Results 51 to 60 of about 15,283 (290)

Redefining the Minimal Editable Unit of Supramolecular Synthons: A 1→2 Lattice‐Editing Strategy in Ternary Multicomponent Crystals

Advanced Science, EarlyView.
Inspired by skeletal editing, we propose a lattice‐editing strategy that extends the minimal editable unit in supramolecular crystals from individual components to local supramolecular structural units, enabling non‐stoichiometric one‐to‐many substitution while preserving the parent lattice architecture.
Zheng Lin, Honglei Xia, Min Li, Ruihui Wang, Ying Wang, Xiaoyu Feng, Mingjing Tang, Yuan Zhang, Qinghua Zhang   +8 more
wiley   +1 more source

Structural and In Vitro Functional Comparability Analysis of Altebrel™, a Proposed Etanercept Biosimilar: Focus on Primary Sequence and Glycosylation

Pharmaceuticals, 2019
The demand for reliable comparability studies of biosimilars grows with their increased market share. These studies focus on physicochemical, structural, functional and clinical properties to ensure that a biosimilar has no significant differences to the
Ramin Fazel, Yudong Guan, Behrouz Vaziri, Christoph Krisp, Laura Heikaus, Amirhossein Saadati, Siti Nurul Hidayah, Manasi Gaikwad, Hartmut Schlüter   +8 more
doaj   +1 more source

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source

Conference Report: Pharmaceutical Technology, Biopharmaceutics and Drug Delivery

, 2011
The 40th annual international conference of the Korean Society of Pharmaceutical Sciences and Technology on Pharmaceutical Technology, Biopharmaceutics and Drug Delivery was held on 2–3 December 2010 in Jeju Special Self-Governing Providence, Korea, to ...
Beom-Jin Lee, Yu Seok Youn
core   +1 more source

Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy

Advanced Science, EarlyView.
A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu, Jing‐Chu Hu, Ye‐Fan Hu, Wen‐Jun Li, Li Rong, Ren‐Hao Li, Yuan Yao, Lehan Hu, Xiao‐Lei Wang, Bao‐Zhong Zhang, Yicheng Lu, Shing‐Fung Chow, Canhui Su, Thomas Yau, Clive Yik‐Sham Chung, Jian‐Dong Huang   +15 more
wiley   +1 more source

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

Advanced Science, EarlyView.
TROP2 is identified as a novel tumor‐selective lysosomal‐targeting receptor with established clinical relevance. TROP2‐targeting chimeras (TRTACs) are developed by genetically fusing a TROP2‐binding nanobody to nanobodies against specific target proteins.
Luping Chen, Xinying Fu, Wenqian Dong, Xiaobei Deng, Simin Chen, Fujun Wang, Jian Zhao, Shiqun Shao, Liqiang Fan, Jingyu Zhang, Lixin Zhang   +10 more
wiley   +1 more source

Immune Checkpoint Inhibitor as a Fifth Component of Lipid Nanoparticles Enables Lymph Node‐Targeting and Augments mRNA Vaccine Efficacy

Advanced Science, EarlyView.
Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha, Jaehyun Kim, Seyoung Kim, Gonna Somu Naidu, Sungchan Cho, Seok‐Beom Yong   +5 more
wiley   +1 more source

The myeloperoxidase inhibitor mitiperstat (AZD4831) does not prolong the QT interval at expected therapeutic doses

Pharmacology Research & Perspectives
Mitiperstat is a myeloperoxidase inhibitor in clinical development for treatment of patients with heart failure and preserved or mildly reduced ejection fraction, non‐alcoholic steatohepatits and chronic obstructive pulmonary disease.
Joanna Parkinson, Jesper Sundell, Dinko Rekić, Karin Nelander, Hans Ericsson, Ahmad Ebrahimi, Corina Dota, Mikael Sunnåker   +7 more
doaj   +1 more source

Insights into Streptomyces spp. isolated from the rhizospheric soil of Panax notoginseng: isolation, antimicrobial activity and biosynthetic potential for polyketides and non-ribosomal peptides

BMC Microbiology, 2020
Background Streptomycetes from the rhizospheric soils are a rich resource of novel secondary metabolites with various biological activities. However, there is still little information related to the isolation, antimicrobial activity and biosynthetic ...
Fei Peng, Meng-Yue Zhang, Shao-Yang Hou, Juan Chen, Ying-Ying Wu, Yi-Xuan Zhang   +5 more
doaj   +1 more source

The complete chloroplast genome of Melicope pteleifolia (Rutaceae), a traditional medicinal plant in Southeast China

Mitochondrial DNA. Part B. Resources, 2021
Meclicope pteleifolia is a traditional medicinal herb and edible plant in Southeast China. Here, we report the complete chloroplast genome of M. pteleifolia. The chloroplast genome is 159,012 bp in length with 38.33% GC content, containing a small single-
Jingwei Yu, Luxi Chen, Jianwen Mao, Xiaobao Jin, Juan Shen   +4 more
doaj   +1 more source