Results 51 to 60 of about 30,350 (261)

Physics‐encoded transfer learning for scale‐up modeling of CHO cell bioreactors

AIChE Journal, EarlyView.
Abstract Developing reliable predictive models for mammalian cell bioreactors, particularly Chinese hamster ovary (CHO) cultures widely used in biopharmaceutical manufacturing, remains challenging due to severe data scarcity in industrial‐scale reactors.
Muyang Li, Ming Xiao, Zhe Wu
wiley   +1 more source

Tezepelumab in Chinese Patients With Severe Chronic Rhinosinusitis With Nasal Polyps: A Prespecified Subgroup Analysis of the Phase 3 WAYPOINT Trial

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) in Chinese patients often exhibits a mixed Type 1/2/3 inflammatory phenotype (63%), potentially impacting the efficacy of biologics targeting Type 2 inflammation. This prespecified subgroup analysis of WAYPOINT (NCT04851964) evaluated the efficacy and safety of tezepelumab in Chinese
Li Hu, Houyong Li, Xicai Sun, Quan Liu, Yu Xu, Jiangang Fan, Andrew Foster, Claudia Chen, Yun Chon, Dehui Wang   +9 more
wiley   +1 more source

Harnessing Macrophages for Controlled-Release Drug Delivery: Lessons From Microbes

Frontiers in Pharmacology, 2019
With the effectiveness of therapeutic agents ever decreasing and the increased incidence of multi-drug resistant pathogens, there is a clear need for administration of more potent, potentially more toxic, drugs. Alternatively, biopharmaceuticals may hold
Johan Georg Visser, Anton Du Preez Van Staden, Carine Smith   +2 more
doaj   +1 more source

Considerations for applying bioethics norms to a biopharmaceutical industry setting

BMC Medical Ethics, 2021
Background The biopharmaceutical industry operates at the intersection of life sciences, clinical research, clinical care, public health, and business, which presents distinct operational and ethical challenges.
Luann E. Van Campen, Tatjana Poplazarova, Donald G. Therasse, Michael Turik, The Biopharmaceutical Bioethics Working Group   +4 more
doaj   +1 more source

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

Editorial: Separation Processes in Pharmaceutical Manufacturing

Frontiers in Chemical Engineering, 2022
Cristina Chuck-Hernández, Jia Wei Chew, Karla Mayolo-Deloisa, Bodhisattwa Chaudhuri, Bodhisattwa Chaudhuri   +4 more
doaj   +1 more source

Multi‐Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is a multiorgan disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith, Dominic Sinibaldi, Saifur Rahman, Chia‐Chien Chiang, Anna M. Hansen, Jill Henault, Carlos P. Roca, Shu Wang, Kamelia Zerrouki, Rebecca Filippi, Christopher Groves, Zerai Manna, Jun Chu, Michael Davis, Sarthak Gupta, Christopher Morehouse, Melissa de los Reyes, Rachel Ettinger, Roland Kolbeck, Mariana J. Kaplan, Miguel A. Sanjuan, Richard M. Siegel, Sarfaraz A. Hasni, Kerry A. Casey   +23 more
wiley   +1 more source

A Model for Indigenous Development of Biopharmaceutical Industry: The Case of CinnaGen Company [PDF]

بهبود مدیریت, 2019
Recent studies on technological catch-up show a strategic shift from the whole process towards focusing on the processes. Traditionally, scholars were interested in examining the relationship between local and international sources of knowledge through ...
Fatemeh Mojiri, Alireza Sheikh, Borna Payandehmehr, Mehdi Majidpour   +3 more
doaj  

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Occupational hygiene risk assessment at light speed—a study for protecting worker health and safety in the biopharmaceutical industry

Frontiers in Public Health
BackgroundHazardous substances are ubiquitous in the workplace and improperly controlled exposure may result in severe illness and death. Occupational exposure models can be used to predict the level of exposure workers may experience while performing ...
Paul Kayser, Paul Kayser, Leonid Turczynowicz, Sharyn Gaskin   +3 more
doaj   +1 more source