Results 11 to 20 of about 899,634 (266)

A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations

eLife, 2020
Synaptojanin1 (Synj1) is a phosphoinositide phosphatase, important in clathrin uncoating during endocytosis of presynaptic vesicles. It was identified as a potential drug target for Alzheimer’s disease, Down syndrome, and TBC1D24-associated epilepsy ...
Jone Paesmans, Ella Martin, Babette Deckers, Marjolijn Berghmans, Ritika Sethi, Yannick Loeys, Els Pardon, Jan Steyaert, Patrik Verstreken, Christian Galicia, Wim Versées   +10 more
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A systematic screen for protein–lipid interactions in Saccharomyces cerevisiae

Molecular Systems Biology, 2010
Protein–metabolite networks are central to biological systems, but are incompletely understood. Here, we report a screen to catalog protein–lipid interactions in yeast.
Oriol Gallego, Matthew J Betts, Jelena Gvozdenovic‐Jeremic, Kenji Maeda, Christian Matetzki, Carmen Aguilar‐Gurrieri, Pedro Beltran‐Alvarez, Stefan Bonn, Carlos Fernández‐Tornero, Lars Juhl Jensen, Michael Kuhn, Jamie Trott, Vladimir Rybin, Christoph W Müller, Peer Bork, Marko Kaksonen, Robert B Russell, Anne‐Claude Gavin   +17 more
doaj   +1 more source

Ribosomal Antibiotics: Contemporary Challenges

Antibiotics, 2016
Most ribosomal antibiotics obstruct distinct ribosomal functions. In selected cases, in addition to paralyzing vital ribosomal tasks, some ribosomal antibiotics are involved in cellular regulation.
Tamar Auerbach-Nevo, David Baram, Anat Bashan, Matthew Belousoff, Elinor Breiner, Chen Davidovich, Giuseppe Cimicata, Zohar Eyal, Yehuda Halfon, Miri Krupkin, Donna Matzov, Markus Metz, Mruwat Rufayda, Moshe Peretz, Ophir Pick, Erez Pyetan, Haim Rozenberg, Moran Shalev-Benami, Itai Wekselman, Raz Zarivach, Ella Zimmerman, Nofar Assis, Joel Bloch, Hadar Israeli, Rinat Kalaora, Lisha Lim, Ofir Sade-Falk, Tal Shapira, Leena Taha-Salaime, Hua Tang, Ada Yonath   +30 more
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Cryo-electron microscopy and image classification reveal the existence and structure of the coxsackievirus A6 virion

Communications Biology, 2022
A cryo-EM structure for the three conformers of coxsackievirus A6 provides insight into the infection process of this enterovirus, which is responsible for numerous cases of hand, foot, and mouth disease.
Carina R. Büttner, Radovan Spurný, Tibor Füzik, Pavel Plevka   +3 more
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Cell type‐specific nuclear pores: a case in point for context‐dependent stoichiometry of molecular machines

Molecular Systems Biology, 2013
To understand the structure and function of large molecular machines, accurate knowledge of their stoichiometry is essential. In this study, we developed an integrated targeted proteomics and super‐resolution microscopy approach to determine the absolute
Alessandro Ori, Niccolò Banterle, Murat Iskar, Amparo Andrés‐Pons, Claudia Escher, Huy Khanh Bui, Lenore Sparks, Victor Solis‐Mezarino, Oliver Rinner, Peer Bork, Edward A Lemke, Martin Beck   +11 more
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Degron masking outlines degronons, co-degrading functional modules in the proteome

Communications Biology, 2022
Systematic bioinformatics analysis of cooperative degradation of protein complexes indicates that degrons extensively overlap with protein-protein interaction sites, hiding degrons from ubiquitination machinery and suggesting the existence of co ...
Mainak Guharoy, Tamas Lazar, Mauricio Macossay-Castillo, Peter Tompa   +3 more
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Dual drug targeting to kill colon cancers

Cancer Medicine, 2022
Introduction Colorectal cancer (CRC) is driven by a small set of oncogenic and tumour suppressor mutations. However, different combinations of mutations often lead to poor tumour responses to individual anticancer drugs.
Silvia Paola Corona, Francesca Walker, Janet Weinstock, Guillaume Lessene, Maree Faux, Antony W. Burgess   +5 more
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Structure of the TFIIIC subcomplex τA provides insights into RNA polymerase III pre-initiation complex formation

Nature Communications, 2020
Transcription factor TFIIIC plays roles in Pol III transcription and in chromatin organization. CryoEM structure of the yeast TFIIIC subcomplex τA, a negative stain reconstruction of τA bound to the TFIIIB subunits Brf1 and TBP and accompanying ...
Matthias K. Vorländer, Anna Jungblut, Kai Karius, Florence Baudin, Helga Grötsch, Jan Kosinski, Christoph W. Müller   +6 more
doaj   +1 more source

Variable microtubule architecture in the malaria parasite

Nature Communications, 2023
Microtubules are a ubiquitous eukaryotic cytoskeletal element typically consisting of 13 protofilaments arranged in a hollow cylinder. Using CryoEM and subvolume averaging, Ferreira and Pražák et al.
Josie L. Ferreira, Vojtěch Pražák, Daven Vasishtan, Marc Siggel, Franziska Hentzschel, Annika M. Binder, Emma Pietsch, Jan Kosinski, Friedrich Frischknecht, Tim W. Gilberger, Kay Grünewald   +10 more
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Structural biology

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1999
Protein crystallography has become a major technique for understanding cellular processes. This has come about through great advances in the technology of data collection and interpretation, particularly the use of synchrotron radiation. The ability to express eukaryotic genes in Escherichia coli
openaire   +4 more sources