Results 41 to 50 of about 10,035 (161)

Biological and Biosimilar Medicines in Contemporary Pharmacotherapy for Metabolic Syndrome

Pharmaceutics
The discovery of new drugs offers valuable alternatives, particularly for treating diseases that are resistant to existing therapies or involving complex, multi-organ conditions such as metabolic syndrome. Although treatment algorithms are generally well
Wiktoria Górecka, Daria Berezovska, Monika Mrozińska, Grażyna Nowicka, Monika E. Czerwińska   +4 more
doaj   +1 more source

Correlations of mRNA Levels among Efflux Transporters, Transcriptional Regulators, and Scaffold Proteins in Non-Small-Cell Lung Cancer

Canadian Journal of Infectious Diseases and Medical Microbiology, 2021
Multidrug resistance (MDR) due to enhanced drug efflux activity of tumor cells can severely impact the efficacy of antitumor therapies. We recently showed that increased activity of the efflux transporter P-glycoprotein (P-gp) associated with activation ...
Xieyi Zhang, Wangyang Liu, Kazue Edaki, Yuta Nakazawa, Hiroki Kamioka, Atsushi Fujita, Ryoichi Onozato, Misa Iijima, Shigeru Tsuchida, Takahiro Arai, Yukiyoshi Fujita, Kenta Mizoi, Takuo Ogihara   +12 more
doaj   +1 more source

Three-dimensional Biopharmaceutics and Clinical Considerations of Drugs for Safety and Efficacy: A Review Study [PDF]

Pharmaceutical and Biomedical Research
Background: Several drugs today are described with their molecular structures showcasing symmetrical, dissymmetrical, or asymmetrical configurations. Some drugs showing chirality are racemic or pure enantiomeric forms for clinical practice.
Sunday O. Awofisayo, Akwaowoh E. Akpabio, Emmanuel O. Olorunsola, Matthew I. Arhewoh   +3 more
doaj  

Silymarin and Silybin: Rejuvenating Traditional Remedies with Modern Delivery Strategies

Pharmaceutics
Silymarin, a polyphenolic flavonolignan complex extracted from Silybum marianum (milk thistle), has long been recognized for its hepatoprotective, antioxidant, anti-inflammatory, and anticancer properties.
Xiuyan Li, Han Zhu, Yanhong Wang, Xiwu Zhang, Zhixin Yang, Xueying Yan, Qin Yu   +6 more
doaj   +1 more source

Nitrosylated high density lipoprotein is recognized by a scavenger receptor in rat liver.

Journal of Lipid Research, 1989
In order to assess the presence of specific recognition sites for high density lipoprotein (HDL) in vivo, HDL was nitrosylated with tetranitromethane and the decay and liver uptake were compared with that of native HDL.
M F Kleinherenbrink-Stins, D Schouten, J van der Boom, A Brouwer, D L Knook, T J van Berkel   +5 more
doaj   +1 more source

Establishing an innovative carbohydrate metabolic pathway for efficient production of 2-keto-l-gulonic acid in Ketogulonicigenium robustum initiated by intronic promoters

Microbial Cell Factories, 2018
Background 2-Keto-l-gulonic acid (2-KGA), the precursor of vitamin C, is currently produced by two-step fermentation. In the second step, l-sorbose is transformed into 2-KGA by the symbiosis system composed of Ketogulonicigenium vulgare and Bacillus ...
Cai-Yun Wang, Ye Li, Zi-Wei Gao, Li-Cheng Liu, Meng-Yue Zhang, Tian-Yuan Zhang, Chun-Fu Wu, Yi-Xuan Zhang   +7 more
doaj   +1 more source

(Re)defining biopharmaceutical [PDF]

Nature Biotechnology, 2008
Vested interests are redefining, rebranding and co-opting what is 'biopharmaceutical'. This is not just a matter of semantics-the core identity of the biotech industry and its products is at stake.
openaire   +2 more sources

Biopharmaceutical applications of nanogold

Saudi Pharmaceutical Journal, 2010
The application of nanogold in biopharmaceutical field is reviewed in this work. The properties of nanogold including nanogold surface Plasmon absorption and nanogold surface Plasmon light scattering are illustrated. The physical, chemical, biosynthesis methods of nanogold preparation are presented.
Alanazi, Fars K., Radwan, Awwad A., Alsarra, Ibrahim A.   +2 more
openaire   +2 more sources

Adult and pediatric physiologically‐based biopharmaceutics modeling to explain lamotrigine immediate release absorption process

CPT: Pharmacometrics & Systems Pharmacology
Physiologically‐based biopharmaceutics modeling (PBBM) has potential to accelerate the development of new drug and formulations. An important application of PBBM is for special populations such as pediatrics that have pharmacokinetics dependent on the ...
Edilainy Rizzieri Caleffi‐Marchesini, Amanda Antunes Herling, Julia Macente, Rodolfo Hernandes Bonan, Priscila deFreitas Lima, Rafaela Moreno, Veriano Alexandre, Nitin Bharat Charbe, Fernanda Belincanta Borghi‐Pangoni, Rodrigo Cristofoletti, Andréa Diniz   +10 more
doaj   +1 more source

Inhalation of Immuno-Therapeutics/-Prophylactics to Fight Respiratory Tract Infections: An Appropriate Drug at the Right Place!

Frontiers in Immunology, 2019
Thomas Sécher, Thomas Sécher, Alexie Mayor, Alexie Mayor, Nathalie Heuzé-Vourc'h, Nathalie Heuzé-Vourc'h   +5 more
doaj   +1 more source