Results 41 to 50 of about 899,634 (266)

Toward molecular trait‐based ecology through integration of biogeochemical, geographical and metagenomic data

Molecular Systems Biology, 2011
Using metagenomic ‘parts lists’ to infer global patterns on microbial ecology remains a significant challenge. To deduce important ecological indicators such as environmental adaptation, molecular trait dispersal, diversity variation and primary ...
Jeroen Raes, Ivica Letunic, Takuji Yamada, Lars Juhl Jensen, Peer Bork   +4 more
doaj   +1 more source

Structural biology of an organ

Cell Reports, 2023
Su et al.1 use a build-and-retrieve approach to both identify and determine structures of ten macromolecular machines in the human liver. The authors' method will launch researchers forward in understanding the structural biology of the cell (or organ).
openaire   +3 more sources

Structural Biology for Virus Research [PDF]

Frontiers in Microbiology, 2012
Viruses are strictly dependent on target host cells for their amplification. However, each virus has a unique strategy at each replication step, beginning with entry into the cell, followed by transcription, translation, assembly of viral genome/proteins, and finishing with the cellular release of progeny virions.
Miyazaki, Yasuyuki, Fujita, Mikako, Nomaguchi, Masako, Adachi, Akio   +3 more
openaire   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Disulfide-constrained Fabs overcome target size limitation for high-resolution single particle cryoEM

Nature Communications
High-resolution protein structures are essential for understanding biological mechanisms and drug discovery. While cryoEM has revolutionized structure determination of large protein complexes, most disease-related proteins are small (
Jennifer E. Kung, Matthew C. Johnson, Dimitry Tegunov, Christine C. Jao, Ping Wu, Angela Oh, May Lin, Jose M. Daria, Christopher M. Koth, Christopher P. Arthur, Alexis Rohou, Jawahar Sudhamsu   +11 more
doaj   +1 more source

Quantification of Intrinsically Disordered Proteins: A Problem Not Fully Appreciated

Frontiers in Molecular Biosciences, 2018
Protein quantification is essential in a great variety of biochemical assays, yet the inherent systematic errors associated with the concentration determination of intrinsically disordered proteins (IDPs) using classical methods are hardly appreciated ...
Sara Contreras-Martos, Sara Contreras-Martos, Hung H. Nguyen, Hung H. Nguyen, Phuong N. Nguyen, Phuong N. Nguyen, Nevena Hristozova, Nevena Hristozova, Mauricio Macossay-Castillo, Mauricio Macossay-Castillo, Denes Kovacs, Denes Kovacs, Angela Bekesi, Angela Bekesi, Jesper S. Oemig, Jesper S. Oemig, Dominique Maes, Kris Pauwels, Kris Pauwels, Peter Tompa, Peter Tompa, Peter Tompa, Pierre Lebrun, Pierre Lebrun   +23 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions

Nature Communications, 2020
Although transcription factor (TF) cooperativity is widespread, a global mechanistic understanding of the role of TF cooperativity is still lacking. Here the authors introduce a statistical learning framework that provides structural insight into TF ...
Ignacio L. Ibarra, Nele M. Hollmann, Bernd Klaus, Sandra Augsten, Britta Velten, Janosch Hennig, Judith B. Zaugg   +6 more
doaj   +1 more source

OffsampleAI: artificial intelligence approach to recognize off-sample mass spectrometry images

BMC Bioinformatics, 2020
Background Imaging mass spectrometry (imaging MS) is an enabling technology for spatial metabolomics of tissue sections with rapidly growing areas of applications in biology and medicine.
Katja Ovchinnikova, Vitaly Kovalev, Lachlan Stuart, Theodore Alexandrov   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source