Results 1 to 10 of about 1,085 (173)

Enzymatic Reaction Network-Driven Polymerization-Induced Transient Coacervation. [PDF]

Angew Chem Int Ed Engl
An enzymatic reaction network (ERN) for polymerization‐induced transient coacervation (ERN‐PIC), with complete control over the system: polymerization, coacervation, dissolution and selective cargo uptake. Abstract A living cell has a highly complex microenvironment whereas numerous enzyme‐driven processes are active at once.
Sharma S, Belluati A, Kumar M, Dhiman S.
europepmc   +2 more sources

Shaping and coordinating the implementation science agenda for injectable cabotegravir for PrEP: the role of the Biomedical Prevention Implementation Collaborative (BioPIC) [PDF]

Journal of the International AIDS Society, 2023
Introduction Data from two randomized controlled trials (RCTs) showed that injectable cabotegravir (CAB) for pre‐exposure prophylaxis (PrEP) was efficacious in reducing HIV acquisition.
Mitchell Warren, Wawira Nyagah, Catherine Verde Hashim, Michelle Rodolph, Robin Schaefer, Heather‐Marie A Schmidt, Rachel Baggaley   +6 more
doaj   +2 more sources

Changes in DOM Quality Determine Prokaryotic Activities and Extracellular Release in the NW Mediterranean Sea: An Experimental Approach. [PDF]

Environ Microbiol Rep
Changes in DOM composition influence prokaryotic species growth in the Mediterranean Sea, shaping their metabolic responses and organic matter processing. In our study, higher DOP consumption and alkaline phosphatase activity led to the accumulation of recalcitrant DOM, highlighting how microbial community shifts drive distinct pathways in carbon ...
Ortega-Retuerta E, Bouchachi N, Campos R, Crispi O, Marie B, Paulin CH, Escoubeyrou K, Colombet J, Sime-Ngando T, Von Jackowski A.   +9 more
europepmc   +2 more sources

Human umbilical cord mesenchymal stem cells therapy alleviates kidney injury and podocyte apoptosis in Col4a5 knockout male mice. [PDF]

Clin Transl Med
Clinical and Translational Medicine, Volume 15, Issue 10, October 2025.
Lu D, Ye Z, Xu L, Zhou S, Li G, Zhang J, Liu Y, Li Y, Lian Q, Shen Z, Lin J, Wang Q, Gao X.   +12 more
europepmc   +2 more sources

DNA-Protein Binding is Dominated by Short Anchoring Elements. [PDF]

Adv Sci (Weinh)
This study delineate the binding mechanism of transcription factors (TFs) in the genome with the knowledge obtained at thermodynamic equilibrium conditions. Through KaScape experiments, combined with the AEEscape algorithm development, they identified the minimal dominant interacting elements, termed as Anchoring Elements (AEs).
Chen H, Xu Y, Ge H, Su XD.
europepmc   +2 more sources

Macrophage-derived reactive oxygen species promote <i>Salmonella</i> aggresome formation contributing to bacterial antibiotic persistence. [PDF]

Imeta
In this study, we reveal that macrophage‐derived reactive oxygen species (ROS) can trigger the rapid formation of Salmonella aggresomes, which substantially contribute to the increased frequency of persisters induced by phagocytosis. Salmonella containing aggresomes exhibited a dormant phenotype characterized by reduced adenosine triphosphate (ATP ...
Chen X, Fang K, Li B, Li Y, Ke Y, Ke W, Tian T, Zhao Y, Wang L, Geng J, Leake MC, Bai F.   +11 more
europepmc   +2 more sources

Chromatin-intrinsic mechanisms determine orientation-specific class switch recombination [PDF]

Nature Communications
Activation-induced cytidine deaminase (AID)-initiated immunoglobulin heavy chain (Igh) class switch recombination (CSR) replaces donor Cμ constant region exons (CHs) with a downstream acceptor CH to generate different functional antibody isotypes ...
Sha Luo, Ruolin Qiao, Hailiang Zha, Leyi Yu, Xiaoling Shan, Shuchan Li, Zifan Yang, Aoyu Ma, Yaxin Cheng, Yao-Feng Zhao, Xuefei Zhang   +10 more
doaj   +2 more sources

Pleistocene Climate Changes and Lineage Diversification of <i>Sphenarium</i> Grasshoppers (Orthoptera: Pyrgomorphidae). [PDF]

Ecol Evol
We investigate the phylogeographic history and paleodistribution patterns of four closely related grasshopper species of the genus Sphenarium to test the relative impact of Pleistocene climate fluctuations on their diversification. We found that each species responded differently to these fluctuations, but their divergence, distribution, and ...
Sanabria-Urbán S, Torres-Miranda A, Prieto-Torres DA, Oyama K, Del Castillo RC.   +4 more
europepmc   +2 more sources

Foundation models for bioinformatics. [PDF]

Quant Biol
Abstract Transformer‐based foundation models such as ChatGPTs have revolutionized our daily life and affected many fields including bioinformatics. In this perspective, we first discuss about the direct application of textual foundation models on bioinformatics tasks, focusing on how to make the most out of canonical large language models and mitigate ...
Chen Z, Wei L, Gao G.
europepmc   +2 more sources

From Flames to the Ocean: Biomass Burning Aerosols Are Associated With Changes in Prokaryotic Communities in the Mediterranean Sea [PDF]

Environ Microbiol
The addition of wildfire fine ash particles (particle size < 20 μm) in Mediterranean summer seawater can increase prokaryotic growth and alter community composition over time, likely through the release of both inorganic and organic substrates by ash particles and by inducing changes in the composition of phytoplankton populations.
Nault N, Gazeau F, Catala P, Marie B, Llort J, Guieu C, Bressac M, Uher E, Montanes M, Pulido‐Villena E, Santín C, Djaoudi K, Galand P, Ortega‐Retuerta E.   +13 more
europepmc   +2 more sources