Results 81 to 90 of about 278,502 (315)

Mechanotransduction mechanisms in human erythrocytes: Fundamental physiology and clinical significance

Channels
The hallmarks of mechanosensitive ion channels have been observed for half a century in various cell lines, although their mechanisms and molecular identities remained unknown until recently. Identification of the bona fide mammalian mechanosensory Piezo
Lennart Kuck, Lars Kaestner, Stéphane Egée, Virgilio L. Lew, Michael J. Simmonds   +4 more
doaj   +1 more source

New face of Journal of Medical Physics and Biophysics: a reflection of new spirit from a new organization [PDF]

, 2017
The meeting in Yogyakarta in November 2015 marked a new chapter of Medical Physics educational, scientific, and professional development in Indonesia; a new professional body, declared as Indonesian Association of Physicists in Medicine, was born a ...
Pawiro, Supriyanto Ardjo; University of Indonesia
core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Erythrocyte Distribution by Surface Charge: Biophysical Characteristics of Heterogeneity, Diagnostic Significance and Application in Transfusionology and Biobanking

Innovative Biosystems and Bioengineering
Long-term storage of erythrocytes, a vital component of modern transfusion medicine, is accompanied by structural, metabolic, and biophysical alterations that reduce their functional activity.
Daniil Liadov, Volodymyr Berest, Tetiana Liadova, Fedir Hladkykh   +3 more
doaj   +1 more source

Proposal to Abolish the Division of Sensory Biophysics

, 2006
This document contains the proposal to abolish the Division of Sensory ...
Ohio State University. College of the Arts and Sciences. Division of Sensory Biophysics
core  

Look Beyond Plasma Membrane Biophysics: Revealing Considerable Variability of the Dipole Potential Between Plasma and Organelle Membranes of Living Cells

Due to the lack of measurement techniques suitable for examining compartments of intact, living cells, membrane biophysics is almost exclusively investigated in the plasma membrane despite the fact that its alterations in intracellular organelles may ...
Florina Zakany, Mate Szabo, Zoltan Varga, Kitti Kurtan, Peter Nagy, Bence Cs. Szabo, Gyorgy Panyi, Tamas Kovacs   +7 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Hackathons for biophysics education: simulating the cytoskeleton

Hackathons are intensive innovation-oriented events where participants work in teams to solve problems or create projects in as little as 24 or 48 hours. These events are common in startup culture, open source communities and mainstream industry. Here we
Zimmer, Patrick, Pollack, Yoav G., Klass, Emily, Mendozza, Raffaele, Bhattacharyya, Komal, Hussin, Anas, Iyer V S, Krishna, Wellecke, Gerrit   +7 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Entropy and Information within Intrinsically Disordered Protein Regions

Entropy, 2019
Bioinformatics and biophysical studies of intrinsically disordered proteins and regions (IDRs) note the high entropy at individual sequence positions and in conformations sampled in solution.
Iva Pritišanac, Robert M. Vernon, Alan M. Moses, Julie D. Forman Kay   +3 more
doaj   +1 more source