Results 1 to 10 of about 5,504,723 (310)

Capturing protein communities by structural proteomics in a thermophilic eukaryote

Molecular Systems Biology, 2017
The arrangement of proteins into complexes is a key organizational principle for many cellular functions. Although the topology of many complexes has been systematically analyzed in isolation, their molecular sociology in situ remains elusive.
Panagiotis L Kastritis, Francis J O'Reilly, Thomas Bock, Yuanyue Li, Matt Z Rogon, Katarzyna Buczak, Natalie Romanov, Matthew J Betts, Khanh Huy Bui, Wim J Hagen, Marco L Hennrich, Marie‐Therese Mackmull, Juri Rappsilber, Robert B Russell, Peer Bork, Martin Beck, Anne‐Claude Gavin   +16 more
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Melatonin Reduces Oxidative Stress and Cardiovascular Changes Induced by Stanozolol in Rats Exposed to Swimming Exercise

Eurasian Journal of Medicine, 2019
Objective: Anabolic-androgenic steroids (AAS) are nominated for clinical use to promote protein synthesis in many therapeutic conditions. However, the indiscriminate use of AAS is related to hazardous cardiac disturbances and oxidative stress.
Gustavo Barbosa dos Santos, Marcelo José Machado Rodrigues, Estela Maria Gonçalves, Maria Cristina Cintra Gomes Marcondes, Miguel Arcanjo Areas   +4 more
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Variable microtubule architecture in the malaria parasite

Nature Communications, 2023
Microtubules are a ubiquitous eukaryotic cytoskeletal element typically consisting of 13 protofilaments arranged in a hollow cylinder. Using CryoEM and subvolume averaging, Ferreira and Pražák et al.
Josie L. Ferreira, Vojtěch Pražák, Daven Vasishtan, Marc Siggel, Franziska Hentzschel, Annika M. Binder, Emma Pietsch, Jan Kosinski, Friedrich Frischknecht, Tim W. Gilberger, Kay Grünewald   +10 more
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An atlas of novel microtubule-associated proteins in the malaria parasite Plasmodium falciparum

mBio
Mature gametocytes of Plasmodium falciparum exhibit a characteristic falciform shape, which is conferred by a complex array of subpellicular microtubules (SPMTs) associated with the inner membrane complex (IMC).
Korbinian Niedermüller, Nick Piwon, Joëlle Paolo Mesen-Ramirez, Leah Zink, Sarah Lemcke, Benjamin Liffner, Cláudia F. Fernandes, Guilherme B. Farias, Arne Alder, Christian Löw, Noa Dahan, Danny W. Wilson, José Cubillán-Marín, Tim W. Gilberger   +13 more
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Subspecies in the global human gut microbiome

Molecular Systems Biology, 2017
Population genomics of prokaryotes has been studied in depth in only a small number of primarily pathogenic bacteria, as genome sequences of isolates of diverse origin are lacking for most species.
Paul I Costea, Luis Pedro Coelho, Shinichi Sunagawa, Robin Munch, Jaime Huerta‐Cepas, Kristoffer Forslund, Falk Hildebrand, Almagul Kushugulova, Georg Zeller, Peer Bork   +9 more
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Structural basis of BAK activation in mitochondrial apoptosis initiation

Nature Communications, 2022
The authors show that the mechanism of BAK activation in mitochondrial apoptosis involves cooperation between direct activation by BH3-only protein BID and BAK autoactivation, providing a unifying basis for BAK triggering by BH3 ligands.
Geetika Singh, Cristina D. Guibao, Jayaraman Seetharaman, Anup Aggarwal, Christy R. Grace, Dan E. McNamara, Sivaraja Vaithiyalingam, M. Brett Waddell, Tudor Moldoveanu   +8 more
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Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing protein

Nature Communications, 2021
Alpha-1-antitrypsin (AAT) deficiency results from misfolding-prone AAT variants. Here the authors show that AAT forms co-translational folding intermediates on the ribosome that persist upon release and determine its folding fate.
Elena Plessa, Lien P. Chu, Sammy H. S. Chan, Oliver L. Thomas, Anaïs M. E. Cassaignau, Christopher A. Waudby, John Christodoulou, Lisa D. Cabrita   +7 more
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Molecular insight into RNA polymerase I promoter recognition and promoter melting

Nature Communications, 2019
RNA polymerase I (Pol I) catalyses the transcription of pre-ribosomal RNA and for transcription initiation Pol I assembles with core factor and Rrn3 on the rDNA core promoter.
Yashar Sadian, Florence Baudin, Lucas Tafur, Brice Murciano, Rene Wetzel, Felix Weis, Christoph W. Müller   +6 more
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Molecular basis of TASL recruitment by the peptide/histidine transporter 1, PHT1

Nature Communications, 2023
PHT1 is a histidine /oligopeptide transporter with an essential role in Toll-like receptor innate immune responses. It can act as a receptor by recruiting the adaptor protein TASL which leads to type I interferon production via IRF5.
Tânia F. Custódio, Maxime Killer, Dingquan Yu, Virginia Puente, Daniel P. Teufel, Alexander Pautsch, Gisela Schnapp, Marc Grundl, Jan Kosinski, Christian Löw   +9 more
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A modular platform for automated cryo-FIB workflows

eLife, 2021
Lamella micromachining by focused ion beam milling at cryogenic temperature (cryo-FIB) has matured into a preparation method widely used for cellular cryo-electron tomography.
Sven Klumpe, Herman KH Fung, Sara K Goetz, Ievgeniia Zagoriy, Bernhard Hampoelz, Xiaojie Zhang, Philipp S Erdmann, Janina Baumbach, Christoph W Müller, Martin Beck, Jürgen M Plitzko, Julia Mahamid   +11 more
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