Results 31 to 40 of about 1,927,181 (199)
Subspecies in the global human gut microbiome
Molecular Systems Biology, 2017 Population genomics of prokaryotes has been studied in depth in only a small number of primarily pathogenic bacteria, as genome sequences of isolates of diverse origin are lacking for most species.
Paul I Costea +9 more
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Structural basis of BAK activation in mitochondrial apoptosis initiation
Nature Communications, 2022 The authors show that the mechanism of BAK activation in mitochondrial apoptosis involves cooperation between direct activation by BH3-only protein BID and BAK autoactivation, providing a unifying basis for BAK triggering by BH3 ligands.
Geetika Singh +8 more
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Structural biology: a century-long journey into an unseen world [PDF]
, 2015 © Institute of Materials, Minerals and Mining 2015.When the first atomic structures of salt crystals were determined by the Braggs in 1912–1913, the analytical power of X-ray crystallography was immediately evident. Within a few decades the technique was
Curry, S
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Synthesis of partially O-acetylated N-acetylneuraminic acid using regioselective silyl exchange technology. [PDF]
, 2014 Postglycosylation acetylation of sialic acid imparts unique roles to sialoglycoconjugates in mammalian immune response making structural and functional understanding of these analogues important.
Gervay-Hague, Jacquelyn, Park, Simon S
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Graph Theory and Networks in Biology [PDF]
, 2006 In this paper, we present a survey of the use of graph theoretical techniques in Biology. In particular, we discuss recent work on identifying and modelling the structure of bio-molecular networks, as well as the application of centrality measures to ...
Mason, Oliver, Verwoerd, Mark
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Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approach [PDF]
, 2008 BACKGROUND: Calmodulin is an important multifunctional molecule that regulates the activities of a large number of proteins in the cell. Calcium binding induces conformational transitions in calmodulin that make it specifically active to particular ...
Bates, Declan +4 more
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Nature Communications, 2021 Alpha-1-antitrypsin (AAT) deficiency results from misfolding-prone AAT variants. Here the authors show that AAT forms co-translational folding intermediates on the ribosome that persist upon release and determine its folding fate.
Elena Plessa +7 more
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A comparative study of Gaussian Graphical Model approaches for genomic data [PDF]
, 2011 The inference of networks of dependencies by Gaussian Graphical models on high-throughput data is an open issue in modern molecular biology. In this paper we provide a comparative study of three methods to obtain small sample and high dimension estimates
Ancona, N. +5 more
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Polyproteins in structural biology
Current Opinion in Structural Biology, 2015 Polyproteins are chains of covalently conjoined smaller proteins that occur in nature as versatile means to organize the proteome of viruses including HIV. During maturation, viral polyproteins are typically cleaved into the constituent proteins with different biological functions by highly specific proteases, and structural analyses at defined stages ...
Crépin, Thibaut +5 more
openaire +4 more sources
Molecular basis of TASL recruitment by the peptide/histidine transporter 1, PHT1
Nature Communications, 2023 PHT1 is a histidine /oligopeptide transporter with an essential role in Toll-like receptor innate immune responses. It can act as a receptor by recruiting the adaptor protein TASL which leads to type I interferon production via IRF5.
Tânia F. Custódio +9 more
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