Results 111 to 120 of about 1,142,090 (245)

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Surface Interactions and Mechanical Properties Shaping Biofilm Dynamics in S. aureus and P. aeruginosa

Journal of Global Antimicrobial Resistance
This study comprehensively investigates biofilm formation, and exploring its various biophysical properties like adhesion, surface roughness, cell stiffness, and cell surface hydrophobicity. The study is focused on five foodborne biofilm-positive strains
Shaista Urooj
doaj   +1 more source

Biophysics of the cochlea. II. Steady-state non linear phenomena.

, 1996
Nonlinearities affecting cochlear mechanics produce appreciable compression in the basilar membrane (BM) input/output (I/O) functions at the characteristic frequency for sound-pressure levels (SPLs) as low as 20 dB (re: 20 mu Pa). This is thought to depend upon saturation of the outer hair cell (OHC) mechanoelectrical transducer (MET).
R. NOBILI, MAMMANO, FABIO
openaire   +1 more source

A continuous-binding cross-linker model for passive airway smooth muscle.

, 2010
Although the active properties of airway smooth muscle (ASM) have garnered much modeling attention, the passive mechanical properties are not as well studied. In particular, there are important dynamic effects observed in passive ASM, particularly strain-
Lauzon, AM, Tawhai, Merryn, Sneyd, A, Donovan, Graham, Bullimore, SR, Elvin, AJ, Bates, JH   +6 more
core   +1 more source

Human Foetal Neuroblasts Exhibit BK Channel‐Dependent Membrane Voltage Oscillations upon Depolarization

Advanced Science, EarlyView.
Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi, Federica Cherchi, Martina Venturini, Federico Tommasi, Sandro Gonzi, Chiara Capacci, Giulia Guarnieri, Pasquale Gallina, Annamaria Morelli, Anna Maria Pugliese   +9 more
wiley   +1 more source

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

Rheological phenomena in focus /

, 1993
More than possibly any other scientific discipline, rheology is easily visualized and the relevant literature contains many excellent photographs of unusual and often bizarre phenomena.
Walters, Kenneth., Boger, D. V.
core  

Red Blood Cells as Endogenous Biotweezers for Optical Micromanipulation In Vivo

Advanced Science, EarlyView.
By synergistically integrating the long‐distance manipulation fiber probe (LDMFP) and endogenous red blood cells (RBCs) as biocompatible optical elements, a natural RBC biotweezer was developed for the desired microparticle manipulation and immune cell activation within living vasculature, which might offer an alternative tool for intravital optical ...
Tong Yang, Xinyu Ren, Dalin Ma, Hao Pang, Wei Chen, Kaize Cai, Mei Yuan, Bingzhi Zhang, Zufang Lin, Xiaoshuai Liu   +9 more
wiley   +1 more source

Protein drift-diffusion in membranes with non-equilibrium fluctuations arising from gradients in concentration or temperature.

PLoS Computational Biology
We investigate proteins within heterogeneous cell membranes where non-equilibrium phenomena arises from spatial variations in concentration and temperature.
Dev Jasuja, Paul J Atzberger
doaj   +1 more source

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source