Results 31 to 40 of about 10,035 (161)

Prodigiosin from Serratia Marcescens in Cockroach Inhibits the Proliferation of Hepatocellular Carcinoma Cells through Endoplasmic Reticulum Stress-Induced Apoptosis

Molecules, 2022
Hepatocellular carcinoma (HCC) is the most common primary liver malignant tumor, and the targeted therapy for HCC is very limited. Our previous study demonstrated that prodigiosin(PG), a secondary metabolite from Serratia marcescens found in the ...
Jie Wang, Hancong Liu, Liuchong Zhu, Jingyi Wang, Xiongming Luo, Wenbin Liu, Yan Ma   +6 more
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Stem cell research in Indonesia from 2003 to 2022: A bibliometrics analysis [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Stem cell research has become popular in Indonesia for more than a decade. The scope of research involves in vitro to animal studies as well as human trials. However, no evidence proved its trend.
Imam Rosadi, Karina Karina, Pitra Ariesta Sinta Dewi, Anggraini Barlian, Thania Fathimah Az Zahra, Viol Dhea Kharisma, Arif Nur Muhammad Ansori   +6 more
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Structural and In Vitro Functional Comparability Analysis of Altebrel™, a Proposed Etanercept Biosimilar: Focus on Primary Sequence and Glycosylation

Pharmaceuticals, 2019
The demand for reliable comparability studies of biosimilars grows with their increased market share. These studies focus on physicochemical, structural, functional and clinical properties to ensure that a biosimilar has no significant differences to the
Ramin Fazel, Yudong Guan, Behrouz Vaziri, Christoph Krisp, Laura Heikaus, Amirhossein Saadati, Siti Nurul Hidayah, Manasi Gaikwad, Hartmut Schlüter   +8 more
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The myeloperoxidase inhibitor mitiperstat (AZD4831) does not prolong the QT interval at expected therapeutic doses

Pharmacology Research & Perspectives
Mitiperstat is a myeloperoxidase inhibitor in clinical development for treatment of patients with heart failure and preserved or mildly reduced ejection fraction, non‐alcoholic steatohepatits and chronic obstructive pulmonary disease.
Joanna Parkinson, Jesper Sundell, Dinko Rekić, Karin Nelander, Hans Ericsson, Ahmad Ebrahimi, Corina Dota, Mikael Sunnåker   +7 more
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Insights into Streptomyces spp. isolated from the rhizospheric soil of Panax notoginseng: isolation, antimicrobial activity and biosynthetic potential for polyketides and non-ribosomal peptides

BMC Microbiology, 2020
Background Streptomycetes from the rhizospheric soils are a rich resource of novel secondary metabolites with various biological activities. However, there is still little information related to the isolation, antimicrobial activity and biosynthetic ...
Fei Peng, Meng-Yue Zhang, Shao-Yang Hou, Juan Chen, Ying-Ying Wu, Yi-Xuan Zhang   +5 more
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The complete chloroplast genome of Melicope pteleifolia (Rutaceae), a traditional medicinal plant in Southeast China

Mitochondrial DNA. Part B. Resources, 2021
Meclicope pteleifolia is a traditional medicinal herb and edible plant in Southeast China. Here, we report the complete chloroplast genome of M. pteleifolia. The chloroplast genome is 159,012 bp in length with 38.33% GC content, containing a small single-
Jingwei Yu, Luxi Chen, Jianwen Mao, Xiaobao Jin, Juan Shen   +4 more
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Development and Characterization of a Primary Ciliated Porcine Airway Model for the Evaluation of In Vitro Mucociliary Clearance and Mucosal Drug Delivery

Pharmaceutics
Background/Objectives: In vitro models play a crucial role in preclinical respiratory research, enabling the testing and screening of mucosal formulations, dosage forms, and inhaled drugs.
Janik Martin, Veronika Neubauer, Rebecca Rittersberger, Simon Treitler, Patrick Kopp, Cemre Günday, Iman Shrimo, Annabelle Dabbars, Frank Rosenau, Akif Emre Türeli, Nazende Günday-Türeli, Oliver Haedicke-Peters, Katharina Schindowski   +12 more
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Developing Clinically Relevant Dissolution Specifications for Oral Drug Products—Industrial and Regulatory Perspectives

Pharmaceutics, 2019
A meeting that was organized by the Academy of Pharmaceutical Sciences Biopharmaceutics and Regulatory Sciences focus groups focused on the challenges of Developing Clinically Relevant Dissolution Specifications (CRDS) for Oral Drug Products.
Mark McAllister, Talia Flanagan, Karin Boon, Xavier Pepin, Christophe Tistaert, Masoud Jamei, Andreas Abend, Evangelos Kotzagiorgis, Claire Mackie   +8 more
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CYD0281, a Bcl-2 BH4 domain antagonist, inhibits tumor angiogenesis and breast cancer tumor growth

BMC Cancer, 2023
Background B-cell lymphoma 2 (Bcl-2) family proteins are key regulators of apoptosis, which possess four conserved Bcl-2 homologies (BH) domains. Among the BH domains, the BH3 domain is considered as a potent ‘death domain’ while the BH4 domain is ...
Yihua Lin, Yiling Zhao, Minggui Chen, Zishuo Li, Qiao Liu, Jian Chen, Yi Ding, Chunyong Ding, Ye Ding, Cuiling Qi, Lingyun Zheng, Jiangchao Li, Rongxin Zhang, Jia Zhou, Lijing Wang, Qian-Qian Zhang   +15 more
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Safety and Biopharmaceutical Challenges of Excipients in Off-Label Pediatric Formulations

International Journal of General Medicine, 2020
Anteneh Belayneh,1 Ebisa Tadese,2 Fantahun Molla2 1Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia; 2Department of Pharmaceutics, School of Pharmacy, College of Health Sciences, Mekelle University ...
Belayneh A, Tadese E, Molla F
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