Results 41 to 50 of about 15,283 (290)

Paediatric oral biopharmaceutics : key considerations and current challenges [PDF]

, 2014
The complex process of oral drug absorption is influenced by a host of drug and formulation properties as well as their interaction with the gastrointestinal environment in terms of drug solubility, dissolution, permeability and pre-systemic metabolism ...
Batchelor, Hannah K., Fotaki, Nikoletta, Klein, Sandra   +2 more
core   +4 more sources

The evaluation of valsartan biopharmaceutics properties.

, 2020
Background: Solubility, intestinal permeability and dissolution are the main factors that govern the rate and extent of drugs absorption and are directly related to bioavailability.
Souza, Jacqueline de, Caldeira, Tamires Guedes, Barcellos, Neila Marcia Silva, Mapa, Bruna de Carvalho, Gomes, Bruna Pegorelli, Croce, Carolina Carvalho Della, Castro, Lara Maria Lopes de, Soares, Anna Flávia Matos   +7 more
core   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Hydration‐Gated Photoinduced Electron Transfer in BODIPY Dyes

Angewandte Chemie, EarlyView.
Hydration switches photoinduced electron transfer (PET) ON in alkoxy‐coordinated BODIPY dyes via specific hydrogen bonding. This gating yields a fluorescence lifetime span of ∼6 ns, enabling fluorescence lifetime imaging microscopy (FLIM) contrast in live cells and organoids. ABSTRACT Fluorescent probes based on photoinduced electron transfer (PET) are
Venkata N. K. Mamillapalli, Irina A. Okkelman, Fatima Akhssas, Greta Sambucari, Angela C. Debruyne, Dinesh Beniwal, Christophe Bucher, Mariangela Di Donato, Ruslan I. Dmitriev, Mikhail A. Filatov   +9 more
wiley   +2 more sources

Antimicrobial compounds were isolated from the secondary metabolites of Gordonia, a resident of intestinal tract of Periplaneta americana

AMB Express, 2021
Gordonia sp. are members of the actinomycete family, their contribution to the environment improvement and environmental protection by their biological degradation ability, but there are few studies on the antimicrobial activity of their secondary ...
Yan Ma, Minhua Xu, Hancong Liu, Tiantian Yu, Ping Guo, Wenbin Liu, Xiaobao Jin   +6 more
doaj   +1 more source

Drug Delivery to the Posterior Segment of the Eye: Biopharmaceutic and Pharmacokinetic Considerations [PDF]

, 2020
The treatment of the posterior-segment ocular diseases, such as age-related eye diseases (AMD) or diabetic retinopathy (DR), present a challenge for ophthalmologists due to the complex anatomy and physiology of the eye. This specialized organ is composed
Luzardo-Alvarez, A., Diaz Tomé, Victoria, Xurxo García-Otero, Francisco Otero-Espinar, Fernández Varela, Ramon, Victoria Díaz-Tomé, Otero Espinar, Francisco, Andrea Conde-Penedo, Asteria Luzardo-Álvarez, Luaces Rodríguez, Andrea, Conde-Penedo, A., Fernández Ferreiro, Anxo, Andrea Luaces-Rodríguez, Rubén Varela-Fernández, García Otero, Xurxo, Anxo Fernández-Ferreiro   +15 more
core   +1 more source

Innovative Test Strip‐Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves

Advanced Science, EarlyView.
Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa, Hui Yuan, Jingui Ma, Zhigang Yang, Mei Wang, Weibiao Wang, Lingling Yang, Fen Ma, Weiman Zhang, Gidion Wilson Mening'oo, Guoning Chen, Xueqin Ma   +11 more
wiley   +1 more source

Prodigiosin from Serratia Marcescens in Cockroach Inhibits the Proliferation of Hepatocellular Carcinoma Cells through Endoplasmic Reticulum Stress-Induced Apoptosis

Molecules, 2022
Hepatocellular carcinoma (HCC) is the most common primary liver malignant tumor, and the targeted therapy for HCC is very limited. Our previous study demonstrated that prodigiosin(PG), a secondary metabolite from Serratia marcescens found in the ...
Jie Wang, Hancong Liu, Liuchong Zhu, Jingyi Wang, Xiongming Luo, Wenbin Liu, Yan Ma   +6 more
doaj   +1 more source

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Stem cell research in Indonesia from 2003 to 2022: A bibliometrics analysis [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Stem cell research has become popular in Indonesia for more than a decade. The scope of research involves in vitro to animal studies as well as human trials. However, no evidence proved its trend.
Imam Rosadi, Karina Karina, Pitra Ariesta Sinta Dewi, Anggraini Barlian, Thania Fathimah Az Zahra, Viol Dhea Kharisma, Arif Nur Muhammad Ansori   +6 more
doaj   +1 more source