Results 111 to 120 of about 32,154 (264)

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Cell Cycle‐Specific Regulation of Centrosome Clustering Dynamics in Cancer Cells by the Multifunctional Kinesin HSET

Advanced Science, EarlyView.
CDK5RAP2 associates with the kinesin HSET and forms co‐condensates. HSET motors drive the directional transport of CDK5RAP2 condensates toward microtubule minus ends. During mitosis, HSET self‐assembly further stabilizes clustered centrosomes, thereby enabling pseudo‐bipolar spindle formation in cancer cells with supernumerary centrosomes. Upon mitotic
Po‐Pang Chen, Athira Saju, Chia‐Chou Wu, Tzu‐Han Weng, Su‐Yi Tsai, Tzu‐Lun Huang, Jia‐Ying Su, Chien‐Ling Lin, Yu‐Chun Lin, See‐Yeun Ting, Sheng‐hong Chen, Kuo‐Chiang Hsia   +11 more
wiley   +1 more source

Electric‐Field‐Driven Bilayer Interphase from Oxygenated Nanodiamond‐Carbon Nanoparticles for Dendrite‐Free Lithium Metal Batteries

Advanced Energy Materials, EarlyView.
Electric‐field‐driven carbon migration within an oxygen‐functionalized nanodiamond/carbon composite induces the formation of a vertically graded interphase that homogenizes Li‐ion flux and suppresses dendritic nucleation. This hierarchically organized structure stabilizes the electrode–electrolyte interface and delivers durable, dendrite‐free operation
Jaeseong Kim, Incheol Heo, Dong‐Kyung Kim, Min Seok Kang, Ji Hee Kwon, Byeong‐Seon An, Keir C. Neuman, Byung‐Hyun Kim, Hak‐Sung Jung, Won Cheol Yoo   +9 more
wiley   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Severe, Non‐apneic Respiratory Dysfunction and Hypoxia following Generalized Convulsive Seizures

Annals of Neurology, EarlyView.
Objective Sudden unexpected death in epilepsy (SUDEP) is a devastating consequence of some generalized convulsive seizures (GCS). Recent work has focused on seizure related apnea as a biomarker of SUDEP risk, frequently without characterizing the adequacy of non‐apneic ventilation or identifying other dysfunctional breathing patterns.
Haley E. Pysick, Rup K. Sainju, Roshni Nair, Deidre N. Dragon, Eduardo Bravo, Laura Vilella, Xiaojin Li, Samden D. Lhatoo, George B. Richerson, Brian K. Gehlbach   +9 more
wiley   +1 more source

Biophysical modeling of dynamical optical phenomena induced by diagnostic biomarkers

Summarization: Introduction -- 2. The modeling process of metabolic dynamic systems -- 3. From cells to epithelial tissues -- 4. Cervical intraepithelial neoplasia (CIN)
openaire   +1 more source

Tau Pathology in Alzheimer's Disease Uniquely Affects Sulcal Depths

Annals of Neurology, EarlyView.
Objective Though it is widely known that tau deposition affects brain structure, the precise localization of these effects is poorly understood, especially in relation to gyral and sulcal anatomy. We investigated whether tau pathology in Alzheimer's disease (AD) preferentially affects sulci, and particularly sulcal depths.
Samira A. Maboudian, Corrina S. Fonseca, Adam C. Martersteck, Yishu Chao, Yuheng Chen, Daniela Ushizima, Duygu Tosun, Lea T. Grinberg, Kevin S. Weiner, William J. Jagust, for the Alzheimer's Disease Neuroimaging Initiative   +10 more
wiley   +1 more source

A cautionary tale about urban trees: could ecoservice monetary estimates become economic sleights of hand? [PDF]

Bioscience
Van Stan JT, Mueller KE, Wiitala MO, Simmons J, Noren BJ, Lin M, Huang Q, Porada P, Endreny TA.   +8 more
europepmc   +1 more source

Unraveling Synthetase's Mode of Action: The Pyrrolysyl‐tRNA Synthetase Dimer Uses Secondary Binding Sites in the Cell

Angewandte Chemie International Edition, EarlyView.
The pyrrolysyl‐tRNA synthetase dimer exhibits an alternating mode of action of its monomers within its catalytic cycle, which is realized upon occupation of secondary binding sites located at the intermonomer interfaces outside the catalytic binding site.
Jessica Dröden, Christoph Globisch, Eliane Landwehr, Theresa S. Braun, Daniel Summerer, Christine Peter, Malte Drescher   +6 more
wiley   +1 more source

Integrating Computational Modelling into the Ecosystem of Cochlear Implantation: Advancing Access to Diagnostics, Decision-Making, and Post-Implantation Outcomes on a Global Scale. [PDF]

J Clin Med
Hanekom T.
europepmc   +1 more source