Results 21 to 30 of about 5,504,723 (310)

A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations

eLife, 2020
Synaptojanin1 (Synj1) is a phosphoinositide phosphatase, important in clathrin uncoating during endocytosis of presynaptic vesicles. It was identified as a potential drug target for Alzheimer’s disease, Down syndrome, and TBC1D24-associated epilepsy ...
Jone Paesmans, Ella Martin, Babette Deckers, Marjolijn Berghmans, Ritika Sethi, Yannick Loeys, Els Pardon, Jan Steyaert, Patrik Verstreken, Christian Galicia, Wim Versées   +10 more
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Structural Biology of Telomerase [PDF]

Cold Spring Harbor Perspectives in Biology, 2019
Telomerase is a DNA polymerase that extends the 3' ends of chromosomes by processively synthesizing multiple telomeric repeats. It is a unique ribonucleoprotein (RNP) containing a specialized telomerase reverse transcriptase (TERT) and telomerase RNA (TER) with its own template and other elements required with TERT for activity (catalytic core), as ...
Yaqiang Wang, Lukas Sušac, Juli Feigon
openaire   +4 more sources

A systematic screen for protein–lipid interactions in Saccharomyces cerevisiae

Molecular Systems Biology, 2010
Protein–metabolite networks are central to biological systems, but are incompletely understood. Here, we report a screen to catalog protein–lipid interactions in yeast.
Oriol Gallego, Matthew J Betts, Jelena Gvozdenovic‐Jeremic, Kenji Maeda, Christian Matetzki, Carmen Aguilar‐Gurrieri, Pedro Beltran‐Alvarez, Stefan Bonn, Carlos Fernández‐Tornero, Lars Juhl Jensen, Michael Kuhn, Jamie Trott, Vladimir Rybin, Christoph W Müller, Peer Bork, Marko Kaksonen, Robert B Russell, Anne‐Claude Gavin   +17 more
doaj   +1 more source

Structural Biology of the Proteasome [PDF]

Annual Review of Biophysics, 2013
The proteasome refers to a collection of complexes centered on the 20S proteasome core particle (20S CP), a complex of 28 subunits that houses proteolytic sites in its hollow interior. Proteasomes are found in eukaryotes, archaea, and some eubacteria, and their activity is critical for many cellular pathways.
Erik, Kish-Trier, Christopher P, Hill
openaire   +2 more sources

The Scottish Structural Proteomics Facility : targets, methods and outputs [PDF]

, 2010
The Scottish Structural Proteomics Facility was funded to develop a laboratory scale approach to high throughput structure determination. The effort was successful in that over 40 structures were determined.
Garrett, Roger A., Barton, Geoffrey J, Mark Dorward (10196177), Prangishvili, D, Muse Oke (452182), Schwarz-Linek, Ulrich, Xu Peng, Melina Kerou (6987863), Catherine H Botting (16216415), James H Naismith (16216433), Prangishvili, D. A., Prakash Patel (594463), David T F Dryden (16216421), Johannes van Niekerk, C. A., C A Johannes van Niekerk (16216409), Carter, Lester G., Taylor, Garry L, Md Arif Sheikh (16216349), Dorward, M, Michal Zawadzki, McMahon, Stephen A., Sheikh, Md Arif, Kerou, Melina, Challis, GL, Muse Oke, Carter, LG, Weikart, Nadine D., James H. Naismith, Oke, M, Challis, Gregory L, McMahon, Stephen A, Yan, X, Malcolm F. White, Xuan Yan (4844139), Liu, Huanting, Melina Kerou, Weikart, Nadine D, van Niekerk, CA, Peter J. Coote, Botting, Catherine H., Michal Zawadzki (11327080), Taylor, GL, David T. F. Dryden, Nadia Kadi (2425486), Prangishvili, David, Sheikh, Md. Arif, Naismith, JH, Schwarz-Linek, Uli, Yan, Xuan, Ulrich Schwarz-Linek, Kadi, N, Coote, Peter J., White, MF, Stephen A. McMahon, Weikart, ND, Carter, Lester G, Kenneth A Johnson (16216388), White, Malcolm F., Overton, IM, Garrett, Roger A, Schmelz, Stefan, Mark Dorward, Kadi, Nadia, Nadia Kadi, Naismith, James H., Liu, H, Garry L Taylor (16216352), Dryden, DT, McMahon, SA, Xuan Yan, Coote, PJ, Niekerk, C. A. Johannes, Lester G. Carter, Zawadzki, M, Overton, Ian M.; id_orcid, Gregory L. Challis, Geoffrey J Barton (16216424), Gregory L Challis (16216427), Ian M Overton (16216406), White, Malcolm F, Lester G Carter (16208402), Stephen A McMahon (16216391), van Niekerk, C A Johannes, Dryden, David T F, Falconer, Helen, Cozens, Christopher, Patel, Prakash, Geoffrey J. Barton, Md. Arif Sheikh, Peng, X, Botting, Catherine H, Barton, Geoffrey J; id_orcid, Roger A Garrett (16216412), Ulrich Schwarz-Linek (5801099), Johnson, KA, Falconer, H, Dorward, Mark, Barton, Geoffrey J., Xu Peng (365714), Huanting Liu (3691537), Peng, Xu, Sheikh, MA, Oke, Muse, Powers, H, Helen Falconer, Nadine D. Weikart, Dryden, David T. F., Prakash Patel, Powers, Helen, Naismith, James H, Malcolm F White (16216430), Kenneth A. Johnson, Taylor, Garry L., Overton, Ian M., Schmelz, S, Catherine H. Botting, Helen Falconer (16216400), Coote, Peter J, Johnson, Kenneth A, Botting, CH, Stefan Schmelz, Kerou, M, Barton, GJ, David Prangishvili (22095), Johnson, Kenneth A., Zawadzki, Michal, Christopher Cozens, David Prangishvili, Nadine D Weikart (16216394), C. A. Johannes van Niekerk, Overton, Ian M, Christopher Cozens (5232944), Garrett, Roger Antony, Peter J Coote (16216418), Challis, Gregory L., Ian M. Overton, Roger A. Garrett, Garrett, RA, Cozens, C, Garry L. Taylor, Helen Powers (16216403), Stefan Schmelz (16216397), Helen Powers, Huanting Liu, Patel, P   +144 more
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Ribosomal Antibiotics: Contemporary Challenges

Antibiotics, 2016
Most ribosomal antibiotics obstruct distinct ribosomal functions. In selected cases, in addition to paralyzing vital ribosomal tasks, some ribosomal antibiotics are involved in cellular regulation.
Tamar Auerbach-Nevo, David Baram, Anat Bashan, Matthew Belousoff, Elinor Breiner, Chen Davidovich, Giuseppe Cimicata, Zohar Eyal, Yehuda Halfon, Miri Krupkin, Donna Matzov, Markus Metz, Mruwat Rufayda, Moshe Peretz, Ophir Pick, Erez Pyetan, Haim Rozenberg, Moran Shalev-Benami, Itai Wekselman, Raz Zarivach, Ella Zimmerman, Nofar Assis, Joel Bloch, Hadar Israeli, Rinat Kalaora, Lisha Lim, Ofir Sade-Falk, Tal Shapira, Leena Taha-Salaime, Hua Tang, Ada Yonath   +30 more
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Microfluidic Technologies for Structural Biology [PDF]

, 2004
In the post-genomic era, X-ray crystallography has emerged as the workhorse of large-scale structural biology initiatives that seek to understand protein function and interaction at the atomic scale.
Hansen, Carl Lars Genghis
core   +1 more source

The application of helix fusion methods in structural biology

, 2020
Methods generating fusion proteins with rigid and predictable structures have been developed in recent years. Among them, helix fusion methods that link two proteins by connecting their terminal alpha helices into a single and extended alpha helix can be
Kim, Youngjin, Lee, Jie-Oh, Kwon, Na-Young   +2 more
core   +1 more source

Structural insights into the dynamics and function of the C-terminus of the E. coli RNA chaperone Hfq [PDF]

, 2011
The hexameric Escherichia coli RNA chaperone Hfq (Hfq(Ec)) is involved in riboregulation of target mRNAs by small trans-encoded RNAs. Hfq proteins of different bacteria comprise an evolutionarily conserved core, whereas the C-terminus is variable in ...
Beich-Frandsen, Mads (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Kontaxis, Georg (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Blasi, U., Rajkowitsch, L., Miles, Andrew (Birkbeck College), Sjöblom, Björn (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Miles, Andrew J., Svergun, D.I., Kloiber, K., Kristina Djinović-Carugo, Vecerek, B., Karin Kloiber, Konarev, P.V., Lukas Rajkowitsch, Hämmerle, Hermann Konrad (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna), Georg Kontaxis, Bläsi, Udo (Department of Microbiology, Immunobiology and Genetics, Centre for Molecular Biology, University of Vienna), Djinovic-Carugo, K., Robert Konrat, Branislav Večerek, Konarev, Peter V. (EMBL Hamburg), Andrew J. Miles, Kloiber, Karin (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Rajkowitsch, Lukas (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna), Udo Bläsi, Wallace, Bonnie A., Svergun, D. I., Petr V. Konarev, Svergun, Dimitri I. (EMBL Hamburg), Björn Sjöblom, Hammerle, H., Mads Beich-Frandsen, Wallace, B. A., Sjoblom, B., Miles, A. J., Konrat, Robert (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Vecerek, Branislav (Department of Microbiology, Immunobiology and Genetics, Centre for Molecular Biology, University of Vienna), Dimitri I. Svergun, B. A. Wallace, Beich Frandsen, M., Djinovic Carugo, K., Konarev, P. V., Beich-Frandsen, M., Konrat, R., Djinovic-Carugo, Kristina (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Hermann Hämmerle, Kontaxis, G.   +46 more
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Hands-on training in structural biology, a tool for sustainable development in Africa series 4. [PDF]

, 2022
Structural biology is an essential tool for understanding the molecular basis of diseases, which can guide the rational design of new drugs, vaccines, and the optimisation of existing medicines.

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