Results 11 to 20 of about 1,927,181 (199)
Towards molecular systems biology of gene transcription and regulation [PDF]
, 2010 Ten years after the determination of the RNA polymerase 11 structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural
Cramer, Patrick
core +1 more source
The RCSB Protein Data Bank: views of structural biology for basic and applied research and education. [PDF]
, 2014 The RCSB Protein Data Bank (RCSB PDB, http://www.rcsb.org) provides access to 3D structures of biological macromolecules and is one of the leading resources in biology and biomedicine worldwide.
Berman, Helen M +14 more
core +4 more sources
Structural Biology of the Proteasome [PDF]
Annual Review of Biophysics, 2013 The proteasome refers to a collection of complexes centered on the 20S proteasome core particle (20S CP), a complex of 28 subunits that houses proteolytic sites in its hollow interior. Proteasomes are found in eukaryotes, archaea, and some eubacteria, and their activity is critical for many cellular pathways.
Erik, Kish-Trier, Christopher P, Hill
openaire +2 more sources
eLife, 2020 Synaptojanin1 (Synj1) is a phosphoinositide phosphatase, important in clathrin uncoating during endocytosis of presynaptic vesicles. It was identified as a potential drug target for Alzheimer’s disease, Down syndrome, and TBC1D24-associated epilepsy ...
Jone Paesmans +10 more
doaj +1 more source
A systematic screen for protein–lipid interactions in Saccharomyces cerevisiae
Molecular Systems Biology, 2010 Protein–metabolite networks are central to biological systems, but are incompletely understood. Here, we report a screen to catalog protein–lipid interactions in yeast.
Oriol Gallego +17 more
doaj +1 more source
Ribosomal Antibiotics: Contemporary Challenges
Antibiotics, 2016 Most ribosomal antibiotics obstruct distinct ribosomal functions. In selected cases, in addition to paralyzing vital ribosomal tasks, some ribosomal antibiotics are involved in cellular regulation.
Tamar Auerbach-Nevo +30 more
doaj +1 more source
Communications Biology, 2022 A cryo-EM structure for the three conformers of coxsackievirus A6 provides insight into the infection process of this enterovirus, which is responsible for numerous cases of hand, foot, and mouth disease.
Carina R. Büttner +3 more
doaj +1 more source
Molecular Systems Biology, 2013 To understand the structure and function of large molecular machines, accurate knowledge of their stoichiometry is essential. In this study, we developed an integrated targeted proteomics and super‐resolution microscopy approach to determine the absolute
Alessandro Ori +11 more
doaj +1 more source
Degron masking outlines degronons, co-degrading functional modules in the proteome
Communications Biology, 2022 Systematic bioinformatics analysis of cooperative degradation of protein complexes indicates that degrons extensively overlap with protein-protein interaction sites, hiding degrons from ubiquitination machinery and suggesting the existence of co ...
Mainak Guharoy +3 more
doaj +1 more source