Results 21 to 30 of about 893,788 (266)

Capturing protein communities by structural proteomics in a thermophilic eukaryote

Molecular Systems Biology, 2017
The arrangement of proteins into complexes is a key organizational principle for many cellular functions. Although the topology of many complexes has been systematically analyzed in isolation, their molecular sociology in situ remains elusive.
Panagiotis L Kastritis, Francis J O'Reilly, Thomas Bock, Yuanyue Li, Matt Z Rogon, Katarzyna Buczak, Natalie Romanov, Matthew J Betts, Khanh Huy Bui, Wim J Hagen, Marco L Hennrich, Marie‐Therese Mackmull, Juri Rappsilber, Robert B Russell, Peer Bork, Martin Beck, Anne‐Claude Gavin   +16 more
doaj   +1 more source

Melatonin Reduces Oxidative Stress and Cardiovascular Changes Induced by Stanozolol in Rats Exposed to Swimming Exercise

Eurasian Journal of Medicine, 2019
Objective: Anabolic-androgenic steroids (AAS) are nominated for clinical use to promote protein synthesis in many therapeutic conditions. However, the indiscriminate use of AAS is related to hazardous cardiac disturbances and oxidative stress.
Gustavo Barbosa dos Santos, Marcelo José Machado Rodrigues, Estela Maria Gonçalves, Maria Cristina Cintra Gomes Marcondes, Miguel Arcanjo Areas   +4 more
doaj   +1 more source

Structure of the TFIIIC subcomplex τA provides insights into RNA polymerase III pre-initiation complex formation

Nature Communications, 2020
Transcription factor TFIIIC plays roles in Pol III transcription and in chromatin organization. CryoEM structure of the yeast TFIIIC subcomplex τA, a negative stain reconstruction of τA bound to the TFIIIB subunits Brf1 and TBP and accompanying ...
Matthias K. Vorländer, Anna Jungblut, Kai Karius, Florence Baudin, Helga Grötsch, Jan Kosinski, Christoph W. Müller   +6 more
doaj   +1 more source

An atlas of novel microtubule-associated proteins in the malaria parasite Plasmodium falciparum

mBio
Mature gametocytes of Plasmodium falciparum exhibit a characteristic falciform shape, which is conferred by a complex array of subpellicular microtubules (SPMTs) associated with the inner membrane complex (IMC).
Korbinian Niedermüller, Nick Piwon, Joëlle Paolo Mesen-Ramirez, Leah Zink, Sarah Lemcke, Benjamin Liffner, Cláudia F. Fernandes, Guilherme B. Farias, Arne Alder, Christian Löw, Noa Dahan, Danny W. Wilson, José Cubillán-Marín, Tim W. Gilberger   +13 more
doaj   +1 more source

Subspecies in the global human gut microbiome

Molecular Systems Biology, 2017
Population genomics of prokaryotes has been studied in depth in only a small number of primarily pathogenic bacteria, as genome sequences of isolates of diverse origin are lacking for most species.
Paul I Costea, Luis Pedro Coelho, Shinichi Sunagawa, Robin Munch, Jaime Huerta‐Cepas, Kristoffer Forslund, Falk Hildebrand, Almagul Kushugulova, Georg Zeller, Peer Bork   +9 more
doaj   +1 more source

Structural basis of BAK activation in mitochondrial apoptosis initiation

Nature Communications, 2022
The authors show that the mechanism of BAK activation in mitochondrial apoptosis involves cooperation between direct activation by BH3-only protein BID and BAK autoactivation, providing a unifying basis for BAK triggering by BH3 ligands.
Geetika Singh, Cristina D. Guibao, Jayaraman Seetharaman, Anup Aggarwal, Christy R. Grace, Dan E. McNamara, Sivaraja Vaithiyalingam, M. Brett Waddell, Tudor Moldoveanu   +8 more
doaj   +1 more source

Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing protein

Nature Communications, 2021
Alpha-1-antitrypsin (AAT) deficiency results from misfolding-prone AAT variants. Here the authors show that AAT forms co-translational folding intermediates on the ribosome that persist upon release and determine its folding fate.
Elena Plessa, Lien P. Chu, Sammy H. S. Chan, Oliver L. Thomas, Anaïs M. E. Cassaignau, Christopher A. Waudby, John Christodoulou, Lisa D. Cabrita   +7 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Molecular basis of TASL recruitment by the peptide/histidine transporter 1, PHT1

Nature Communications, 2023
PHT1 is a histidine /oligopeptide transporter with an essential role in Toll-like receptor innate immune responses. It can act as a receptor by recruiting the adaptor protein TASL which leads to type I interferon production via IRF5.
Tânia F. Custódio, Maxime Killer, Dingquan Yu, Virginia Puente, Daniel P. Teufel, Alexander Pautsch, Gisela Schnapp, Marc Grundl, Jan Kosinski, Christian Löw   +9 more
doaj   +1 more source