Automation and Active Learning for the Multi‐Objective Optimization of Antibody Formulations
Advanced Science, EarlyView.Successful antibody formulation necessitates balancing factors such as thermal stability, colloidal stability, and viscosity across a vast excipient design space. This work integrates robotic liquid handling, high‐throughput biophysical characterization, and multi‐objective Bayesian optimization in an iterative closed‐loop Design‐Build‐Test‐Learn cycle.
D. Christopher Radford +3 more
wiley +1 more source
Correction: Modifying recombinant purple acid phosphatase using computational design. [PDF]
Eur Biophys JVenkatramani A +5 more
europepmc +1 more source
Advanced Science, EarlyView.The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt +16 more
wiley +1 more source
Retraction Note: Quantum mechanical justification for induced fit model conformational changes in allosteric enzymes based on the quantum perturbation theory and Davydov's soliton theory. [PDF]
J Biol PhysFaeznia F.
europepmc +1 more source
Journal of Medical Physics and Biophysics: the Inaugural Issue [PDF]
, 2014 Pawiro, Supriyanto Ardjo; Medical Physics and Biophysics Division, Department of Physics, Faculty of Mathematics and Natural Sciences, University of Indonesia
core
Advanced Science, EarlyView.DDSurfer reconstructs cortical surfaces directly from diffusion MRI without requiring T1‐weighted scans. By fusing complementary microstructural features and learning diffeomorphic deformations, it efficiently generates accurate white matter and pial surfaces, improving geometric fidelity and morphometric reliability across datasets for robust surface ...
Chengjin Li +10 more
wiley +1 more source
Editorial: Methodological advancements and improvements in structural biology
Frontiers in Molecular BiosciencesAnnalisa Pastore +2 more
doaj +1 more source
Correction to: Accuracy of vestibular schwannoma segmentation using deep learning models - a systematic review & meta-analysis. [PDF]
NeuroradiologyŁajczak P +3 more
europepmc +1 more source
Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo‐Electron Tomography
Advanced Science, EarlyView.Correlative cryo‐electron tomography in primary cortical neurons and NIID mouse brain tissue reveals that polyG inclusions are interconnected ribbon‐like assemblies rather than canonical amyloid fibrils. Multiple compartment‐specific ribbon states show distinct 26S proteasome accessibility, while cytoplasmic ribbons contact and deform ER‐like ...
Yunwen Qian +12 more
wiley +1 more source
Correction: APOE4-Expressing Astrocytes Exhibit Parkinson's Disease-Related Pathology. [PDF]
Mol NeurobiolNechushtai L +5 more
europepmc +1 more source