Results 91 to 100 of about 1,099,223 (288)

Natural Design of a Stabilized Cross‐β Fold: Structure of the FuA FapC from Pseudomonas Sp. UK4 Reveals a Critical Role for Stacking of Imperfect Repeats

Advanced Materials, EarlyView.
We report a 3.2 Å cryoEM structure of functional amyloid protein FapC from Pseudomonas sp. UK4, an essential component of bacterial biofilm, which reveals a Greek key‐shaped protofilament, supports bioinformatically determined motifs, nuances AlphaFold predictions, emphasizes heterogeneous cross‐β stacking in amyloid cross‐seeding and shows strain ...
Yanting Jiang, Samuel Peña‐Díaz, Zhefei Zhang, Anders Ogechi Hostrup Daugberg, Marcos López Hernández, Janni Nielsen, Qiaojie Huang, Shenghan Qin, Morten K. D. Dueholm, Mingdong Dong, Jan Skov Pedersen, Qin Cao, Daniel E. Otzen, Huabing Wang   +13 more
wiley   +1 more source

Activation and Stabilization Strategies of Aluminum Metal Anode Toward High Performance Aqueous Al Metal Batteries

Advanced Materials, EarlyView.
This review spotlights the critical challenges faced by aluminum metal anodes and aqueous electrolytes. Recent progress on activating and stabilizing Al metal anode is summarized and discussed in terms of two aspects, including anode engineering and electrolyte optimization. Finally, some revelatory insights and possible strategies are provided for the
Huaming Yu, Xiaofeng Zhang, Yaxin Wang, Meilin Li, Wei Chen, Zhe Hu, Minshen Zhu, Yang Huang   +7 more
wiley   +1 more source

NetPyNE, a tool for data-driven multiscale modeling of brain circuits

eLife, 2019
Biophysical modeling of neuronal networks helps to integrate and interpret rapidly growing and disparate experimental datasets at multiple scales. The NetPyNE tool (www.netpyne.org) provides both programmatic and graphical interfaces to develop data ...
Salvador Dura-Bernal, Benjamin A Suter, Padraig Gleeson, Matteo Cantarelli, Adrian Quintana, Facundo Rodriguez, David J Kedziora, George L Chadderdon, Cliff C Kerr, Samuel A Neymotin, Robert A McDougal, Michael Hines, Gordon MG Shepherd, William W Lytton   +13 more
doaj   +1 more source

Leveraging Design of Experiments to Unravel the Amplification Mechanism of Single‐Molecule Wide‐Field Biosensors

Advanced Materials Interfaces, EarlyView.
Detecting single molecules on large interfaces is challenging due to minimal perturbations on the sensing surface. Some biological systems achieve this feat using amplification mechanisms, but their molecular foundations remain unclear. To investigate, a Design of Experiments (DoE) approach examines how pH and ionic strength in conditioning solutions ...
Michele Catacchio, Mariapia Caputo, Lucia Sarcina, Cinzia Di Franco, Matteo Piscitelli, Erika Castrignanò, Paolo Bollella, Gaetano Scamarcio, Eleonora Macchia, Luisa Torsi   +9 more
wiley   +1 more source

Solvation free energy of light alkanes in polar and amphiphilic environments

Bibechana, 2018
Computer simulations of molecular models are powerful technique that have improved the under- standing of many biochemical phenomena. The method is frequently applied to study the motions of biological macromolecules such as protein and nucleic acids ...
Sunil Pokharel, Shyam Prakash Khanal, N P Adhikari   +2 more
doaj   +3 more sources

Biophysical Mechanisms Mediating Fibrin Fiber Lysis

BioMed Research International, 2017
The formation and dissolution of blood clots is both a biochemical and a biomechanical process. While much of the chemistry has been worked out for both processes, the influence of biophysical properties is less well understood. This review considers the
N. Hudson
semanticscholar   +1 more source

Efficient and Realistic Brain Simulation: A Review and Design Guide for Memristor‐Based Approaches

Advanced Materials Technologies, EarlyView.
Memristor‐based emulation of Hodgkin‐Huxley neuron models is investigated, by defining the ideal device characteristics needed for accurate ion‐channel representation and reviewing existing works targeting memristive replication of biological realistic neural behavior.
Lennart Paul Liong Landsmeer, Muhammad Ali Siddiqi, Heba Abunahla, Mario Negrello, Said Hamdioui, Christos Strydis   +5 more
wiley   +1 more source

Visualization of Chromatin Decompaction and Break Site Extrusion as Predicted by Statistical Polymer Modeling of Single-Locus Trajectories

Cell Reports, 2017
Chromatin moves with subdiffusive and spatially constrained dynamics within the cell nucleus. Here, we use single-locus tracking by time-lapse fluorescence microscopy to uncover information regarding the forces that influence chromatin movement following
Assaf Amitai, Andrew Seeber, Susan M. Gasser, David Holcman   +3 more
doaj   +1 more source

Dynamic Structural Colors in Cholesteric Cellulose Composites: Achieving Spatial and Temporal Control

Advanced Optical Materials, EarlyView.
By combining static and time‐resolved optical, structural, and rheological techniques, we demonstrate that the blue‐shift upon solidification of ethyl cellulose‐acrylic acid mesophases corresponds to the reorientation of cholesteric domains. Modulating the mesophase chain mobility and photopolymerization reaction kinetics enables solid chiral nematic ...
Simona G. Fine, Charmaine Guo, Cécile A. C. Chazot   +2 more
wiley   +1 more source

Characterization of Electromechanical Delay Based on a Biophysical Multi-Scale Skeletal Muscle Model

Frontiers in Physiology, 2019
Skeletal muscles can be voluntary controlled by the somatic nervous system yielding an active contractile stress response. Thereby, the active muscle stresses are transmitted to the skeleton by a cascade of connective tissue and thus enable motion.
Laura Schmid, T. Klotz, T. Siebert, O. Röhrle   +3 more
semanticscholar   +1 more source