Results 111 to 120 of about 1,181,476 (312)

NetPyNE, a tool for data-driven multiscale modeling of brain circuits

eLife, 2019
Biophysical modeling of neuronal networks helps to integrate and interpret rapidly growing and disparate experimental datasets at multiple scales. The NetPyNE tool (www.netpyne.org) provides both programmatic and graphical interfaces to develop data ...
Salvador Dura-Bernal, Benjamin A Suter, Padraig Gleeson, Matteo Cantarelli, Adrian Quintana, Facundo Rodriguez, David J Kedziora, George L Chadderdon, Cliff C Kerr, Samuel A Neymotin, Robert A McDougal, Michael Hines, Gordon MG Shepherd, William W Lytton   +13 more
doaj   +1 more source

Granular Hydrogels as Brittle Yield Stress Fluids

Advanced Materials, EarlyView.
This work reports the Kamani‐Donley‐Rogers yield stress fluid model can describe granular hydrogel deformation. The model robustly captures transient rheology and self‐healing behavior for granular gels of varying composition using only six parameters. This framework provides new insight regarding the effect of material parameters on granular yielding ...
Gunnar B. Thompson, Jiye Lee, Krutarth M. Kamani, Noah Flores‐Velasco, Simon A. Rogers, Brendan A. C. Harley   +5 more
wiley   +1 more source

Biophysical Mechanisms Mediating Fibrin Fiber Lysis

BioMed Research International, 2017
The formation and dissolution of blood clots is both a biochemical and a biomechanical process. While much of the chemistry has been worked out for both processes, the influence of biophysical properties is less well understood. This review considers the
N. Hudson
semanticscholar   +1 more source

Dual‐Selective Terahertz‐Nanodisc Metasurfaces for Exploring Neurotransmitter Dynamics beyond Spectral Limitations

Advanced Materials, EarlyView.
Observation and detection of neurotransmitter dynamics in aqueous system has been hurdle for analytical fields due to its weak and reversible nature. A terahertz‐nanodisc metasurface which implements comprehensive detection over conformational change and selective sensing is introduced. Utilizing the THz regime photonics and biomimetic environment with
Taeyeon Kim, Yeon Kyung Lee, Yeeun Roh, Jaehun Park, Yong‐Sang Ryu, Hyun Seok Song, Minah Seo   +6 more
wiley   +1 more source

Visualization of Chromatin Decompaction and Break Site Extrusion as Predicted by Statistical Polymer Modeling of Single-Locus Trajectories

Cell Reports, 2017
Chromatin moves with subdiffusive and spatially constrained dynamics within the cell nucleus. Here, we use single-locus tracking by time-lapse fluorescence microscopy to uncover information regarding the forces that influence chromatin movement following
Assaf Amitai, Andrew Seeber, Susan M. Gasser, David Holcman   +3 more
doaj   +1 more source

Activation and Stabilization Strategies of Aluminum Metal Anode Toward High Performance Aqueous Al Metal Batteries

Advanced Materials, EarlyView.
This review spotlights the critical challenges faced by aluminum metal anodes and aqueous electrolytes. Recent progress on activating and stabilizing Al metal anode is summarized and discussed in terms of two aspects, including anode engineering and electrolyte optimization. Finally, some revelatory insights and possible strategies are provided for the
Huaming Yu, Xiaofeng Zhang, Yaxin Wang, Meilin Li, Wei Chen, Zhe Hu, Minshen Zhu, Yang Huang   +7 more
wiley   +1 more source

Characterization of Electromechanical Delay Based on a Biophysical Multi-Scale Skeletal Muscle Model

Frontiers in Physiology, 2019
Skeletal muscles can be voluntary controlled by the somatic nervous system yielding an active contractile stress response. Thereby, the active muscle stresses are transmitted to the skeleton by a cascade of connective tissue and thus enable motion.
Laura Schmid, T. Klotz, T. Siebert, O. Röhrle   +3 more
semanticscholar   +1 more source

Mixed Ionic and Electronic Charge Transport in Conductive Protein Fibers Revealed with DC Electrical Measurements

Advanced Materials, EarlyView.
M13 bacteriophage films deposited on micro interdigitated electrodes behave as a Randles simplified equivalent circuit under direct current. We derive contact and film resistance as well as capacitance of films of M13 phages, aromatic curli fibers or pilA‐containing nanowires.
Daniel Modafferi, Xinxin Hao, Kingsley L.‐J. Wong, Juliana Ferraro, Weijia Zhang, Oliver Xie, Noémie‐Manuelle Dorval Courchesne   +6 more
wiley   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Engineering Aging: Approaches to Model and Deconstruct Biological Complexity

Advanced Materials, EarlyView.
The macro‐experiences of aging are the result of an accumulation of micro‐changes that occur over time. Abstract The disparity between the global increase in life expectancy and the steady decline in health outcomes with age has been a major driver for developing new ways to research aging.
Habib Joukhdar, Sunny Shinchen Lee, Thomas R. Cox, Yu Suk Choi, Steven G. Wise, Jennifer L. Young, Giselle C. Yeo, Khoon S. Lim   +7 more
wiley   +1 more source