Results 81 to 90 of about 1,181,476 (312)

Functional Hydrogel for Modulating Lipid Droplets and Neuroinflammation in Head Injury

open access: yesAdvanced Functional Materials, EarlyView.
After TBI, elevated cholesterol levels in activated microglia lead to the accumulation of cholesterol esters in lipid droplets, exacerbating neuroinflammation. A β‐cyclodextrin‐conjugated GelMA (βCD‐GelMA) hydrogel is developed to promotes cholesterol efflux and reduces LDL influx, thereby alleviating intracellular cholesterol and lipid droplet buildup.
Feixiang Chen   +9 more
wiley   +1 more source

Impact of Biophysical Mechanisms on Urban Heat Island Associated with Climate Variation and Urban Morphology

open access: yesScientific Reports, 2019
The rapid development of urban areas can potentially alter hydro-meteorological fluxes and lead to the Urban Heat Island (UHI) phenomenon. In this study, UHI intensity and its driving factors were estimated using the Community Land Model (CLM) in cities ...
Ressy Fitria   +3 more
semanticscholar   +1 more source

Toward G-Quadruplex-Based Anticancer Agents: Biophysical and Biological Studies of Novel AS1411 Derivatives

open access: yesInternational Journal of Molecular Sciences, 2020
Certain G-quadruplex forming guanine-rich oligonucleotides (GROs), including AS1411, are endowed with cancer-selective antiproliferative activity. They are known to bind to nucleolin protein, resulting in the inhibition of nucleolin-mediated phenomena ...
A. Ogloblina   +9 more
semanticscholar   +1 more source

Exploiting Nonlinear Recurrence and Fractal Scaling Properties for Voice Disorder Detection

open access: yesBioMedical Engineering OnLine, 2007
Background Voice disorders affect patients profoundly, and acoustic tools can potentially measure voice function objectively. Disordered sustained vowels exhibit wide-ranging phenomena, from nearly periodic to highly complex, aperiodic vibrations, and ...
Roberts Stephen J   +4 more
doaj   +1 more source

Web-based computational chemistry education with CHARMMing II: Coarse-grained protein folding. [PDF]

open access: yesPLoS Computational Biology, 2014
A lesson utilizing a coarse-grained (CG) Gō-like model has been implemented into the CHARMM INterface and Graphics (CHARMMing) web portal (www.charmming.org) to the Chemistry at HARvard Macromolecular Mechanics (CHARMM) molecular simulation package ...
Frank C Pickard   +5 more
doaj   +1 more source

Probing Early Particle‐Cell Membrane Interactions via Single‐Cell and Single‐Particle Interaction Analysis

open access: yesAdvanced Functional Materials, EarlyView.
The pre‐internalization phase of endocytosis remains poorly characterized at single‐cell levels. Single‐cell pre‐internalization mechanics are investigated using advanced robotic techniques. Cancer cells exhibit biphasic adhesion – rapid initial binding followed by reinforcement – while fibroblasts show gradual engagement.
Houari Bettahar   +6 more
wiley   +1 more source

Food Physical Chemistry and Biophysical Chemistry [PDF]

open access: yes, 2011
Food Physical Chemistry is considered to be a branch of Food Chemistry^1,2^ concerned with the study of both physical and chemical interactions in foods in terms of physical and chemical principles applied to food systems, as well as the applications of ...
I.C. Baianu
core   +1 more source

Extension of a multiphase tumour growth model to study nanoparticle delivery to solid tumours.

open access: yesPLoS ONE, 2020
One of the main challenges in increasing the efficacy of conventional chemotherapeutics is the fact that they do not reach cancerous cells at a sufficiently high dosage.
Barbara Wirthl   +3 more
doaj   +1 more source

Long-term potentiation mechanism of biological postsynaptic activity in neuro-inspired halide perovskite memristors

open access: yesNeuromorphic Computing and Engineering, 2023
Perovskite memristors have emerged as leading contenders in brain-inspired neuromorphic electronics. Although these devices have been shown to accurately reproduce synaptic dynamics, they pose challenges for in-depth understanding of the underlying ...
Enrique Hernández-Balaguera   +6 more
doaj   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

open access: yesAdvanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu   +7 more
wiley   +1 more source

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