core +1 more source
Advanced Functional Materials, EarlyView.An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu +14 more
wiley +1 more source
Biopharmaceutical Innovation System in China: System Evolution and Policy Transitions (Pre-1990s-2010s) [PDF]
International Journal of Health Policy and Management, 2015 Background: This article sets up the initial discussion of the evolution of biopharmaceutical innovation in China through the perspective of sectoral innovation system (SIS).
Hao Hu, Chao-Chen Chung
doaj +1 more source
Assessing the similarity of dose response and target doses in two non-overlapping subgroups [PDF]
, 2017 We consider two problems that are attracting increasing attention in clinical dose finding studies. First, we assess the similarity of two non-linear regression models for two non-overlapping subgroups of patients over a restricted covariate space.
Bretz, Frank +4 more
core +2 more sources
Tissue Engineered Human Elastic Cartilage From Primary Auricular Chondrocytes for Ear Reconstruction
Advanced Functional Materials, EarlyView.Despite over three decades of research, no tissue‐engineered solution for auricular reconstruction in microtia patients has reached clinical translation. The key challenge lies in generating functional elastic cartilage ex vivo. Here, we integrate synergistic cell‐biomaterial strategies to engineer auricular grafts with mechanical and histological ...
Philipp Fisch +13 more
wiley +1 more source