Results 11 to 20 of about 893,788 (266)
Structural biology: A golden era
PLOS Biology, 2023 In the past 2 decades, structural biology has transformed from a single technique used on single proteins to a multimodal integrative approach. Recently, protein structure prediction algorithms have opened new avenues to address challenging biological questions.
Carugo, Oliviero +1 more
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Structural Biology of Telomerase [PDF]
Cold Spring Harbor Perspectives in Biology, 2019 Telomerase is a DNA polymerase that extends the 3' ends of chromosomes by processively synthesizing multiple telomeric repeats. It is a unique ribonucleoprotein (RNP) containing a specialized telomerase reverse transcriptase (TERT) and telomerase RNA (TER) with its own template and other elements required with TERT for activity (catalytic core), as ...
Yaqiang Wang, Lukas Sušac, Juli Feigon
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Structural Biology of the Proteasome [PDF]
Annual Review of Biophysics, 2013 The proteasome refers to a collection of complexes centered on the 20S proteasome core particle (20S CP), a complex of 28 subunits that houses proteolytic sites in its hollow interior. Proteasomes are found in eukaryotes, archaea, and some eubacteria, and their activity is critical for many cellular pathways.
Erik, Kish-Trier, Christopher P, Hill
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Communications Biology, 2022 A cryo-EM structure for the three conformers of coxsackievirus A6 provides insight into the infection process of this enterovirus, which is responsible for numerous cases of hand, foot, and mouth disease.
Carina R. Büttner +3 more
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Molecular Systems Biology, 2013 To understand the structure and function of large molecular machines, accurate knowledge of their stoichiometry is essential. In this study, we developed an integrated targeted proteomics and super‐resolution microscopy approach to determine the absolute
Alessandro Ori +11 more
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Degron masking outlines degronons, co-degrading functional modules in the proteome
Communications Biology, 2022 Systematic bioinformatics analysis of cooperative degradation of protein complexes indicates that degrons extensively overlap with protein-protein interaction sites, hiding degrons from ubiquitination machinery and suggesting the existence of co ...
Mainak Guharoy +3 more
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Structural analysis and architectural principles of the bacterial amyloid curli
Nature Communications, 2023 Two decades have passed since the initial proposition that amyloids are not only (toxic) byproducts of an unintended aggregation cascade, but that they can also be produced by an organism to serve a defined biological function.
Mike Sleutel +3 more
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Dual drug targeting to kill colon cancers
Cancer Medicine, 2022 Introduction Colorectal cancer (CRC) is driven by a small set of oncogenic and tumour suppressor mutations. However, different combinations of mutations often lead to poor tumour responses to individual anticancer drugs.
Silvia Paola Corona +5 more
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Variable microtubule architecture in the malaria parasite
Nature Communications, 2023 Microtubules are a ubiquitous eukaryotic cytoskeletal element typically consisting of 13 protofilaments arranged in a hollow cylinder. Using CryoEM and subvolume averaging, Ferreira and Pražák et al.
Josie L. Ferreira +10 more
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Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1999 Protein crystallography has become a major technique for understanding cellular processes. This has come about through great advances in the technology of data collection and interpretation, particularly the use of synchrotron radiation. The ability to express eukaryotic genes in Escherichia coli is also important ...
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