Results 71 to 80 of about 15,283 (290)

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Three-dimensional Biopharmaceutics and Clinical Considerations of Drugs for Safety and Efficacy: A Review Study [PDF]

Pharmaceutical and Biomedical Research
Background: Several drugs today are described with their molecular structures showcasing symmetrical, dissymmetrical, or asymmetrical configurations. Some drugs showing chirality are racemic or pure enantiomeric forms for clinical practice.
Sunday O. Awofisayo, Akwaowoh E. Akpabio, Emmanuel O. Olorunsola, Matthew I. Arhewoh   +3 more
doaj  

Silymarin and Silybin: Rejuvenating Traditional Remedies with Modern Delivery Strategies

Pharmaceutics
Silymarin, a polyphenolic flavonolignan complex extracted from Silybum marianum (milk thistle), has long been recognized for its hepatoprotective, antioxidant, anti-inflammatory, and anticancer properties.
Xiuyan Li, Han Zhu, Yanhong Wang, Xiwu Zhang, Zhixin Yang, Xueying Yan, Qin Yu   +6 more
doaj   +1 more source

Nitrosylated high density lipoprotein is recognized by a scavenger receptor in rat liver.

Journal of Lipid Research, 1989
In order to assess the presence of specific recognition sites for high density lipoprotein (HDL) in vivo, HDL was nitrosylated with tetranitromethane and the decay and liver uptake were compared with that of native HDL.
M F Kleinherenbrink-Stins, D Schouten, J van der Boom, A Brouwer, D L Knook, T J van Berkel   +5 more
doaj   +1 more source

Apllied Biopharmaceutics

, 2005
xx, 892 hal.; ill ...
Pong, Susana WU, Shargel, Leon
core  

Through the lens of marketing authorization holders: experience in use of real‐world data and real‐world evidence in drug development and regulatory submissions in EU

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The aim of this study was to assess the general and product‐specific experiences of MAHs use of RWD/RWE in medicines development and in their regulatory submissions, and to explore organizational aspects of MAHs related to RWD/RWE. Methods An electronic survey was conducted, and information collected directly from MAHs.
Sini M. Eskola, Aleksandar Gigov, Hubertus G. M. Leufkens, Andrew Bate, Marie Louise De Bruin, Helga Gardarsdottir   +5 more
wiley   +1 more source

Surge Dose® Formulations of NSAIDs Provide for Ultra-Rapid and Consistent Drug Absorption in Both the Fasted and Fed State as Predicted by Physiologically Based Biopharmaceutics Modelling

Background/Objectives: This paper describes the use of physiologically based biopharmaceutics modelling (PBBM) to predict the effect of food on diclofenac and ibuprofen absorption from ultra-rapid-release Surge Dose® tablets.
Harri Dickinson, Zhixin Jiang, Paul A. Dickinson, Ian R. Wilding, Geraldine A. Elliott   +4 more
core   +1 more source

Pharmacokinetics and safety of tezepelumab in children with mild, moderate or severe asthma and adolescents with mild‐to‐moderate asthma

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin and is approved for adolescents and adults with severe asthma. This analysis assessed pharmacokinetics (PK), pharmacodynamics and safety of tezepelumab up to 85 days postdose in adolescents and children.
Anna Lundahl, Jonathan Grigg, Lubna Abuqayyas, Piotr Kuna, Gillian Hunter, Beata Pawlikowska, Jacob Leander, Michael Levin, Atul Gupta, James Paton, Katharine C. Pike, Jane R. Parnes, Gun Almqvist, Stephanie L. Roseti, on behalf of the study investigators   +14 more
wiley   +1 more source

Pharmacokinetics and biopharmaceutics

, 2011
[Extract] Oral dosage forms are widely used due to the convenience of drug administration. There are several steps a dosage form/delivery system has to undergo before it produces a therapeutic response.
Haywood, Alison, Perumal, Omathanu P., Ho, Paul Chi-Lui, Glass, Beverley   +3 more
core   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source