Results 41 to 50 of about 1,927,181 (199)
4D electron imaging: principles and perspectives [PDF]
, 2008 In this perspective we highlight developments and concepts in the field of 4D electron imaging. With spatial and temporal resolutions reaching the picometer and femtosecond, respectively, the field is now embracing ultrafast electron diffraction ...
Shorokhov, Dmitry, Zewail, Ahmed H.
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Molecular insight into RNA polymerase I promoter recognition and promoter melting
Nature Communications, 2019 RNA polymerase I (Pol I) catalyses the transcription of pre-ribosomal RNA and for transcription initiation Pol I assembles with core factor and Rrn3 on the rDNA core promoter.
Yashar Sadian +6 more
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A modular platform for automated cryo-FIB workflows
eLife, 2021 Lamella micromachining by focused ion beam milling at cryogenic temperature (cryo-FIB) has matured into a preparation method widely used for cellular cryo-electron tomography.
Sven Klumpe +11 more
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Semi-algebraic geometry of common lines [PDF]
, 2014 Cryo-electron microscopy is a technique in structural biology for discovering/determining the 3D structure of small molecules. A key step in this process is detecting common lines of intersection between unknown embedded image planes.
Dynerman, David
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A side effect resource to capture phenotypic effects of drugs
Molecular Systems Biology, 2010 The molecular understanding of phenotypes caused by drugs in humans is essential for elucidating mechanisms of action and for developing personalized medicines. Side effects of drugs (also known as adverse drug reactions) are an important source of human
Michael Kuhn +4 more
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iScience, 2022 Summary: During meiosis, programmed DNA double-strand breaks (DSBs) are repaired by homologous recombination. DMC1, a conserved recombinase, plays a central role in this process.
Veronika Altmannova +9 more
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Structural biology of laminins [PDF]
Essays in Biochemistry, 2019 Abstract Laminins are large cell-adhesive glycoproteins that are required for the formation and function of basement membranes in all animals. Structural studies by electron microscopy in the early 1980s revealed a cross-shaped molecule, which subsequently was shown to consist of three distinct polypeptide chains.
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Molecular Systems Biology, 2011 Using metagenomic ‘parts lists’ to infer global patterns on microbial ecology remains a significant challenge. To deduce important ecological indicators such as environmental adaptation, molecular trait dispersal, diversity variation and primary ...
Jeroen Raes +4 more
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Impact of global structure on diffusive exploration of organelle networks [PDF]
, 2020 We investigate diffusive search on planar networks, motivated by tubular organelle networks in cell biology that contain molecules searching for reaction partners and binding sites.
Brown, Aidan I +2 more
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Quantification of Intrinsically Disordered Proteins: A Problem Not Fully Appreciated
Frontiers in Molecular Biosciences, 2018 Protein quantification is essential in a great variety of biochemical assays, yet the inherent systematic errors associated with the concentration determination of intrinsically disordered proteins (IDPs) using classical methods are hardly appreciated ...
Sara Contreras-Martos +23 more
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