Results 81 to 90 of about 32,871 (300)
Angewandte Chemie International Edition, EarlyView.Geminal difunctionalization of readily available building blocks provides rapid access to molecular complexity. This work introduces a strategy for installing two distinct functional groups on a carbonyl carbon by transforming it into a donor–donor diazo compound, enabling both batch and flow applications with broad solvent compatibility.
Vincent George +13 more
wiley +1 more source
Three-dimensional Biopharmaceutics and Clinical Considerations of Drugs for Safety and Efficacy: A Review Study [PDF]
Pharmaceutical and Biomedical ResearchBackground: Several drugs today are described with their molecular structures showcasing symmetrical, dissymmetrical, or asymmetrical configurations. Some drugs showing chirality are racemic or pure enantiomeric forms for clinical practice.
Sunday O. Awofisayo +3 more
doaj
Quantification of Cell Subpopulations, Fractions of Dead Cells and Debris in Cell Suspensions by Laser Diffractometry [PDF]
, 1992 Laser diffractometry was employed for size analysis in liver cell and blood cell suspensions to assess its suitability for characterizing cell populations.
Blunk, Torsten, Müller, R. H., Rudt, S.
core
Physiology-based IVIVE predictions of tramadol from in vitro metabolism data [PDF]
, 2014 To predict the tramadol in vivo pharmacokinetics in adults by using in vitro metabolism data and an in vitro-in vivo extrapolation (IVIVE)-linked physiologically-based pharmacokinetic (PBPK) modeling and simulation approach (SimcypA (R)).
Allegaert, Karel +10 more
core +1 more source
The United States Leads the Globe in Venture Capital Funding for Orthopaedic Surgery
Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.Purpose To characterize venture capital (VC) investments in orthopaedic surgery over the past 25 years to evaluate trends in global innovation. Methods All VC investments related to orthopaedic surgery between January 2000 and December 2024 were retrospectively evaluated using the PitchBook database (PitchBook Platform, PitchBook Data.
Mathangi Sridharan +7 more
wiley +1 more source
Silymarin and Silybin: Rejuvenating Traditional Remedies with Modern Delivery Strategies
PharmaceuticsSilymarin, a polyphenolic flavonolignan complex extracted from Silybum marianum (milk thistle), has long been recognized for its hepatoprotective, antioxidant, anti-inflammatory, and anticancer properties.
Xiuyan Li +6 more
doaj +1 more source
Nitrosylated high density lipoprotein is recognized by a scavenger receptor in rat liver.
Journal of Lipid Research, 1989 In order to assess the presence of specific recognition sites for high density lipoprotein (HDL) in vivo, HDL was nitrosylated with tetranitromethane and the decay and liver uptake were compared with that of native HDL.
M F Kleinherenbrink-Stins +5 more
doaj +1 more source
Nasal Drug Delivery Systems: An Overview [PDF]
, 2015 Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades ...
Conway, Barbara R. +3 more
core +1 more source
Arthritis &Rheumatology, EarlyView.Objective The multinational, phase 3, double‐blind, placebo‐controlled TULIP‐SC trial evaluated the efficacy and safety of subcutaneous anifrolumab in adults who have moderate to severe systemic lupus erythematosus (SLE) activity, despite receiving standard therapy. Methods Adults with SLE received subcutaneous anifrolumab 120 mg or placebo once weekly
Susan Manzi +12 more
wiley +1 more source