Results 21 to 30 of about 899,634 (266)
Capturing protein communities by structural proteomics in a thermophilic eukaryote
Molecular Systems Biology, 2017 The arrangement of proteins into complexes is a key organizational principle for many cellular functions. Although the topology of many complexes has been systematically analyzed in isolation, their molecular sociology in situ remains elusive.
Panagiotis L Kastritis +16 more
doaj +1 more source
Eurasian Journal of Medicine, 2019 Objective: Anabolic-androgenic steroids (AAS) are nominated for clinical use to promote protein synthesis in many therapeutic conditions. However, the indiscriminate use of AAS is related to hazardous cardiac disturbances and oxidative stress.
Gustavo Barbosa dos Santos +4 more
doaj +1 more source
Structural analysis and architectural principles of the bacterial amyloid curli
Nature Communications, 2023 Two decades have passed since the initial proposition that amyloids are not only (toxic) byproducts of an unintended aggregation cascade, but that they can also be produced by an organism to serve a defined biological function.
Mike Sleutel +3 more
doaj +1 more source
An atlas of novel microtubule-associated proteins in the malaria parasite Plasmodium falciparum
mBioMature gametocytes of Plasmodium falciparum exhibit a characteristic falciform shape, which is conferred by a complex array of subpellicular microtubules (SPMTs) associated with the inner membrane complex (IMC).
Korbinian Niedermüller +13 more
doaj +1 more source
Subspecies in the global human gut microbiome
Molecular Systems Biology, 2017 Population genomics of prokaryotes has been studied in depth in only a small number of primarily pathogenic bacteria, as genome sequences of isolates of diverse origin are lacking for most species.
Paul I Costea +9 more
doaj +1 more source
Structural basis of BAK activation in mitochondrial apoptosis initiation
Nature Communications, 2022 The authors show that the mechanism of BAK activation in mitochondrial apoptosis involves cooperation between direct activation by BH3-only protein BID and BAK autoactivation, providing a unifying basis for BAK triggering by BH3 ligands.
Geetika Singh +8 more
doaj +1 more source
Polyproteins in structural biology
Current Opinion in Structural Biology, 2015 Polyproteins are chains of covalently conjoined smaller proteins that occur in nature as versatile means to organize the proteome of viruses including HIV. During maturation, viral polyproteins are typically cleaved into the constituent proteins with different biological functions by highly specific proteases, and structural analyses at defined stages ...
Crépin, Thibaut +5 more
openaire +4 more sources
Early Impact of Childhood Opportunity on Neurocognitive Outcomes in Sickle Cell Disease
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Neurocognitive impairment is a well‐recognized complication of sickle cell disease (SCD) that begins early in childhood and persists across development. While cerebrovascular injury contributes substantially to risk, neurocognitive deficits are also observed in children without overt or silent cerebral infarctions, suggesting ...
Julia E. LaMotte +5 more
wiley +1 more source
Molecular insight into RNA polymerase I promoter recognition and promoter melting
Nature Communications, 2019 RNA polymerase I (Pol I) catalyses the transcription of pre-ribosomal RNA and for transcription initiation Pol I assembles with core factor and Rrn3 on the rDNA core promoter.
Yashar Sadian +6 more
doaj +1 more source
Nature Communications, 2021 Alpha-1-antitrypsin (AAT) deficiency results from misfolding-prone AAT variants. Here the authors show that AAT forms co-translational folding intermediates on the ribosome that persist upon release and determine its folding fate.
Elena Plessa +7 more
doaj +1 more source