Results 11 to 20 of about 5,504,723 (310)
Structural biology: A golden era
PLOS Biology, 2023 In the past 2 decades, structural biology has transformed from a single technique used on single proteins to a multimodal integrative approach. Recently, protein structure prediction algorithms have opened new avenues to address challenging biological questions.
Carugo, Oliviero +1 more
openaire +6 more sources
The Cryo-EM structures of two amphibian antimicrobial cross-β amyloid fibrils
Nature Communications, 2022 In this work the authors provide high-resolution structural support for the amyloid-antimicrobial link via functional amyloids displaying propeller-like and kinked cross-β fibrils.
Robert Bücker +6 more
doaj +1 more source
Evolution of the SARS-CoV-2 spike protein in the human host
Nature Communications, 2022 The SARS-CoV-2 spike has been evolving in the human population. The variants of concern alpha and beta evolved to optimise spike openness and so ability to bind its receptor ACE2, the affinity towards the receptor, and stability upon receptor binding.
Antoni G. Wrobel +8 more
doaj +1 more source
GRaNIE and GRaNPA: inference and evaluation of enhancer‐mediated gene regulatory networks
Molecular Systems Biology, 2023 Enhancers play a vital role in gene regulation and are critical in mediating the impact of noncoding genetic variants associated with complex traits. Enhancer activity is a cell‐type‐specific process regulated by transcription factors (TFs), epigenetic ...
Aryan Kamal +14 more
doaj +1 more source
Nature Communications, 2023 Bacterial multi-step phospho-relays employ receiver domains that act as intermediaries in phosphoryl shuttling. Here, the authors show that such a domain does not experience structural changes upon pseudo-phosphorylation, in contrast to the well-studied ...
Mitchell Brüderlin +5 more
doaj +1 more source
mSphere, 2021 During the symptomatic human blood phase, malaria parasites replicate within red blood cells. Parasite proliferation relies on the uptake of nutrients, such as amino acids, from the host cell and blood plasma, requiring transport across multiple ...
Jan Stephan Wichers +13 more
doaj +1 more source
Structure and function of the EA1 surface layer of Bacillus anthracis
Nature Communications, 2023 The Gram-positive spore-forming bacterium Bacillus anthracis is the causative agent of anthrax, a deadly disease mostly affecting wildlife and livestock, as well as representing a bioterrorism threat. Its cell surface is covered by the mutually exclusive
Adrià Sogues +5 more
doaj +1 more source
Adaptive laboratory evolution of microbial co‐cultures for improved metabolite secretion
Molecular Systems Biology, 2021 Adaptive laboratory evolution has proven highly effective for obtaining microorganisms with enhanced capabilities. Yet, this method is inherently restricted to the traits that are positively linked to cell fitness, such as nutrient utilization.
Dimitrios Konstantinidis +9 more
doaj +1 more source
TarO : a target optimisation system for structural biology [PDF]
, 2008 This work was funded by the UK Biotechnology and Biological Sciences Research Council (BBSRC) Structural Proteomics of Rational Targets (SPoRT) initiative, (Grant BBS/B/14434).
Naismith, Jim +44 more
core +1 more source
Towards molecular systems biology of gene transcription and regulation [PDF]
, 2010 Ten years after the determination of the RNA polymerase 11 structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural
Cramer, P., Cramer, Patrick
core +1 more source